diff --git a/drivers/i2c/CMakeLists.txt b/drivers/i2c/CMakeLists.txt
index 82b716ac13c..c67805e224b 100644
--- a/drivers/i2c/CMakeLists.txt
+++ b/drivers/i2c/CMakeLists.txt
@@ -26,8 +26,8 @@ zephyr_library_sources_ifdef(CONFIG_I2C_MCUX		i2c_mcux.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_MCUX_FLEXCOMM	i2c_mcux_flexcomm.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_MCUX_LPI2C	i2c_mcux_lpi2c.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_EMUL		i2c_emul.c)
-zephyr_library_sources_ifdef(CONFIG_NRFX_TWI		i2c_nrfx_twi.c)
-zephyr_library_sources_ifdef(CONFIG_NRFX_TWIM		i2c_nrfx_twim.c)
+zephyr_library_sources_ifdef(CONFIG_I2C_NRFX_TWI	i2c_nrfx_twi.c)
+zephyr_library_sources_ifdef(CONFIG_I2C_NRFX_TWIM	i2c_nrfx_twim.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_SAM_TWI		i2c_sam_twi.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_SAM_TWIHS    i2c_sam_twihs.c)
 zephyr_library_sources_ifdef(CONFIG_I2C_SAM_TWIM	i2c_sam4l_twim.c)
diff --git a/drivers/i2c/Kconfig.nrfx b/drivers/i2c/Kconfig.nrfx
index b5888149626..1be1ba5aa1a 100644
--- a/drivers/i2c/Kconfig.nrfx
+++ b/drivers/i2c/Kconfig.nrfx
@@ -13,6 +13,20 @@ menuconfig I2C_NRFX
 
 if I2C_NRFX
 
+config I2C_NRFX_TWI
+	def_bool y
+	depends on DT_HAS_NORDIC_NRF_TWI_ENABLED
+	select NRFX_TWI0 if HAS_HW_NRF_TWI0
+	select NRFX_TWI1 if HAS_HW_NRF_TWI1
+
+config I2C_NRFX_TWIM
+	def_bool y
+	depends on DT_HAS_NORDIC_NRF_TWIM_ENABLED
+	select NRFX_TWIM0 if HAS_HW_NRF_TWIM0
+	select NRFX_TWIM1 if HAS_HW_NRF_TWIM1
+	select NRFX_TWIM2 if HAS_HW_NRF_TWIM2
+	select NRFX_TWIM3 if HAS_HW_NRF_TWIM3
+
 config I2C_NRFX_TRANSFER_TIMEOUT
 	int "Transfer timeout [ms]"
 	default 500
@@ -21,48 +35,4 @@ config I2C_NRFX_TRANSFER_TIMEOUT
 	  0 means that the driver should use the K_FOREVER value,
 	  i.e. it should wait as long as necessary.
 
-config I2C_0_NRF_TWI
-	def_bool HAS_HW_NRF_TWI0
-	select NRFX_TWI0
-	help
-	  Enable nRF TWI Master without EasyDMA on port 0.
-
-config I2C_0_NRF_TWIM
-	def_bool HAS_HW_NRF_TWIM0
-	select NRFX_TWIM0
-	help
-	  Enable nRF TWI Master with EasyDMA on port 0.
-	  This peripheral accepts transfers from RAM only,
-	  if provided buffer is placed in flash, transfer will fail.
-
-config I2C_1_NRF_TWI
-	def_bool HAS_HW_NRF_TWI1
-	select NRFX_TWI1
-	help
-	  Enable nRF TWI Master without EasyDMA on port 1.
-
-config I2C_1_NRF_TWIM
-	def_bool HAS_HW_NRF_TWIM1
-	select NRFX_TWIM1
-	help
-	  Enable nRF TWI Master with EasyDMA on port 1.
-	  This peripheral accepts transfers from RAM only,
-	  if provided buffer is placed in flash, transfer will fail.
-
-config I2C_2_NRF_TWIM
-	def_bool HAS_HW_NRF_TWIM2
-	select NRFX_TWIM2
-	help
-	  Enable nRF TWI Master with EasyDMA on port 2.
-	  This peripheral accepts transfers from RAM only,
-	  if provided buffer is placed in flash, transfer will fail.
-
-config I2C_3_NRF_TWIM
-	def_bool HAS_HW_NRF_TWIM3
-	select NRFX_TWIM3
-	help
-	  Enable nRF TWI Master with EasyDMA on port 3.
-	  This peripheral accepts transfers from RAM only,
-	  if provided buffer is placed in flash, transfer will fail.
-
 endif # I2C_NRFX
diff --git a/drivers/i2c/i2c_nrfx_twi.c b/drivers/i2c/i2c_nrfx_twi.c
index e61ec5b977d..bbb070e7e0c 100644
--- a/drivers/i2c/i2c_nrfx_twi.c
+++ b/drivers/i2c/i2c_nrfx_twi.c
@@ -321,10 +321,10 @@ static int twi_nrfx_pm_action(const struct device *dev,
 		      CONFIG_I2C_INIT_PRIORITY,				       \
 		      &i2c_nrfx_twi_driver_api)
 
-#ifdef CONFIG_I2C_0_NRF_TWI
+#ifdef CONFIG_HAS_HW_NRF_TWI0
 I2C_NRFX_TWI_DEVICE(0);
 #endif
 
-#ifdef CONFIG_I2C_1_NRF_TWI
+#ifdef CONFIG_HAS_HW_NRF_TWI1
 I2C_NRFX_TWI_DEVICE(1);
 #endif
diff --git a/drivers/i2c/i2c_nrfx_twim.c b/drivers/i2c/i2c_nrfx_twim.c
index 5d8c329c92f..a24873fc6f8 100644
--- a/drivers/i2c/i2c_nrfx_twim.c
+++ b/drivers/i2c/i2c_nrfx_twim.c
@@ -436,18 +436,18 @@ static int i2c_nrfx_twim_init(const struct device *dev)
 		      CONFIG_I2C_INIT_PRIORITY,				       \
 		      &i2c_nrfx_twim_driver_api)
 
-#ifdef CONFIG_I2C_0_NRF_TWIM
+#ifdef CONFIG_HAS_HW_NRF_TWIM0
 I2C_NRFX_TWIM_DEVICE(0);
 #endif
 
-#ifdef CONFIG_I2C_1_NRF_TWIM
+#ifdef CONFIG_HAS_HW_NRF_TWIM1
 I2C_NRFX_TWIM_DEVICE(1);
 #endif
 
-#ifdef CONFIG_I2C_2_NRF_TWIM
+#ifdef CONFIG_HAS_HW_NRF_TWIM2
 I2C_NRFX_TWIM_DEVICE(2);
 #endif
 
-#ifdef CONFIG_I2C_3_NRF_TWIM
+#ifdef CONFIG_HAS_HW_NRF_TWIM3
 I2C_NRFX_TWIM_DEVICE(3);
 #endif