diff --git a/drivers/ieee802154/ieee802154_nrf5.c b/drivers/ieee802154/ieee802154_nrf5.c
index 1b54d76270e..b93daa475a4 100644
--- a/drivers/ieee802154/ieee802154_nrf5.c
+++ b/drivers/ieee802154/ieee802154_nrf5.c
@@ -855,6 +855,27 @@ static int nrf5_configure(const struct device *dev,
 		break;
 #endif /* CONFIG_IEEE802154_CSL_ENDPOINT */
 
+	case IEEE802154_CONFIG_ENH_ACK_HEADER_IE: {
+		uint8_t short_addr_le[SHORT_ADDRESS_SIZE];
+		uint8_t ext_addr_le[EXTENDED_ADDRESS_SIZE];
+
+		/* We expect that addresses are in big endian format, but radio driver requires
+		 * to have them in little endian. Convert addresses to little endian.
+		 */
+		sys_put_le16(config->ack_ie.short_addr, short_addr_le);
+		sys_memcpy_swap(ext_addr_le, config->ack_ie.ext_addr, EXTENDED_ADDRESS_SIZE);
+
+		if (config->ack_ie.data_len > 0) {
+			nrf_802154_ack_data_set(short_addr_le, false, config->ack_ie.data,
+						config->ack_ie.data_len, NRF_802154_ACK_DATA_IE);
+			nrf_802154_ack_data_set(ext_addr_le, true, config->ack_ie.data,
+						config->ack_ie.data_len, NRF_802154_ACK_DATA_IE);
+		} else {
+			nrf_802154_ack_data_clear(short_addr_le, false, NRF_802154_ACK_DATA_IE);
+			nrf_802154_ack_data_clear(ext_addr_le, true, NRF_802154_ACK_DATA_IE);
+		}
+	} break;
+
 	default:
 		return -EINVAL;
 	}