diff --git a/drivers/serial/Kconfig.ns16550 b/drivers/serial/Kconfig.ns16550
index ae8f866a3e3..bef4e778d6e 100644
--- a/drivers/serial/Kconfig.ns16550
+++ b/drivers/serial/Kconfig.ns16550
@@ -72,6 +72,16 @@ config UART_NS16550_SIMULT_ACCESS
 	  When enabled, NS16550 supports IO, MMIO, PCIe UART devices simultaneously.
 	  For io-mapped instances, io-mapped DTS property need to be added in dtsi.
 
+config UART_NS16550_PARENT_INIT_LEVEL
+	bool "Boot level based on parent node"
+	default y if ACPI
+	help
+	  Boot level based on parent node (PCI or no PCI device). Some platforms the
+	  PCI bus driver depends on ACPI sub system to retrieve platform information
+	  such as interrupt routing information. But ACPI sub system currently support
+	  only post kernel and hence such platforms the UART driver instance init
+	  should be invoked only post kernel in case parent node is PCI.
+
 menu "NS16550 Workarounds"
 
 config UART_NS16550_WA_ISR_REENABLE_INTERRUPT
diff --git a/drivers/serial/uart_ns16550.c b/drivers/serial/uart_ns16550.c
index 08619561570..0456b354c4e 100644
--- a/drivers/serial/uart_ns16550.c
+++ b/drivers/serial/uart_ns16550.c
@@ -1248,6 +1248,15 @@ static const struct uart_driver_api uart_ns16550_driver_api = {
 #define DEV_DATA_DLF_INIT(n) \
 	_CONCAT(DEV_DATA_DLF, DT_INST_NODE_HAS_PROP(n, dlf))(n)
 
+#ifdef CONFIG_UART_NS16550_PARENT_INIT_LEVEL
+#define NS16550_BOOT_LEVEL0 PRE_KERNEL_1
+#define NS16550_BOOT_LEVEL1 POST_KERNEL
+#define BOOT_LEVEL(n) \
+	_CONCAT(NS16550_BOOT_LEVEL, DT_INST_ON_BUS(n, pcie))
+#else
+#define BOOT_LEVEL(n) PRE_KERNEL_1
+#endif
+
 #define UART_NS16550_DEVICE_INIT(n)                                                  \
 	UART_NS16550_IRQ_FUNC_DECLARE(n);                                            \
 	DEV_PCIE_DECLARE(n);                                                         \
@@ -1283,7 +1292,7 @@ static const struct uart_driver_api uart_ns16550_driver_api = {
 	};                                                                           \
 	DEVICE_DT_INST_DEFINE(n, &uart_ns16550_init, NULL,                           \
 			      &uart_ns16550_dev_data_##n, &uart_ns16550_dev_cfg_##n, \
-			      PRE_KERNEL_1, CONFIG_SERIAL_INIT_PRIORITY,             \
+			      BOOT_LEVEL(n), CONFIG_SERIAL_INIT_PRIORITY,             \
 			      &uart_ns16550_driver_api);                             \
 	UART_NS16550_IRQ_FUNC_DEFINE(n)