diff --git a/boards/arm/lpcxpresso54114/Kconfig.defconfig b/boards/arm/lpcxpresso54114/Kconfig.defconfig
index 95ea74da2b6..63c66e52b71 100644
--- a/boards/arm/lpcxpresso54114/Kconfig.defconfig
+++ b/boards/arm/lpcxpresso54114/Kconfig.defconfig
@@ -9,10 +9,6 @@ config BOARD
 	default "lpcxpresso54114_m4" if BOARD_LPCXPRESSO54114_M4
 	default "lpcxpresso54114_m0" if BOARD_LPCXPRESSO54114_M0
 
-config UART_MCUX_FLEXCOMM_0
-	default y if UART_CONSOLE
-	depends on UART_MCUX_FLEXCOMM
-
 if PINMUX_MCUX_LPC
 
 config PINMUX_MCUX_LPC_PORT0
diff --git a/boards/arm/lpcxpresso55s69/Kconfig.defconfig b/boards/arm/lpcxpresso55s69/Kconfig.defconfig
index 7f5f54b5e8e..e32a1b69ca3 100644
--- a/boards/arm/lpcxpresso55s69/Kconfig.defconfig
+++ b/boards/arm/lpcxpresso55s69/Kconfig.defconfig
@@ -9,10 +9,6 @@ config BOARD
 	default "lpcxpresso55S69_cpu0" if BOARD_LPCXPRESSO55S69_CPU0
 	default "lpcxpresso55S69_cpu1" if BOARD_LPCXPRESSO55S69_CPU1
 
-config UART_MCUX_FLEXCOMM_0
-	default y if UART_CONSOLE
-	depends on UART_MCUX_FLEXCOMM
-
 if PINMUX_MCUX_LPC
 
 config PINMUX_MCUX_LPC_PORT0
diff --git a/drivers/serial/Kconfig.mcux_flexcomm b/drivers/serial/Kconfig.mcux_flexcomm
index 438f60ca160..635ac489b41 100644
--- a/drivers/serial/Kconfig.mcux_flexcomm
+++ b/drivers/serial/Kconfig.mcux_flexcomm
@@ -3,16 +3,10 @@
 # Copyright 2017, NXP
 # SPDX-License-Identifier: Apache-2.0
 
-menuconfig UART_MCUX_FLEXCOMM
+config UART_MCUX_FLEXCOMM
 	bool "MCUX FLEXCOMM UART driver"
 	depends on HAS_MCUX_FLEXCOMM
 	select SERIAL_HAS_DRIVER
 	select SERIAL_SUPPORT_INTERRUPT
 	help
 	  Enable the MCUX USART driver.
-
-config UART_MCUX_FLEXCOMM_0
-	bool "USART 0"
-	depends on UART_MCUX_FLEXCOMM
-	help
-	  Enable USART 0.
diff --git a/drivers/serial/uart_mcux_flexcomm.c b/drivers/serial/uart_mcux_flexcomm.c
index 034bdc8707e..50ca9eb8827 100644
--- a/drivers/serial/uart_mcux_flexcomm.c
+++ b/drivers/serial/uart_mcux_flexcomm.c
@@ -4,6 +4,8 @@
  * SPDX-License-Identifier: Apache-2.0
  */
 
+#define DT_DRV_COMPAT nxp_lpc_usart
+
 /** @file
  * @brief USART driver for LPC54XXX and LPC55xxx families.
  *
@@ -284,37 +286,53 @@ static const struct uart_driver_api mcux_flexcomm_driver_api = {
 #endif
 };
 
-#ifdef CONFIG_UART_MCUX_FLEXCOMM_0
+
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void mcux_flexcomm_config_func_0(struct device *dev);
+#define UART_MCUX_FLEXCOMM_CONFIG_FUNC(n)				\
+	static void mcux_flexcomm_config_func_##n(struct device *dev)	\
+	{								\
+		IRQ_CONNECT(DT_INST_IRQN(n),				\
+			    DT_INST_IRQ(n, priority),			\
+			    mcux_flexcomm_isr, DEVICE_GET(uart_##n), 0);\
+									\
+		irq_enable(DT_INST_IRQN(n));				\
+	}
+#define UART_MCUX_FLEXCOMM_IRQ_CFG_FUNC_INIT(n)				\
+	.irq_config_func = mcux_flexcomm_config_func_##n
+#define UART_MCUX_FLEXCOMM_INIT_CFG(n)					\
+	UART_MCUX_FLEXCOMM_DECLARE_CFG(n,				\
+				       UART_MCUX_FLEXCOMM_IRQ_CFG_FUNC_INIT(n))
+#else
+#define UART_MCUX_FLEXCOMM_CONFIG_FUNC(n)
+#define UART_MCUX_FLEXCOMM_IRQ_CFG_FUNC_INIT
+#define UART_MCUX_FLEXCOMM_INIT_CFG(n)					\
+	UART_MCUX_FLEXCOMM_DECLARE_CFG(n, UART_MCUX_FLEXCOMM_IRQ_CFG_FUNC_INIT)
 #endif
 
-static const struct mcux_flexcomm_config mcux_flexcomm_0_config = {
-	.base = (USART_Type *)DT_NXP_LPC_USART_USART_0_BASE_ADDRESS,
-	.clock_source = 0,
-	.baud_rate = DT_NXP_LPC_USART_USART_0_CURRENT_SPEED,
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-	.irq_config_func = mcux_flexcomm_config_func_0,
-#endif
-};
-
-static struct mcux_flexcomm_data mcux_flexcomm_0_data;
-
-DEVICE_AND_API_INIT(usart_0, DT_NXP_LPC_USART_USART_0_LABEL,
-		    &mcux_flexcomm_init,
-		    &mcux_flexcomm_0_data, &mcux_flexcomm_0_config,
-		    PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,
-		    &mcux_flexcomm_driver_api);
-
-#ifdef CONFIG_UART_INTERRUPT_DRIVEN
-static void mcux_flexcomm_config_func_0(struct device *dev)
-{
-	IRQ_CONNECT(DT_NXP_LPC_USART_USART_0_IRQ_0,
-		    DT_NXP_LPC_USART_USART_0_IRQ_0_PRIORITY,
-		    mcux_flexcomm_isr, DEVICE_GET(usart_0), 0);
-
-	irq_enable(DT_NXP_LPC_USART_USART_0_IRQ_0);
+#define UART_MCUX_FLEXCOMM_DECLARE_CFG(n, IRQ_FUNC_INIT)		\
+static const struct mcux_flexcomm_config mcux_flexcomm_##n##_config = {	\
+	.base = (USART_Type *)DT_INST_REG_ADDR(n),			\
+	.clock_source = 0,						\
+	.baud_rate = DT_INST_PROP(n, current_speed),			\
+	IRQ_FUNC_INIT							\
 }
-#endif
 
-#endif /* CONFIG_UART_MCUX_FLEXCOMM_0 */
+#define UART_MCUX_FLEXCOMM_INIT(n)					\
+									\
+	static struct mcux_flexcomm_data mcux_flexcomm_##n##_data;	\
+									\
+	static const struct mcux_flexcomm_config mcux_flexcomm_##n##_config;\
+									\
+	DEVICE_AND_API_INIT(uart_##n, DT_INST_LABEL(n),			\
+			    &mcux_flexcomm_init,			\
+			    &mcux_flexcomm_##n##_data,			\
+			    &mcux_flexcomm_##n##_config,		\
+			    PRE_KERNEL_1,				\
+			    CONFIG_KERNEL_INIT_PRIORITY_DEVICE,		\
+			    &mcux_flexcomm_driver_api);			\
+									\
+	UART_MCUX_FLEXCOMM_CONFIG_FUNC(n)				\
+									\
+	UART_MCUX_FLEXCOMM_INIT_CFG(n)
+
+DT_INST_FOREACH(UART_MCUX_FLEXCOMM_INIT)