diff --git a/arch/arm/soc/st_stm32/stm32l4/soc.h b/arch/arm/soc/st_stm32/stm32l4/soc.h
index eaeb4103c8a..2397331bb32 100644
--- a/arch/arm/soc/st_stm32/stm32l4/soc.h
+++ b/arch/arm/soc/st_stm32/stm32l4/soc.h
@@ -55,6 +55,11 @@
 #include <stm32l4xx_ll_rng.h>
 #endif
 
+#ifdef CONFIG_USB
+/* Required to remove USB transceiver supply isolation */
+#include <stm32l4xx_ll_pwr.h>
+#endif /* CONFIG_USB */
+
 #endif /* !_ASMLANGUAGE */
 
 #endif /* _STM32L4X_SOC_H_ */
diff --git a/drivers/usb/device/usb_dc_stm32.c b/drivers/usb/device/usb_dc_stm32.c
index c545997ea2b..0c23569fca5 100644
--- a/drivers/usb/device/usb_dc_stm32.c
+++ b/drivers/usb/device/usb_dc_stm32.c
@@ -330,6 +330,21 @@ int usb_dc_attach(void)
 		return ret;
 	}
 
+	/*
+	 * Required for at least STM32L4 devices as they electrically
+	 * isolate USB features from VDDUSB. It must be enabled before
+	 * USB can function. Refer to DM00310109, section 5.1.3.
+	 */
+#ifdef PWR_CR2_PVME1
+	if (LL_APB1_GRP1_IsEnabledClock(LL_APB1_GRP1_PERIPH_PWR)) {
+		LL_PWR_EnableVddUSB();
+	} else {
+		LL_APB1_GRP1_EnableClock(LL_APB1_GRP1_PERIPH_PWR);
+		LL_PWR_EnableVddUSB();
+		LL_APB1_GRP1_DisableClock(LL_APB1_GRP1_PERIPH_PWR);
+	}
+#endif /* PWR_CR2_PVME1 */
+
 	return 0;
 }