diff --git a/drivers/serial/uart_async_to_irq.c b/drivers/serial/uart_async_to_irq.c
index f1825eb398e..897ff50fcb5 100644
--- a/drivers/serial/uart_async_to_irq.c
+++ b/drivers/serial/uart_async_to_irq.c
@@ -336,15 +336,8 @@ void z_uart_async_to_irq_irq_callback_set(const struct device *dev,
 int uart_async_to_irq_rx_enable(const struct device *dev)
 {
 	struct uart_async_to_irq_data *data = get_data(dev);
-	const struct uart_async_to_irq_config *config = get_config(dev);
 	int err;
 
-	err = config->api->callback_set(dev, uart_async_to_irq_callback, data);
-	if (err < 0) {
-		return err;
-	}
-
-
 	err = try_rx_enable(dev, data);
 	if (err == 0) {
 		atomic_or(&data->flags, A2I_RX_ENABLE);
@@ -381,13 +374,21 @@ void uart_async_to_irq_trampoline_cb(const struct device *dev)
 	} while (atomic_dec(&data->irq_req) > 1);
 }
 
-int uart_async_to_irq_init(struct uart_async_to_irq_data *data,
-			   const struct uart_async_to_irq_config *config)
+int uart_async_to_irq_init(const struct device *dev)
 {
+	struct uart_async_to_irq_data *data = get_data(dev);
+	const struct uart_async_to_irq_config *config = get_config(dev);
+	int err;
+
 	data->tx.buf = config->tx_buf;
 	data->tx.len = config->tx_len;
 
 	k_sem_init(&data->rx.sem, 0, 1);
 
+	err = config->api->callback_set(dev, uart_async_to_irq_callback, data);
+	if (err < 0) {
+		return err;
+	}
+
 	return uart_async_rx_init(&data->rx.async_rx, &config->async_rx);
 }
diff --git a/drivers/serial/uart_nrfx_uarte2.c b/drivers/serial/uart_nrfx_uarte2.c
index 86a81e92bdb..594f5a79b55 100644
--- a/drivers/serial/uart_nrfx_uarte2.c
+++ b/drivers/serial/uart_nrfx_uarte2.c
@@ -857,7 +857,7 @@ static int uarte_nrfx_init(const struct device *dev)
 
 	if (UARTE_ANY_INTERRUPT_DRIVEN) {
 		if (cfg->a2i_config) {
-			err = uart_async_to_irq_init(data->a2i_data, cfg->a2i_config);
+			err = uart_async_to_irq_init(dev);
 			if (err < 0) {
 				return err;
 			}
diff --git a/include/zephyr/drivers/serial/uart_async_to_irq.h b/include/zephyr/drivers/serial/uart_async_to_irq.h
index d8d2774b174..3b80c9061b5 100644
--- a/include/zephyr/drivers/serial/uart_async_to_irq.h
+++ b/include/zephyr/drivers/serial/uart_async_to_irq.h
@@ -109,13 +109,11 @@ void uart_async_to_irq_trampoline_cb(const struct device *dev);
 
 /** @brief Initialize the adaptation layer.
  *
- * @param data Data associated with the given adaptation layer instance.
- * @param config Configuration structure. Must be persistent.
+ * @param dev UART device. Device must support asynchronous API.
  *
  * @retval 0 On successful initialization.
  */
-int uart_async_to_irq_init(struct uart_async_to_irq_data *data,
-			   const struct uart_async_to_irq_config *config);
+int uart_async_to_irq_init(const struct device *dev);
 
 /* @brief Enable RX for interrupt driven API.
  *