diff --git a/samples/drivers/mbox/CMakeLists.txt b/samples/drivers/mbox/CMakeLists.txt
index d94fdffbfb1..e65d44f0048 100644
--- a/samples/drivers/mbox/CMakeLists.txt
+++ b/samples/drivers/mbox/CMakeLists.txt
@@ -6,35 +6,19 @@
 
 cmake_minimum_required(VERSION 3.20.0)
 
-set(REMOTE_ZEPHYR_DIR ${CMAKE_CURRENT_BINARY_DIR}/mbox_ipc_remote-prefix/src/mbox_ipc_remote-build/zephyr)
+find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
 
-if("${BOARD}" STREQUAL "nrf5340dk_nrf5340_cpuapp")
-  set(BOARD_REMOTE "nrf5340dk_nrf5340_cpunet")
-elseif("${BOARD}" STREQUAL "adp_xc7k_ae350")
-  set(BOARD_REMOTE "adp_xc7k_ae350")
-elseif("${BOARD}" STREQUAL "mimxrt595_evk_cm33")
-  set(BOARD_REMOTE "nrf5340dk_nrf5340_cpunet")
+if(("${BOARD}" STREQUAL "nrf5340dk_nrf5340_cpuapp") OR
+   ("${BOARD}" STREQUAL "nrf5340bsim_nrf5340_cpuapp") OR
+   ("${BOARD}" STREQUAL "adp_xc7k_ae350") OR
+   ("${BOARD}" STREQUAL "mimxrt595_evk_cm33"))
+  message(STATUS "${BOARD} compile as Main in this sample")
 else()
   message(FATAL_ERROR "${BOARD} is not supported for this sample")
 endif()
 
-message(STATUS "${BOARD} compile as Main in this sample")
-
-find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
 project(mbox_ipc)
 
 enable_language(C ASM)
 
 target_sources(app PRIVATE src/main.c)
-
-include(ExternalProject)
-
-ExternalProject_Add(
-  mbox_ipc_remote
-  SOURCE_DIR ${APPLICATION_SOURCE_DIR}/remote
-  INSTALL_COMMAND ""      # This particular build system has no install command
-  CMAKE_CACHE_ARGS -DBOARD:STRING=${BOARD_REMOTE}
-  BUILD_BYPRODUCTS "${REMOTE_ZEPHYR_DIR}/${KERNEL_BIN_NAME}"
-  # NB: Do we need to pass on more CMake variables?
-  BUILD_ALWAYS True
-)
diff --git a/samples/drivers/mbox/Kconfig.sysbuild b/samples/drivers/mbox/Kconfig.sysbuild
new file mode 100644
index 00000000000..46ffe3e12ae
--- /dev/null
+++ b/samples/drivers/mbox/Kconfig.sysbuild
@@ -0,0 +1,12 @@
+# Copyright 2023 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: Apache-2.0
+
+source "share/sysbuild/Kconfig"
+
+config REMOTE_BOARD
+string
+	default "nrf5340dk_nrf5340_cpunet" if $(BOARD) = "nrf5340dk_nrf5340_cpuapp"
+	default "nrf5340bsim_nrf5340_cpunet" if $(BOARD) = "nrf5340bsim_nrf5340_cpuapp"
+	default "adp_xc7k_ae350" if $(BOARD) = "adp_xc7k_ae350"
+	default "nrf5340dk_nrf5340_cpunet" if $(BOARD) = "mimxrt595_evk_cm33"
diff --git a/samples/drivers/mbox/README.rst b/samples/drivers/mbox/README.rst
index 35c421335f9..cee903710f7 100644
--- a/samples/drivers/mbox/README.rst
+++ b/samples/drivers/mbox/README.rst
@@ -21,6 +21,7 @@ Building the application for nrf5340dk_nrf5340_cpuapp
    :zephyr-app: samples/drivers/mbox/
    :board: nrf5340dk_nrf5340_cpuapp
    :goals: debug
+   :west-args: --sysbuild
 
 Open a serial terminal (minicom, putty, etc.) and connect the board with the
 following settings:
@@ -58,3 +59,23 @@ core:
    Pong (on channel 1)
    Ping (on channel 0)
    Pong (on channel 1)
+
+
+Building the application for the simulated nrf5340bsim
+******************************************************
+
+.. zephyr-app-commands::
+   :zephyr-app: samples/drivers/mbox/
+   :host-os: unix
+   :board: nrf5340bsim_nrf5340_cpuapp
+   :goals: build
+   :west-args: --sysbuild
+
+Then you can execute your application using:
+
+.. code-block:: console
+
+   $ ./build/zephyr/zephyr.exe -nosim
+   # Press Ctrl+C to exit
+
+You can expect a similar output as in the real HW in the invoking console.
diff --git a/samples/drivers/mbox/remote/CMakeLists.txt b/samples/drivers/mbox/remote/CMakeLists.txt
index a2efccf2227..3aee2d96482 100644
--- a/samples/drivers/mbox/remote/CMakeLists.txt
+++ b/samples/drivers/mbox/remote/CMakeLists.txt
@@ -6,15 +6,16 @@
 
 cmake_minimum_required(VERSION 3.20.0)
 
-if("${BOARD}" STREQUAL "nrf5340dk_nrf5340_cpunet")
-  message(STATUS "${BOARD} compile as remote in this sample")
-elseif("${BOARD}" STREQUAL "adp_xc7k_ae350")
+find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
+
+if(("${BOARD}" STREQUAL "nrf5340dk_nrf5340_cpunet") OR
+  ("${BOARD}" STREQUAL "nrf5340bsim_nrf5340_cpunet") OR
+  ("${BOARD}" STREQUAL "adp_xc7k_ae350"))
   message(STATUS "${BOARD} compile as remote in this sample")
 else()
   message(FATAL_ERROR "${BOARD} is not supported for this sample")
 endif()
 
-find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
 project(mbox_ipc_remote)
 
 target_sources(app PRIVATE src/main.c)
diff --git a/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf b/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
new file mode 100644
index 00000000000..665e456f504
--- /dev/null
+++ b/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
@@ -0,0 +1,2 @@
+CONFIG_MBOX_NRFX_IPC=y
+CONFIG_BUILD_OUTPUT_EXE=n
diff --git a/samples/drivers/mbox/remote/sample.yaml b/samples/drivers/mbox/remote/sample.yaml
deleted file mode 100644
index 014ad53a126..00000000000
--- a/samples/drivers/mbox/remote/sample.yaml
+++ /dev/null
@@ -1,9 +0,0 @@
-sample:
-  name: MBOX IPC sample (remote)
-tests:
-  sample.drivers.mbox_remote:
-    platform_allow: nrf5340dk_nrf5340_cpunet adp_xc7k_ae350
-    integration_platforms:
-      - nrf5340dk_nrf5340_cpunet
-    tags: mbox
-    harness: remote
diff --git a/samples/drivers/mbox/sample.yaml b/samples/drivers/mbox/sample.yaml
index eb5e5ac1a5d..01f894832fc 100644
--- a/samples/drivers/mbox/sample.yaml
+++ b/samples/drivers/mbox/sample.yaml
@@ -1,9 +1,12 @@
 sample:
   name: MBOX IPC sample
 tests:
+  common:
+    sysbuild: true
   sample.drivers.mbox:
     platform_allow:
       - nrf5340dk_nrf5340_cpuapp
+      - nrf5340bsim_nrf5340_cpuapp
       - adp_xc7k_ae350
       - mimxrt595_evk_cm33
     integration_platforms:
diff --git a/samples/drivers/mbox/sysbuild.cmake b/samples/drivers/mbox/sysbuild.cmake
new file mode 100644
index 00000000000..1bd6a00ae9e
--- /dev/null
+++ b/samples/drivers/mbox/sysbuild.cmake
@@ -0,0 +1,38 @@
+# Copyright (c) 2023 Nordic Semiconductor ASA
+# SPDX-License-Identifier: Apache-2.0
+
+if("${SB_CONFIG_REMOTE_BOARD}" STREQUAL "")
+	message(FATAL_ERROR
+	"Target ${BOARD} not supported for this sample. "
+	"There is no remote board selected in Kconfig.sysbuild")
+endif()
+
+set(REMOTE_APP remote)
+
+ExternalZephyrProject_Add(
+	APPLICATION ${REMOTE_APP}
+	SOURCE_DIR  ${APP_DIR}/${REMOTE_APP}
+	BOARD       ${SB_CONFIG_REMOTE_BOARD}
+)
+
+if("${BOARD}" STREQUAL "nrf5340bsim_nrf5340_cpuapp")
+	# For the simulated board, the application core build will produce the final executable
+	# for that, we give it the path to the netcore image
+	set(NET_LIBRARY_PATH ${CMAKE_BINARY_DIR}/${REMOTE_APP}/zephyr/zephyr.elf)
+	set_property(TARGET ${DEFAULT_IMAGE} APPEND_STRING PROPERTY CONFIG
+		"CONFIG_NATIVE_SIMULATOR_EXTRA_IMAGE_PATHS=\"${NET_LIBRARY_PATH}\"\n"
+	)
+
+	# Let's build the net core library first
+	add_dependencies(${DEFAULT_IMAGE} ${REMOTE_APP})
+
+	# Let's meet users expectations of finding the final executable in zephyr/zephyr.exe
+	add_custom_target(final_executable
+		ALL
+		COMMAND
+		${CMAKE_COMMAND} -E copy
+			${CMAKE_BINARY_DIR}/${DEFAULT_IMAGE}/zephyr/zephyr.exe
+			${CMAKE_BINARY_DIR}/zephyr/zephyr.exe
+		DEPENDS ${DEFAULT_IMAGE}
+	)
+endif()