diff --git a/drivers/serial/serial_esp32_usb.c b/drivers/serial/serial_esp32_usb.c
index 5466424dc89..2266866700d 100644
--- a/drivers/serial/serial_esp32_usb.c
+++ b/drivers/serial/serial_esp32_usb.c
@@ -75,6 +75,10 @@ static int serial_esp32_usb_init(const struct device *dev)
 	const struct serial_esp32_usb_config *config = dev->config;
 	struct serial_esp32_usb_data *data = dev->data;
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	int ret = clock_control_on(config->clock_dev, config->clock_subsys);
 
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
diff --git a/drivers/serial/uart_esp32.c b/drivers/serial/uart_esp32.c
index 5787704cc53..e1844ae9c5d 100644
--- a/drivers/serial/uart_esp32.c
+++ b/drivers/serial/uart_esp32.c
@@ -201,6 +201,10 @@ static int uart_esp32_configure(const struct device *dev, const struct uart_conf
 		return ret;
 	}
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	clock_control_on(config->clock_dev, config->clock_subsys);
 
 	uart_hal_set_sclk(&data->hal, UART_SCLK_APB);
diff --git a/drivers/serial/uart_lpc11u6x.c b/drivers/serial/uart_lpc11u6x.c
index 3f7115051d9..ffe4cd16fd4 100644
--- a/drivers/serial/uart_lpc11u6x.c
+++ b/drivers/serial/uart_lpc11u6x.c
@@ -347,6 +347,10 @@ static int lpc11u6x_uart0_init(const struct device *dev)
 		return err;
 	}
 
+	if (!device_is_ready(cfg->clock_dev)) {
+		return -ENODEV;
+	}
+
 	clock_control_on(cfg->clock_dev, (clock_control_subsys_t) cfg->clkid);
 
 	/* Configure baudrate, parity and stop bits */
diff --git a/drivers/serial/uart_mcux.c b/drivers/serial/uart_mcux.c
index 455470121c4..1a71e8fd015 100644
--- a/drivers/serial/uart_mcux.c
+++ b/drivers/serial/uart_mcux.c
@@ -46,6 +46,10 @@ static int uart_mcux_configure(const struct device *dev,
 	uint32_t clock_freq;
 	status_t retval;
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
 		return -EINVAL;
diff --git a/drivers/serial/uart_mcux_flexcomm.c b/drivers/serial/uart_mcux_flexcomm.c
index ffbb0e2dd4e..4eea0f3740e 100644
--- a/drivers/serial/uart_mcux_flexcomm.c
+++ b/drivers/serial/uart_mcux_flexcomm.c
@@ -265,6 +265,10 @@ static int mcux_flexcomm_init(const struct device *dev)
 	}
 #endif /* CONFIG_PINCTRL */
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	/* Get the clock frequency */
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
diff --git a/drivers/serial/uart_mcux_iuart.c b/drivers/serial/uart_mcux_iuart.c
index 4225d337f63..b940bc6c301 100644
--- a/drivers/serial/uart_mcux_iuart.c
+++ b/drivers/serial/uart_mcux_iuart.c
@@ -227,6 +227,10 @@ static int mcux_iuart_init(const struct device *dev)
 	uint32_t clock_freq;
 	int err;
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
 		return -EINVAL;
diff --git a/drivers/serial/uart_mcux_lpsci.c b/drivers/serial/uart_mcux_lpsci.c
index 35faa4b54ce..10649420df1 100644
--- a/drivers/serial/uart_mcux_lpsci.c
+++ b/drivers/serial/uart_mcux_lpsci.c
@@ -241,6 +241,10 @@ static int mcux_lpsci_init(const struct device *dev)
 	uint32_t clock_freq;
 	int err;
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
 		return -EINVAL;
diff --git a/drivers/serial/uart_mcux_lpuart.c b/drivers/serial/uart_mcux_lpuart.c
index b28099b29df..7214dff8631 100644
--- a/drivers/serial/uart_mcux_lpuart.c
+++ b/drivers/serial/uart_mcux_lpuart.c
@@ -883,6 +883,10 @@ static int mcux_lpuart_configure_init(const struct device *dev, const struct uar
 	struct mcux_lpuart_data *data = dev->data;
 	uint32_t clock_freq;
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
 		return -EINVAL;
diff --git a/drivers/serial/uart_npcx.c b/drivers/serial/uart_npcx.c
index 2247912ac55..c609a26026e 100644
--- a/drivers/serial/uart_npcx.c
+++ b/drivers/serial/uart_npcx.c
@@ -434,6 +434,11 @@ static int uart_npcx_init(const struct device *dev)
 	uint32_t uart_rate;
 	int ret;
 
+	if (!device_is_ready(clk_dev)) {
+		LOG_ERR("clock control device not ready");
+		return -ENODEV;
+	}
+
 	/* Turn on device clock first and get source clock freq. */
 	ret = clock_control_on(clk_dev, (clock_control_subsys_t *)&config->clk_cfg);
 	if (ret < 0) {
diff --git a/drivers/serial/uart_ns16550.c b/drivers/serial/uart_ns16550.c
index 843c0265441..c698175813d 100644
--- a/drivers/serial/uart_ns16550.c
+++ b/drivers/serial/uart_ns16550.c
@@ -377,7 +377,7 @@ static int uart_ns16550_configure(const struct device *dev,
 	if (dev_cfg->sys_clk_freq != 0U) {
 		pclk = dev_cfg->sys_clk_freq;
 	} else {
-		if (dev_cfg->clock_dev == NULL) {
+		if (!device_is_ready(dev_cfg->clock_dev)) {
 			ret = -EINVAL;
 			goto out;
 		}
diff --git a/drivers/serial/uart_rcar.c b/drivers/serial/uart_rcar.c
index d542f264867..86672655397 100644
--- a/drivers/serial/uart_rcar.c
+++ b/drivers/serial/uart_rcar.c
@@ -273,6 +273,10 @@ static int uart_rcar_init(const struct device *dev)
 		return ret;
 	}
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	ret = clock_control_on(config->clock_dev,
 			       (clock_control_subsys_t *)&config->mod_clk);
 	if (ret < 0) {
diff --git a/drivers/serial/uart_rv32m1_lpuart.c b/drivers/serial/uart_rv32m1_lpuart.c
index e4ac6c7af43..a9d6d6bd87b 100644
--- a/drivers/serial/uart_rv32m1_lpuart.c
+++ b/drivers/serial/uart_rv32m1_lpuart.c
@@ -254,6 +254,10 @@ static int rv32m1_lpuart_init(const struct device *dev)
 	/* TODO: Don't change if another core has configured */
 	CLOCK_SetIpSrc(config->clock_ip_name, config->clock_ip_src);
 
+	if (!device_is_ready(config->clock_dev)) {
+		return -ENODEV;
+	}
+
 	if (clock_control_get_rate(config->clock_dev, config->clock_subsys,
 				   &clock_freq)) {
 		return -EINVAL;
diff --git a/drivers/serial/uart_stm32.c b/drivers/serial/uart_stm32.c
index 5c8ab00850b..3d030bbe851 100644
--- a/drivers/serial/uart_stm32.c
+++ b/drivers/serial/uart_stm32.c
@@ -1563,6 +1563,12 @@ static int uart_stm32_init(const struct device *dev)
 	int err;
 
 	__uart_stm32_get_clock(dev);
+
+	if (!device_is_ready(data->clock)) {
+		LOG_ERR("clock control device not ready");
+		return -ENODEV;
+	}
+
 	/* enable clock */
 	err = clock_control_on(data->clock, (clock_control_subsys_t)&config->pclken[0]);
 	if (err != 0) {