diff --git a/boards/arm/thingy53_nrf5340/Kconfig b/boards/arm/thingy53_nrf5340/Kconfig
index 1c2f80a67f0..74b496e2dc3 100644
--- a/boards/arm/thingy53_nrf5340/Kconfig
+++ b/boards/arm/thingy53_nrf5340/Kconfig
@@ -3,13 +3,6 @@
 # Copyright (c) 2021 Nordic Semiconductor ASA
 # SPDX-License-Identifier: Apache-2.0
 
-config THINGY53_MISO_WORKAROUND
-	bool "MISO workaround"
-	default SPI
-	help
-	  Workaround SPI bus MISO issues. The workaround sets dedicated pin
-	  high in order to avoid voltage drops on the SPI MISO line.
-
 config THINGY53_INIT_PRIORITY
 	int "Init priority"
 	default 79
diff --git a/boards/arm/thingy53_nrf5340/board.c b/boards/arm/thingy53_nrf5340/board.c
index fd154e6d681..9e1b62b9767 100644
--- a/boards/arm/thingy53_nrf5340/board.c
+++ b/boards/arm/thingy53_nrf5340/board.c
@@ -13,11 +13,6 @@
 #include <logging/log.h>
 LOG_MODULE_REGISTER(thingy53_board_init);
 
-#define NRF21540FEM_CTRL_NODE		DT_NODELABEL(nrf21540fem_ctrl)
-#define NRF21540FEM_CTRL_PDN_GPIO_NODE	DT_GPIO_CTLR(NRF21540FEM_CTRL_NODE, pdn_gpios)
-#define NRF21540FEM_CTRL_PDN_PIN	DT_GPIO_PIN(NRF21540FEM_CTRL_NODE, pdn_gpios)
-#define NRF21540FEM_CTRL_PDN_FLAGS	DT_GPIO_FLAGS(NRF21540FEM_CTRL_NODE, pdn_gpios)
-
 #define ADXL362_NODE			DT_NODELABEL(adxl362)
 #define ADXL362_GPIO_NODE		DT_SPI_DEV_CS_GPIOS_CTLR(ADXL362_NODE)
 #define ADXL362_CS			DT_SPI_DEV_CS_GPIOS_PIN(ADXL362_NODE)
@@ -28,11 +23,6 @@ LOG_MODULE_REGISTER(thingy53_board_init);
 #define BMI270_CS			DT_SPI_DEV_CS_GPIOS_PIN(BMI270_NODE)
 #define BMI270_FLAGS			DT_SPI_DEV_CS_GPIOS_FLAGS(BMI270_NODE)
 
-#define NRF21540FEM_NODE		DT_NODELABEL(nrf21540fem)
-#define NRF21540FEM_GPIO_NODE		DT_SPI_DEV_CS_GPIOS_CTLR(NRF21540FEM_NODE)
-#define NRF21540FEM_CS			DT_SPI_DEV_CS_GPIOS_PIN(NRF21540FEM_NODE)
-#define NRF21540FEM_FLAGS		DT_SPI_DEV_CS_GPIOS_FLAGS(NRF21540FEM_NODE)
-
 /* Initialization chain of Thingy:53 board requires some delays before on board sensors
  * could be accessed after power up. In particular bme680 and bmm150 sensors require,
  * respectively 2ms and 1ms power on delay. In order to avoid delays sum, common delay is
@@ -56,16 +46,6 @@ BUILD_ASSERT(CONFIG_THINGY53_INIT_PRIORITY < CONFIG_SENSOR_INIT_PRIORITY,
 static void enable_cpunet(void)
 {
 #if !defined(CONFIG_TRUSTED_EXECUTION_NONSECURE)
-	/* Give nRF21540fem control pins to NetworkMCU */
-	nrf_gpio_pin_mcu_select(NRF_DT_GPIOS_TO_PSEL(NRF21540FEM_CTRL_NODE, tx_en_gpios),
-				GPIO_PIN_CNF_MCUSEL_NetworkMCU); /* TX_EN */
-	nrf_gpio_pin_mcu_select(NRF_DT_GPIOS_TO_PSEL(NRF21540FEM_CTRL_NODE, pdn_gpios),
-				GPIO_PIN_CNF_MCUSEL_NetworkMCU); /* PDN */
-	nrf_gpio_pin_mcu_select(NRF_DT_GPIOS_TO_PSEL(NRF21540FEM_CTRL_NODE, rx_en_gpios),
-				GPIO_PIN_CNF_MCUSEL_NetworkMCU); /* RX_EN */
-	nrf_gpio_pin_mcu_select(NRF_DT_GPIOS_TO_PSEL(NRF21540FEM_CTRL_NODE, mode_gpios),
-				GPIO_PIN_CNF_MCUSEL_NetworkMCU); /* MODE */
-
 	/* Retain nRF5340 Network MCU in Secure domain (bus
 	 * accesses by Network MCU will have Secure attribute set).
 	 */
@@ -95,20 +75,6 @@ static int setup(const struct device *dev)
 	const struct device *gpio;
 	int err;
 
-	gpio = DEVICE_DT_GET(NRF21540FEM_CTRL_PDN_GPIO_NODE);
-	if (!device_is_ready(gpio)) {
-		LOG_ERR("%s device not ready", gpio->name);
-		return -ENODEV;
-	}
-	err = gpio_pin_configure(gpio, NRF21540FEM_CTRL_PDN_PIN,
-				 NRF21540FEM_CTRL_PDN_FLAGS |
-				 IS_ENABLED(CONFIG_THINGY53_MISO_WORKAROUND) ?
-				 GPIO_OUTPUT_ACTIVE : GPIO_OUTPUT_INACTIVE);
-	if (err < 0) {
-		LOG_ERR("Failed to configure NRF21540FEM PDN Pin");
-		return err;
-	}
-
 	gpio = DEVICE_DT_GET(ADXL362_GPIO_NODE);
 	if (!device_is_ready(gpio)) {
 		LOG_ERR("%s device not ready", gpio->name);
@@ -131,17 +97,6 @@ static int setup(const struct device *dev)
 		return err;
 	}
 
-	gpio = DEVICE_DT_GET(NRF21540FEM_GPIO_NODE);
-	if (!device_is_ready(gpio)) {
-		LOG_ERR("%s device not ready", gpio->name);
-		return -ENODEV;
-	}
-	err = gpio_pin_configure(gpio, NRF21540FEM_CS, NRF21540FEM_FLAGS | GPIO_OUTPUT_INACTIVE);
-	if (err < 0) {
-		LOG_ERR("Failed to configure NRF21540FEM CS Pin");
-		return err;
-	}
-
 	if (IS_ENABLED(CONFIG_SENSOR)) {
 		/* Initialization chain of Thingy:53 board requires some delays before on board
 		 * sensors could be accessed after power up. In particular bme680 and bmm150
diff --git a/boards/arm/thingy53_nrf5340/thingy53_nrf5340_common.dts b/boards/arm/thingy53_nrf5340/thingy53_nrf5340_common.dts
index 5eb417d0d76..7409631e079 100644
--- a/boards/arm/thingy53_nrf5340/thingy53_nrf5340_common.dts
+++ b/boards/arm/thingy53_nrf5340/thingy53_nrf5340_common.dts
@@ -83,12 +83,13 @@
 		regulator-boot-on;
 	};
 
-	nrf21540fem_ctrl: nrf21540fem-ctrl {
+	nrf_radio_fem: fem {
 		compatible = "nordic,nrf21540-fem";
 		rx-en-gpios = <&gpio1 11 GPIO_ACTIVE_HIGH>;
 		mode-gpios  = <&gpio1 12 GPIO_ACTIVE_HIGH>;
 		pdn-gpios   = <&gpio1 10 GPIO_ACTIVE_HIGH>;
 		tx-en-gpios = <&gpio0 30 GPIO_ACTIVE_HIGH>;
+		spi-if = <&nrf_radio_fem_spi>;
 	};
 
 	aliases {
@@ -180,7 +181,7 @@
 		int1-gpios = <&gpio0 23 0>;
 	};
 
-	nrf21540fem: spi-dev-nrf21540fem@2 {
+	nrf_radio_fem_spi: fem_spi@2 {
 		compatible = "nordic,nrf21540-fem-spi";
 		status = "okay";
 		reg = <2>;
diff --git a/boards/arm/thingy53_nrf5340/thingy53_nrf5340_cpunet.dts b/boards/arm/thingy53_nrf5340/thingy53_nrf5340_cpunet.dts
index e1c9cdb00a8..da48526095b 100644
--- a/boards/arm/thingy53_nrf5340/thingy53_nrf5340_cpunet.dts
+++ b/boards/arm/thingy53_nrf5340/thingy53_nrf5340_cpunet.dts
@@ -50,12 +50,12 @@
 		};
 	};
 
-	nrf_radio_fem: nrf21540_fem {
+	nrf_radio_fem: fem {
 		compatible = "nordic,nrf21540-fem";
-		rx-en-gpios = <&gpio1 11 (GPIO_PULL_DOWN | GPIO_ACTIVE_HIGH)>;
-		mode-gpios = <&gpio1 12 (GPIO_PULL_DOWN | GPIO_ACTIVE_HIGH)>;
-		pdn-gpios = <&gpio1 10 (GPIO_PULL_DOWN | GPIO_ACTIVE_HIGH)>;
-		tx-en-gpios = <&gpio0 30 (GPIO_PULL_DOWN | GPIO_ACTIVE_HIGH)>;
+		rx-en-gpios = <&gpio1 11 GPIO_ACTIVE_HIGH>;
+		mode-gpios  = <&gpio1 12 GPIO_ACTIVE_HIGH>;
+		pdn-gpios   = <&gpio1 10 GPIO_ACTIVE_HIGH>;
+		tx-en-gpios = <&gpio0 30 GPIO_ACTIVE_HIGH>;
 	};
 
 	aliases {