diff --git a/drivers/serial/uart_stm32.c b/drivers/serial/uart_stm32.c
index dd79612322d..097ba70c1b6 100644
--- a/drivers/serial/uart_stm32.c
+++ b/drivers/serial/uart_stm32.c
@@ -1279,7 +1279,8 @@ static void uart_stm32_isr(const struct device *dev)
 	uart_stm32_err_check(dev);
 #endif /* CONFIG_UART_ASYNC_API */
 
-#ifdef CONFIG_PM
+#if defined(CONFIG_PM) && defined(IS_UART_WAKEUP_FROMSTOP_INSTANCE) \
+	&& defined(USART_CR3_WUFIE)
 	if (LL_USART_IsEnabledIT_WKUP(config->usart) &&
 		LL_USART_IsActiveFlag_WKUP(config->usart)) {
 
@@ -2017,13 +2018,14 @@ static int uart_stm32_init(const struct device *dev)
 		 * CONFIG_PM_DEVICE=n : Always active
 		 * CONFIG_PM_DEVICE=y : Controlled by pm_device_wakeup_enable()
 		 */
-
+#ifdef USART_CR3_WUFIE
 		LL_USART_Disable(config->usart);
 		LL_USART_SetWKUPType(config->usart, LL_USART_WAKEUP_ON_RXNE);
 		LL_USART_EnableIT_WKUP(config->usart);
 		LL_USART_ClearFlag_WKUP(config->usart);
-		LL_USART_EnableInStopMode(config->usart);
 		LL_USART_Enable(config->usart);
+#endif
+		LL_USART_EnableInStopMode(config->usart);
 
 		if (config->wakeup_line != STM32_EXTI_LINE_NONE) {
 			/* Prepare the WAKEUP with the expected EXTI line */