diff --git a/modules/trusted-firmware-m/CMakeLists.txt b/modules/trusted-firmware-m/CMakeLists.txt
index 27591549b67..f8cb198d1ab 100644
--- a/modules/trusted-firmware-m/CMakeLists.txt
+++ b/modules/trusted-firmware-m/CMakeLists.txt
@@ -40,9 +40,11 @@ if (CONFIG_BUILD_WITH_TFM)
   endif()
   if (CONFIG_TFM_REGRESSION_S)
     list(APPEND TFM_CMAKE_ARGS -DTEST_S=ON)
+    list(APPEND TFM_CMAKE_ARGS -DTFM_S_REG_TEST:BOOL=ON)
   endif()
   if (CONFIG_TFM_REGRESSION_NS)
     list(APPEND TFM_CMAKE_ARGS -DTEST_NS=ON)
+    list(APPEND TFM_CMAKE_ARGS -DTFM_NS_REG_TEST:BOOL=ON)
   endif()
   if (CONFIG_TFM_BL2)
     list(APPEND TFM_CMAKE_ARGS -DBL2=TRUE)
diff --git a/samples/tfm_integration/tfm_regression_test/CMakeLists.txt b/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
index 5f34b1c0b26..571bf986206 100644
--- a/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
+++ b/samples/tfm_integration/tfm_regression_test/CMakeLists.txt
@@ -11,3 +11,51 @@ find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
 project(tfm_regression_test)
 
 target_sources(app PRIVATE src/main.c)
+
+get_target_property(TFM_BINARY_DIR           tfm TFM_BINARY_DIR)
+get_target_property(TFM_NS_BIN_FILE          tfm TFM_NS_BIN_FILE)
+get_target_property(TFM_NS_HEX_FILE          tfm TFM_NS_HEX_FILE)
+get_target_property(TFM_NS_SIGNED_BIN_FILE   tfm TFM_NS_SIGNED_BIN_FILE)
+
+set(TFM_TEST_REPO_PATH ${ZEPHYR_TRUSTED_FIRMWARE_M_MODULE_DIR}/../tf-m-tests)
+
+set(TFM_TEST_DIR         "${TFM_TEST_REPO_PATH}/tests_reg/test/secure_regression")
+set(TFM_TEST_CONFIG_FILE "${TFM_TEST_REPO_PATH}/tests_reg/test/config/config.cmake")
+
+set_property(TARGET zephyr_property_target
+             APPEND PROPERTY TFM_CMAKE_OPTIONS
+             -DCONFIG_TFM_TEST_DIR=${TFM_TEST_DIR}
+)
+
+set_property(TARGET zephyr_property_target
+             APPEND PROPERTY TFM_CMAKE_OPTIONS
+             -DCONFIG_TFM_TEST_CONFIG_FILE=${TFM_TEST_CONFIG_FILE}
+)
+
+include(ExternalProject)
+
+ExternalProject_Add(tfm_regression_test_app
+    SOURCE_DIR ${TFM_TEST_REPO_PATH}/tests_reg
+    BINARY_DIR ${PROJECT_BINARY_DIR}/tfm_ns
+    CONFIGURE_COMMAND
+        ${CMAKE_COMMAND}
+                -G ${CMAKE_GENERATOR}
+                -S ${TFM_TEST_REPO_PATH}/tests_reg
+                -B ${PROJECT_BINARY_DIR}/tfm_ns
+                -DCONFIG_SPE_PATH=${TFM_BINARY_DIR}/api_ns
+                -DTFM_TOOLCHAIN_FILE=cmake/toolchain_ns_GNUARM.cmake
+                -DQCBOR_PATH${QCBOR_PATH_TYPE}=${CONFIG_TFM_QCBOR_PATH}
+                -DCMAKE_BUILD_TYPE=RelWithDebInfo
+    BUILD_COMMAND ${CMAKE_COMMAND} --build .
+    INSTALL_COMMAND ""
+    BUILD_ALWAYS True
+    USES_TERMINAL_BUILD True
+    WORKING_DIRECTORY ${PROJECT_BINARY_DIR}/tfm_ns
+    DEPENDS tfm
+    BUILD_BYPRODUCTS
+        ${TFM_NS_HEX_FILE}
+        ${TFM_NS_BIN_FILE}
+        ${TFM_NS_SIGNED_BIN_FILE}
+)
+
+add_dependencies(app tfm_regression_test_app)