diff --git a/drivers/serial/CMakeLists.txt b/drivers/serial/CMakeLists.txt
index 33a7d56c793..4128acd0b42 100644
--- a/drivers/serial/CMakeLists.txt
+++ b/drivers/serial/CMakeLists.txt
@@ -17,7 +17,6 @@ zephyr_library_sources_if_kconfig(uart_miv.c)
 zephyr_library_sources_if_kconfig(uart_msp432p4xx.c)
 zephyr_library_sources_ifdef(CONFIG_NRF_UART_PERIPHERAL uart_nrfx_uart.c)
 zephyr_library_sources_ifdef(CONFIG_NRF_UARTE_PERIPHERAL uart_nrfx_uarte.c)
-zephyr_library_sources_if_kconfig(uart_ns16550.c)
 zephyr_library_sources_if_kconfig(uart_nsim.c)
 zephyr_library_sources_if_kconfig(uart_qmsi.c)
 zephyr_library_sources_if_kconfig(uart_sam.c)
@@ -32,6 +31,19 @@ zephyr_library_sources_if_kconfig(uart_rv32m1_lpuart.c)
 
 zephyr_library_sources_ifdef(CONFIG_USERSPACE   uart_handlers.c)
 
+if(CONFIG_UART_NS16550)
+  zephyr_library_sources(uart_ns16550.c)
+  foreach(NUM RANGE 0 3)
+    if (CONFIG_UART_NS16550_PORT_${NUM})
+      configure_file(
+        uart_ns16550_port_x.h
+        ${PROJECT_BINARY_DIR}/include/generated/uart_ns16550_port_${NUM}.h
+        @ONLY
+        )
+    endif()
+  endforeach(NUM)
+endif()
+
 if(CONFIG_UART_NATIVE_POSIX)
   zephyr_library_compile_definitions(NO_POSIX_CHEATS)
   zephyr_library_sources(uart_native_posix.c)
diff --git a/drivers/serial/uart_ns16550.c b/drivers/serial/uart_ns16550.c
index 42ab33f9935..fd52eaf3aa0 100644
--- a/drivers/serial/uart_ns16550.c
+++ b/drivers/serial/uart_ns16550.c
@@ -777,257 +777,17 @@ static const struct uart_driver_api uart_ns16550_driver_api = {
 };
 
 #ifdef CONFIG_UART_NS16550_PORT_0
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_0(struct device *port);
+#include <uart_ns16550_port_0.h>
 #endif
 
-static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_0 = {
-	.sys_clk_freq = DT_UART_NS16550_PORT_0_CLK_FREQ,
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-	.irq_config_func = irq_config_func_0,
-#endif
-
-#ifdef DT_UART_NS16550_PORT_0_PCP
-	.pcp = DT_UART_NS16550_PORT_0_PCP,
-#endif
-
-#if DT_UART_NS16550_PORT_0_PCIE
-	.pcie = true,
-	.pcie_bdf = DT_UART_NS16550_PORT_0_BASE_ADDR,
-	.pcie_id = DT_UART_NS16550_PORT_0_SIZE,
-#endif
-};
-
-static struct uart_ns16550_dev_data_t uart_ns16550_dev_data_0 = {
-	.port = DT_UART_NS16550_PORT_0_BASE_ADDR,
-	.baud_rate = DT_UART_NS16550_PORT_0_BAUD_RATE,
-	.options = CONFIG_UART_NS16550_PORT_0_OPTIONS,
-
-#ifdef DT_UART_NS16550_PORT_0_DLF
-	.dlf = DT_UART_NS16550_PORT_0_DLF,
-#endif
-};
-
-DEVICE_AND_API_INIT(uart_ns16550_0, DT_UART_NS16550_PORT_0_NAME, &uart_ns16550_init,
-		    &uart_ns16550_dev_data_0, &uart_ns16550_dev_cfg_0,
-		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
-		    &uart_ns16550_driver_api);
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_0(struct device *dev)
-{
-	ARG_UNUSED(dev);
-
-	IRQ_CONNECT(DT_UART_NS16550_PORT_0_IRQ,
-		    DT_UART_NS16550_PORT_0_IRQ_PRI,
-		    uart_ns16550_isr, DEVICE_GET(uart_ns16550_0),
-		    DT_UART_NS16550_PORT_0_IRQ_FLAGS);
-
-#ifdef UART_NS16550_PCIE_ENABLED
-	if (DEV_CFG(dev)->pcie) {
-		pcie_irq_enable(DT_UART_NS16550_PORT_0_BASE_ADDR,
-				DT_UART_NS16550_PORT_0_IRQ);
-	} else {
-		irq_enable(DT_UART_NS16550_PORT_0_IRQ);
-	}
-#else
-	irq_enable(DT_UART_NS16550_PORT_0_IRQ);
-#endif
-}
-#endif
-
-#endif /* CONFIG_UART_NS16550_PORT_0 */
-
 #ifdef CONFIG_UART_NS16550_PORT_1
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_1(struct device *port);
+#include <uart_ns16550_port_1.h>
 #endif
 
-static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_1 = {
-	.sys_clk_freq = DT_UART_NS16550_PORT_1_CLK_FREQ,
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-	.irq_config_func = irq_config_func_1,
-#endif
-
-#ifdef DT_UART_NS16550_PORT_1_PCP
-	.pcp = DT_UART_NS16550_PORT_1_PCP,
-#endif
-
-#if DT_UART_NS16550_PORT_1_PCIE
-	.pcie = true,
-	.pcie_bdf = DT_UART_NS16550_PORT_1_BASE_ADDR,
-	.pcie_id = DT_UART_NS16550_PORT_1_SIZE,
-#endif
-};
-
-static struct uart_ns16550_dev_data_t uart_ns16550_dev_data_1 = {
-	.port = DT_UART_NS16550_PORT_1_BASE_ADDR,
-	.baud_rate = DT_UART_NS16550_PORT_1_BAUD_RATE,
-	.options = CONFIG_UART_NS16550_PORT_1_OPTIONS,
-
-#ifdef DT_UART_NS16550_PORT_1_DLF
-	.dlf = DT_UART_NS16550_PORT_1_DLF,
-#endif
-};
-
-DEVICE_AND_API_INIT(uart_ns16550_1, DT_UART_NS16550_PORT_1_NAME, &uart_ns16550_init,
-		    &uart_ns16550_dev_data_1, &uart_ns16550_dev_cfg_1,
-		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
-		    &uart_ns16550_driver_api);
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_1(struct device *dev)
-{
-	ARG_UNUSED(dev);
-
-	IRQ_CONNECT(DT_UART_NS16550_PORT_1_IRQ,
-		    DT_UART_NS16550_PORT_1_IRQ_PRI,
-		    uart_ns16550_isr, DEVICE_GET(uart_ns16550_1),
-		    DT_UART_NS16550_PORT_1_IRQ_FLAGS);
-
-#ifdef UART_NS16550_PCIE_ENABLED
-	if (DEV_CFG(dev)->pcie) {
-		pcie_irq_enable(DT_UART_NS16550_PORT_1_BASE_ADDR,
-				DT_UART_NS16550_PORT_1_IRQ);
-	} else {
-		irq_enable(DT_UART_NS16550_PORT_1_IRQ);
-	}
-#else
-	irq_enable(DT_UART_NS16550_PORT_1_IRQ);
-#endif
-}
-#endif
-
-#endif /* CONFIG_UART_NS16550_PORT_1 */
-
 #ifdef CONFIG_UART_NS16550_PORT_2
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_2(struct device *port);
+#include <uart_ns16550_port_2.h>
 #endif
 
-static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_2 = {
-	.sys_clk_freq = DT_UART_NS16550_PORT_2_CLK_FREQ,
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-	.irq_config_func = irq_config_func_2,
-#endif
-
-#ifdef DT_UART_NS16550_PORT_2_PCP
-	.pcp = DT_UART_NS16550_PORT_2_PCP,
-#endif
-
-#if DT_UART_NS16550_PORT_2_PCIE
-	.pcie = true,
-	.pcie_bdf = DT_UART_NS16550_PORT_2_BASE_ADDR,
-	.pcie_id = DT_UART_NS16550_PORT_2_SIZE,
-#endif
-};
-
-static struct uart_ns16550_dev_data_t uart_ns16550_dev_data_2 = {
-	.port = DT_UART_NS16550_PORT_2_BASE_ADDR,
-	.baud_rate = DT_UART_NS16550_PORT_2_BAUD_RATE,
-	.options = CONFIG_UART_NS16550_PORT_2_OPTIONS,
-
-#ifdef DT_UART_NS16550_PORT_2_DLF
-	.dlf = DT_UART_NS16550_PORT_2_DLF,
-#endif
-};
-
-DEVICE_AND_API_INIT(uart_ns16550_2, DT_UART_NS16550_PORT_2_NAME, &uart_ns16550_init,
-		    &uart_ns16550_dev_data_2, &uart_ns16550_dev_cfg_2,
-		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
-		    &uart_ns16550_driver_api);
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_2(struct device *dev)
-{
-	ARG_UNUSED(dev);
-
-	IRQ_CONNECT(DT_UART_NS16550_PORT_2_IRQ,
-		    DT_UART_NS16550_PORT_2_IRQ_PRI,
-		    uart_ns16550_isr, DEVICE_GET(uart_ns16550_2),
-		    DT_UART_NS16550_PORT_2_IRQ_FLAGS);
-
-#ifdef UART_NS16550_PCIE_ENABLED
-	if (DEV_CFG(dev)->pcie) {
-		pcie_irq_enable(DT_UART_NS16550_PORT_2_BASE_ADDR,
-				DT_UART_NS16550_PORT_2_IRQ);
-	} else {
-		irq_enable(DT_UART_NS16550_PORT_2_IRQ);
-	}
-#else
-	irq_enable(DT_UART_NS16550_PORT_2_IRQ);
-#endif
-}
-#endif
-
-#endif /* CONFIG_UART_NS16550_PORT_2 */
-
 #ifdef CONFIG_UART_NS16550_PORT_3
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_3(struct device *port);
+#include <uart_ns16550_port_3.h>
 #endif
-
-static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_3 = {
-	.sys_clk_freq = DT_UART_NS16550_PORT_3_CLK_FREQ,
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-	.irq_config_func = irq_config_func_3,
-#endif
-
-#ifdef DT_UART_NS16550_PORT_3_PCP
-	.pcp = DT_UART_NS16550_PORT_3_PCP,
-#endif
-
-#if DT_UART_NS16550_PORT_3_PCIE
-	.pcie = true,
-	.pcie_bdf = DT_UART_NS16550_PORT_3_BASE_ADDR,
-	.pcie_id = DT_UART_NS16550_PORT_3_SIZE,
-#endif
-};
-
-static struct uart_ns16550_dev_data_t uart_ns16550_dev_data_3 = {
-	.port = DT_UART_NS16550_PORT_3_BASE_ADDR,
-	.baud_rate = DT_UART_NS16550_PORT_3_BAUD_RATE,
-	.options = CONFIG_UART_NS16550_PORT_3_OPTIONS,
-
-#ifdef DT_UART_NS16550_PORT_3_DLF
-	.dlf = DT_UART_NS16550_PORT_3_DLF,
-#endif
-};
-
-DEVICE_AND_API_INIT(uart_ns16550_3, DT_UART_NS16550_PORT_3_NAME, &uart_ns16550_init,
-		    &uart_ns16550_dev_data_3, &uart_ns16550_dev_cfg_3,
-		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
-		    &uart_ns16550_driver_api);
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void irq_config_func_3(struct device *dev)
-{
-	ARG_UNUSED(dev);
-
-	IRQ_CONNECT(DT_UART_NS16550_PORT_3_IRQ,
-		    DT_UART_NS16550_PORT_3_IRQ_PRI,
-		    uart_ns16550_isr, DEVICE_GET(uart_ns16550_3),
-		    DT_UART_NS16550_PORT_3_IRQ_FLAGS);
-
-#ifdef UART_NS16550_PCIE_ENABLED
-	if (DEV_CFG(dev)->pcie) {
-		pcie_irq_enable(DT_UART_NS16550_PORT_3_BASE_ADDR,
-				DT_UART_NS16550_PORT_3_IRQ);
-	} else {
-		irq_enable(DT_UART_NS16550_PORT_3_IRQ);
-	}
-#else
-	irq_enable(DT_UART_NS16550_PORT_3_IRQ);
-#endif
-}
-#endif
-
-#endif /* CONFIG_UART_NS16550_PORT_3 */
diff --git a/drivers/serial/uart_ns16550_port_x.h b/drivers/serial/uart_ns16550_port_x.h
new file mode 100644
index 00000000000..7a3311feb3d
--- /dev/null
+++ b/drivers/serial/uart_ns16550_port_x.h
@@ -0,0 +1,69 @@
+/*
+ * Copyright (c) 2010, 2012-2015 Wind River Systems, Inc.
+ * Copyright (c) 2019 Intel Corp.
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ *
+ * This file is a template for cmake and is not meant to be used directly!
+ */
+
+#ifdef CONFIG_UART_INTERRUPT_DRIVEN
+static void irq_config_func_@NUM@(struct device *port);
+#endif
+
+static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_@NUM@ = {
+	.sys_clk_freq = DT_UART_NS16550_PORT_@NUM@_CLK_FREQ,
+
+#ifdef CONFIG_UART_INTERRUPT_DRIVEN
+	.irq_config_func = irq_config_func_@NUM@,
+#endif
+
+#ifdef DT_UART_NS16550_PORT_@NUM@_PCP
+	.pcp = DT_UART_NS16550_PORT_@NUM@_PCP,
+#endif
+
+#if DT_UART_NS16550_PORT_@NUM@_PCIE
+	.pcie = true,
+	.pcie_bdf = DT_UART_NS16550_PORT_@NUM@_BASE_ADDR,
+	.pcie_id = DT_UART_NS16550_PORT_@NUM@_SIZE,
+#endif
+};
+
+static struct uart_ns16550_dev_data_t uart_ns16550_dev_data_@NUM@ = {
+	.port = DT_UART_NS16550_PORT_@NUM@_BASE_ADDR,
+	.baud_rate = DT_UART_NS16550_PORT_@NUM@_BAUD_RATE,
+	.options = CONFIG_UART_NS16550_PORT_@NUM@_OPTIONS,
+
+#ifdef DT_UART_NS16550_PORT_@NUM@_DLF
+	.dlf = DT_UART_NS16550_PORT_@NUM@_DLF,
+#endif
+};
+
+DEVICE_AND_API_INIT(uart_ns16550_@NUM@, DT_UART_NS16550_PORT_@NUM@_NAME,
+		    &uart_ns16550_init,
+		    &uart_ns16550_dev_data_@NUM@, &uart_ns16550_dev_cfg_@NUM@,
+		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
+		    &uart_ns16550_driver_api);
+
+#ifdef CONFIG_UART_INTERRUPT_DRIVEN
+static void irq_config_func_@NUM@(struct device *dev)
+{
+	ARG_UNUSED(dev);
+
+	IRQ_CONNECT(DT_UART_NS16550_PORT_@NUM@_IRQ,
+		    DT_UART_NS16550_PORT_@NUM@_IRQ_PRI,
+		    uart_ns16550_isr, DEVICE_GET(uart_ns16550_@NUM@),
+		    DT_UART_NS16550_PORT_@NUM@_IRQ_FLAGS);
+
+#ifdef UART_NS16550_PCIE_ENABLED
+	if (DEV_CFG(dev)->pcie) {
+		pcie_irq_enable(DT_UART_NS16550_PORT_@NUM@_BASE_ADDR,
+				DT_UART_NS16550_PORT_@NUM@_IRQ);
+	} else {
+		irq_enable(DT_UART_NS16550_PORT_@NUM@_IRQ);
+	}
+#else
+	irq_enable(DT_UART_NS16550_PORT_@NUM@_IRQ);
+#endif
+}
+#endif