diff --git a/drivers/disk/nvme/nvme_disk.c b/drivers/disk/nvme/nvme_disk.c
index 3308e04db5b..834a6e2e6c7 100644
--- a/drivers/disk/nvme/nvme_disk.c
+++ b/drivers/disk/nvme/nvme_disk.c
@@ -34,6 +34,11 @@ static int nvme_disk_read(struct disk_info *disk,
 	uint32_t payload_size;
 	int ret = 0;
 
+	if (!NVME_IS_BUFFER_DWORD_ALIGNED(data_buf)) {
+		LOG_WRN("Data buffer pointer needs to be 4-bytes aligned");
+		return -EINVAL;
+	}
+
 	nvme_lock(disk->dev);
 
 	payload_size = num_sector * nvme_namespace_get_sector_size(ns);
@@ -78,6 +83,11 @@ static int nvme_disk_write(struct disk_info *disk,
 	uint32_t payload_size;
 	int ret = 0;
 
+	if (!NVME_IS_BUFFER_DWORD_ALIGNED(data_buf)) {
+		LOG_WRN("Data buffer pointer needs to be 4-bytes aligned");
+		return -EINVAL;
+	}
+
 	nvme_lock(disk->dev);
 
 	payload_size = num_sector * nvme_namespace_get_sector_size(ns);
diff --git a/drivers/disk/nvme/nvme_helpers.h b/drivers/disk/nvme/nvme_helpers.h
index fb8165be519..325c6e9b842 100644
--- a/drivers/disk/nvme/nvme_helpers.h
+++ b/drivers/disk/nvme/nvme_helpers.h
@@ -514,4 +514,6 @@ enum shst_value {
 			    (mm_reg_t)b_a + nvme_mmio_offsetof(reg) + 4); \
 	} while (0)
 
+#define NVME_IS_BUFFER_DWORD_ALIGNED(_buf_addr) (!((uintptr_t)_buf_addr & 0x3))
+
 #endif /* ZEPHYR_DRIVERS_DISK_NVME_NHME_HELPERS_H_ */