diff --git a/tests/drivers/uart/uart_async_api/boards/nucleo_f746zg_nocachemem.overlay b/tests/drivers/uart/uart_async_api/boards/nucleo_f746zg_nocachemem.overlay
new file mode 100644
index 00000000000..2657a0bf45f
--- /dev/null
+++ b/tests/drivers/uart/uart_async_api/boards/nucleo_f746zg_nocachemem.overlay
@@ -0,0 +1,17 @@
+/*
+ * Copyright (c) 2024 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <zephyr/dt-bindings/memory-attr/memory-attr-arm.h>
+
+/ {
+	/* The async_api.nocache_mem_dt test case expects a non-cachable RAM region */
+	sram_nocache: memory@2004c000 {
+		compatible = "zephyr,memory-region", "mmio-sram";
+		reg = <0x2004c000 DT_SIZE_K(16)>;
+		zephyr,memory-region = "RAM_NOCACHE";
+		zephyr,memory-attr = <DT_MEM_ARM_MPU_RAM_NOCACHE>;
+	};
+};
diff --git a/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg.overlay b/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg.overlay
index 1eef7ad3ae9..9ecaf11a081 100644
--- a/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg.overlay
@@ -1,11 +1,18 @@
 /*
+ * Copyright (c) 2024 STMicroelectronics
+ *
  * SPDX-License-Identifier: Apache-2.0
  */
 
-dut: &usart2 {
-	dmas = <&dmamux1 2 44 STM32_DMA_PERIPH_TX>,
-		<&dmamux1 3 43 STM32_DMA_PERIPH_RX>;
+/* Arduino Header pins: Tx:D9, Rx:D10 */
+dut: &uart9 {
+	pinctrl-0 = <&uart9_tx_pd15 &uart9_rx_pd14>;
+	pinctrl-names = "default";
+	current-speed = <115200>;
+	dmas = <&dmamux1 2 117 STM32_DMA_PERIPH_TX>,
+		<&dmamux1 3 116 STM32_DMA_PERIPH_RX>;
 	dma-names = "tx", "rx";
+	status = "okay";
 };
 
 &dma1 {
diff --git a/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg_nocachemem.overlay b/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg_nocachemem.overlay
new file mode 100644
index 00000000000..fc9393dcf42
--- /dev/null
+++ b/tests/drivers/uart/uart_async_api/boards/nucleo_h723zg_nocachemem.overlay
@@ -0,0 +1,12 @@
+/*
+ * Copyright (c) 2024 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <zephyr/dt-bindings/memory-attr/memory-attr-arm.h>
+
+&sram1 {
+	zephyr,memory-attr = <DT_MEM_ARM_MPU_RAM_NOCACHE>;
+	zephyr,memory-region = "RAM_NOCACHE";
+};
diff --git a/tests/drivers/uart/uart_async_api/stm32_nocache_mem_dt.conf b/tests/drivers/uart/uart_async_api/stm32_nocache_mem_dt.conf
new file mode 100644
index 00000000000..1d24d39f824
--- /dev/null
+++ b/tests/drivers/uart/uart_async_api/stm32_nocache_mem_dt.conf
@@ -0,0 +1,4 @@
+CONFIG_DCACHE=y
+CONFIG_DT_DEFINED_NOCACHE=y
+CONFIG_DT_DEFINED_NOCACHE_NAME="RAM_NOCACHE"
+CONFIG_USERSPACE=n
diff --git a/tests/drivers/uart/uart_async_api/testcase.yaml b/tests/drivers/uart/uart_async_api/testcase.yaml
index a3665f7c570..e7a970d4a58 100644
--- a/tests/drivers/uart/uart_async_api/testcase.yaml
+++ b/tests/drivers/uart/uart_async_api/testcase.yaml
@@ -74,3 +74,39 @@ tests:
       - CONFIG_UART_SAM0_ASYNC=y
       - CONFIG_DMA=y
     build_only: true
+  drivers.uart.async_api.nocache_mem:
+    # nocache memory region is defined by the linker
+    filter: CONFIG_SERIAL_SUPPORT_ASYNC and CONFIG_CPU_HAS_DCACHE
+    harness: ztest
+    harness_config:
+      fixture: gpio_loopback
+    depends_on: gpio
+    platform_allow:
+      - nucleo_f746zg
+      - nucleo_h723zg
+    extra_configs:
+      - CONFIG_DCACHE=y
+      - CONFIG_NOCACHE_MEMORY=y
+      - CONFIG_USERSPACE=n
+  drivers.uart.async_api.nocache_mem_dt.nucleo_f746zg:
+    # nocache memory region is defined in DT
+    harness: ztest
+    harness_config:
+      fixture: gpio_loopback
+    depends_on: gpio
+    platform_allow:
+      - nucleo_f746zg
+    extra_args:
+      - DTC_OVERLAY_FILE="boards/nucleo_f746zg.overlay;boards/nucleo_f746zg_nocachemem.overlay"
+      - EXTRA_CONF_FILE=stm32_nocache_mem_dt.conf
+  drivers.uart.async_api.nocache_mem_dt.nucleo_h723zg:
+    # nocache memory region is defined in DT
+    harness: ztest
+    harness_config:
+      fixture: gpio_loopback
+    depends_on: gpio
+    platform_allow:
+      - nucleo_h723zg
+    extra_args:
+      - DTC_OVERLAY_FILE="boards/nucleo_h723zg.overlay;boards/nucleo_h723zg_nocachemem.overlay"
+      - EXTRA_CONF_FILE=stm32_nocache_mem_dt.conf