diff --git a/scripts/pylib/twister/twisterlib/quarantine.py b/scripts/pylib/twister/twisterlib/quarantine.py
index cb05a920ca6..e4baa52781e 100644
--- a/scripts/pylib/twister/twisterlib/quarantine.py
+++ b/scripts/pylib/twister/twisterlib/quarantine.py
@@ -41,6 +41,10 @@ class QuarantineElement:
     architectures: list[str] = field(default_factory=list)
     simulations: list[str] = field(default_factory=list)
     comment: str = 'NA'
+    re_scenarios: list = field(default_factory=list)
+    re_platforms: list = field(default_factory=list)
+    re_architectures: list = field(default_factory=list)
+    re_simulations: list = field(default_factory=list)
 
     def __post_init__(self):
         # If there is no entry in filters then take all possible values.
@@ -53,6 +57,12 @@ class QuarantineElement:
             self.architectures = []
         if 'all' in self.simulations:
             self.simulations = []
+        # keep precompiled regexp entiries to speed-up matching
+        self.re_scenarios = [re.compile(pat) for pat in self.scenarios]
+        self.re_platforms = [re.compile(pat) for pat in self.platforms]
+        self.re_architectures = [re.compile(pat) for pat in self.architectures]
+        self.re_simulations = [re.compile(pat) for pat in self.simulations]
+
         # However, at least one of the filters ('scenarios', platforms' ...)
         # must be given (there is no sense to put all possible configuration
         # into quarantine)
@@ -101,16 +111,16 @@ class QuarantineData:
         for qelem in self.qlist:
             matched: bool = False
             if (qelem.scenarios
-                    and (matched := _is_element_matched(scenario, qelem.scenarios)) is False):
+                    and (matched := _is_element_matched(scenario, qelem.re_scenarios)) is False):
                 continue
             if (qelem.platforms
-                    and (matched := _is_element_matched(platform, qelem.platforms)) is False):
+                    and (matched := _is_element_matched(platform, qelem.re_platforms)) is False):
                 continue
             if (qelem.architectures
-                    and (matched := _is_element_matched(architecture, qelem.architectures)) is False):
+                    and (matched := _is_element_matched(architecture, qelem.re_architectures)) is False):
                 continue
             if (qelem.simulations
-                    and (matched := _is_element_matched(simulation, qelem.simulations)) is False):
+                    and (matched := _is_element_matched(simulation, qelem.re_simulations)) is False):
                 continue
 
             if matched:
@@ -118,9 +128,9 @@ class QuarantineData:
         return None
 
 
-def _is_element_matched(element: str, list_of_elements: list) -> bool:
+def _is_element_matched(element: str, list_of_elements: list[re.Pattern]) -> bool:
     """Return True if given element is matching to any of elements from the list"""
     for pattern in list_of_elements:
-        if re.fullmatch(pattern, element):
+        if pattern.fullmatch(element):
             return True
     return False
diff --git a/scripts/tests/twister/test_quarantine.py b/scripts/tests/twister/test_quarantine.py
index 8988d7978ca..1e4b7d2f405 100644
--- a/scripts/tests/twister/test_quarantine.py
+++ b/scripts/tests/twister/test_quarantine.py
@@ -104,10 +104,9 @@ def test_quarantinedata_post_init():
 
     quarantine_element = QuarantineElement(
         platforms=['dummy platform'],
-        architectures=[]
+        architectures=[],
+        simulations=['dummy simulation', 'another simulation']
     )
-    quarantine_element.scenarios = []
-    quarantine_element.simulations = ['dummy simulation', 'another simulation']
 
     quarantine_data_qlist = [quarantine_element, quarantine_element_dict]