diff --git a/subsys/usb/device/class/cdc_acm.c b/subsys/usb/device/class/cdc_acm.c
index f28ae7d4387..0c269bd4b2c 100644
--- a/subsys/usb/device/class/cdc_acm.c
+++ b/subsys/usb/device/class/cdc_acm.c
@@ -96,7 +96,7 @@ struct cdc_acm_dev_data_t {
 #if defined(CONFIG_CDC_ACM_DTE_RATE_CALLBACK_SUPPORT)
 	cdc_dte_rate_callback_t rate_cb;
 #endif
-	struct k_work tx_work;
+	struct k_work_delayable tx_work;
 	/* Tx ready status. Signals when */
 	bool tx_ready;
 	bool rx_ready;				/* Rx ready status */
@@ -218,7 +218,7 @@ static void cdc_acm_write_cb(uint8_t ep, int size, void *priv)
 		return;
 	}
 
-	k_work_submit_to_queue(&USB_WORK_Q, &dev_data->tx_work);
+	k_work_schedule_for_queue(&USB_WORK_Q, &dev_data->tx_work, K_NO_WAIT);
 }
 
 static void tx_work_handler(struct k_work *work)
@@ -477,7 +477,7 @@ static int cdc_acm_init(const struct device *dev)
 		dev, dev_data, dev->config, &cdc_acm_data_devlist);
 
 	k_work_init(&dev_data->cb_work, cdc_acm_irq_callback_work_handler);
-	k_work_init(&dev_data->tx_work, tx_work_handler);
+	k_work_init_delayable(&dev_data->tx_work, tx_work_handler);
 
 	return ret;
 }
@@ -513,7 +513,7 @@ static int cdc_acm_fifo_fill(const struct device *dev,
 		LOG_WRN("Ring buffer full, drop %zd bytes", len - wrote);
 	}
 
-	k_work_submit_to_queue(&USB_WORK_Q, &dev_data->tx_work);
+	k_work_schedule_for_queue(&USB_WORK_Q, &dev_data->tx_work, K_NO_WAIT);
 
 	/* Return written to ringbuf data len */
 	return wrote;
@@ -1016,7 +1016,11 @@ static void cdc_acm_poll_out(const struct device *dev, unsigned char c)
 		}
 	}
 
-	k_work_submit_to_queue(&USB_WORK_Q, &dev_data->tx_work);
+	/* Schedule with minimal timeout to make it possible to send more than
+	 * one byte per USB transfer. The latency increase is negligible while
+	 * the increased throughput and reduced CPU usage is easily observable.
+	 */
+	k_work_schedule_for_queue(&USB_WORK_Q, &dev_data->tx_work, K_MSEC(1));
 }
 
 static const struct uart_driver_api cdc_acm_driver_api = {