diff --git a/dts/arm/st/f3/stm32f303Xe.dtsi b/dts/arm/st/f3/stm32f303Xe.dtsi
index bb04ee099ae..b997e0fb4ff 100644
--- a/dts/arm/st/f3/stm32f303Xe.dtsi
+++ b/dts/arm/st/f3/stm32f303Xe.dtsi
@@ -41,5 +41,21 @@
 				status = "disabled";
 			};
 		};
+
+		i2c3: i2c@4007800 {
+			compatible = "st,stm32-i2c-v2";
+			clock-frequency = <I2C_BITRATE_STANDARD>;
+			#address-cells = <1>;
+			#size-cells = <0>;
+			reg = <0x40007800 0x400>;
+			clocks = <&rcc STM32_CLOCK(APB1, 30)>,
+				 /* I2C clock source should always be defined,
+				  * even for the default value
+				  */
+				 <&rcc STM32_SRC_SYSCLK I2C3_SEL(1)>;
+			interrupts = <72 0>, <73 0>;
+			interrupt-names = "event", "error";
+			status = "disabled";
+		};
 	};
 };