diff --git a/include/bluetooth/uuid.h b/include/bluetooth/uuid.h
index 8bf3ed01cf3..6576f700180 100644
--- a/include/bluetooth/uuid.h
+++ b/include/bluetooth/uuid.h
@@ -79,6 +79,51 @@ struct bt_uuid_128 {
 #define BT_UUID_32(__u) CONTAINER_OF(__u, struct bt_uuid_32, uuid)
 #define BT_UUID_128(__u) CONTAINER_OF(__u, struct bt_uuid_128, uuid)
 
+
+/**
+ * @brief Encode 128 bit UUID into an array values
+ *
+ * Helper macro to initialize a 128-bit UUID value from the UUID format.
+ * Can be combined with BT_UUID_DECLARE_128 to declare a 128-bit UUID from
+ * the readable form of UUIDs.
+ *
+ * Example for how to declare the UUID `6E400001-B5A3-F393-E0A9-E50E24DCCA9E`
+ *
+ * @code
+ * BT_UUID_128_DECL(
+ *       BT_UUID_128_ENC(0x6E400001, 0xB5A3, 0xF393, 0xE0A9, 0xE50E24DCCA9E))
+ * @endcode
+ *
+ * Just replace the hyphen by the comma and add `0x` prefixes.
+ *
+ * @param w32 First part of the UUID (32 bits)
+ * @param w1  Second part of the UUID (16 bits)
+ * @param w2  Third part of the UUID (16 bits)
+ * @param w3  Fourth part of the UUID (16 bits)
+ * @param w48 Fifth part of the UUID (48 bits)
+ *
+ * @return The comma separated values for UUID 128 initializer that
+ *         may be used directly as an argument for
+ *         @ref BT_UUID_INIT_128 or @ref BT_UUID_DECLARE_128
+ */
+#define BT_UUID_128_ENCODE(w32, w1, w2, w3, w48) \
+	(((w48) >>  0) & 0xFF), \
+	(((w48) >>  8) & 0xFF), \
+	(((w48) >> 16) & 0xFF), \
+	(((w48) >> 24) & 0xFF), \
+	(((w48) >> 32) & 0xFF), \
+	(((w48) >> 40) & 0xFF), \
+	(((w3)  >>  0) & 0xFF), \
+	(((w3)  >>  8) & 0xFF), \
+	(((w2)  >>  0) & 0xFF), \
+	(((w2)  >>  8) & 0xFF), \
+	(((w1)  >>  0) & 0xFF), \
+	(((w1)  >>  8) & 0xFF), \
+	(((w32) >>  0) & 0xFF), \
+	(((w32) >>  8) & 0xFF), \
+	(((w32) >> 16) & 0xFF), \
+	(((w32) >> 24) & 0xFF)
+
 /** @def BT_UUID_GAP
  *  @brief Generic Access
  */
diff --git a/subsys/bluetooth/host/uuid.c b/subsys/bluetooth/host/uuid.c
index 10bb1d71f43..30eaccebd8a 100644
--- a/subsys/bluetooth/host/uuid.c
+++ b/subsys/bluetooth/host/uuid.c
@@ -17,19 +17,15 @@
 
 /* TODO: Decide whether to continue using BLE format or switch to RFC 4122 */
 
-/* Base UUID : 0000[0000]-0000-1000-8000-00805F9B34FB ->
- * { 0xfb, 0x34, 0x9b, 0x5f, 0x80, 0x00, 0x00, 0x80,
- *   0x00, 0x10, 0x00, 0x00, [0x00, 0x00], 0x00, 0x00 }
- * 0x2800    : 0000[2800]-0000-1000-8000-00805F9B34FB ->
- * { 0xfb, 0x34, 0x9b, 0x5f, 0x80, 0x00, 0x00, 0x80,
- *   0x00, 0x10, 0x00, 0x00, [0x00, 0x28], 0x00, 0x00 }
+/* Base UUID : 0000[0000]-0000-1000-8000-00805F9B34FB
+ * 0x2800    : 0000[2800]-0000-1000-8000-00805F9B34FB
  *  little endian 0x2800 : [00 28] -> no swapping required
  *  big endian 0x2800    : [28 00] -> swapping required
  */
 static const struct bt_uuid_128 uuid128_base = {
 	.uuid.type = BT_UUID_TYPE_128,
-	.val = { 0xfb, 0x34, 0x9b, 0x5f, 0x80, 0x00, 0x00, 0x80,
-		 0x00, 0x10, 0x00, 0x00, 0x00, 0x00, 0x00, 0x00 },
+	.val = { BT_UUID_128_ENCODE(
+		0x00000000, 0x0000, 0x1000, 0x8000, 0x00805F9B34FB) }
 };
 
 static void uuid_to_uuid128(const struct bt_uuid *src, struct bt_uuid_128 *dst)