diff --git a/boards/arm/frdm_k64f/frdm_k64f.dts b/boards/arm/frdm_k64f/frdm_k64f.dts
index 48e284cb2b8..90f4368e9db 100644
--- a/boards/arm/frdm_k64f/frdm_k64f.dts
+++ b/boards/arm/frdm_k64f/frdm_k64f.dts
@@ -241,7 +241,8 @@ zephyr_udc0: &usbotg {
 		     &RMII0_MDC_PTB1>;
 	pinctrl-names = "default";
 	ptp {
-		status = "okay";
+		/* Be aware that PTC16 and PTC17 are also used for uart3 */
+		status = "disabled";
 		pinctrl-0 = <&ENET0_1588_TMR0_PTC16 &ENET0_1588_TMR1_PTC17
 			     &ENET0_1588_TMR2_PTC18>;
 		pinctrl-names = "default";
diff --git a/boards/arm/frdm_k64f/pinmux.c b/boards/arm/frdm_k64f/pinmux.c
index 1636231e422..4a718226f98 100644
--- a/boards/arm/frdm_k64f/pinmux.c
+++ b/boards/arm/frdm_k64f/pinmux.c
@@ -104,10 +104,12 @@ static int frdm_k64f_pinmux_init(const struct device *dev)
 
 	pinmux_pin_set(portb,  1, PORT_PCR_MUX(kPORT_MuxAlt4));
 
+#if DT_NODE_HAS_STATUS(DT_CHILD(DT_NODELABEL(enet),  ptp), okay)
 	pinmux_pin_set(portc, 16, PORT_PCR_MUX(kPORT_MuxAlt4));
 	pinmux_pin_set(portc, 17, PORT_PCR_MUX(kPORT_MuxAlt4));
 	pinmux_pin_set(portc, 18, PORT_PCR_MUX(kPORT_MuxAlt4));
 #endif
+#endif
 
 #if DT_NODE_HAS_STATUS(DT_NODELABEL(flexcan0), okay) && CONFIG_CAN
 	/* FlexCAN0 RX, TX */
diff --git a/samples/net/gptp/boards/frdm_k64f.overlay b/samples/net/gptp/boards/frdm_k64f.overlay
new file mode 100644
index 00000000000..baccbf8f044
--- /dev/null
+++ b/samples/net/gptp/boards/frdm_k64f.overlay
@@ -0,0 +1,12 @@
+/*
+ * Copyright (c) 2021 Esco Medical Aps
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+&enet {
+
+	ptp {
+		status = "ok";
+	};
+};
diff --git a/tests/net/ptp/clock/boards/frdm_k64f.overlay b/tests/net/ptp/clock/boards/frdm_k64f.overlay
new file mode 100644
index 00000000000..baccbf8f044
--- /dev/null
+++ b/tests/net/ptp/clock/boards/frdm_k64f.overlay
@@ -0,0 +1,12 @@
+/*
+ * Copyright (c) 2021 Esco Medical Aps
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+&enet {
+
+	ptp {
+		status = "ok";
+	};
+};