diff --git a/samples/drivers/mbox/CMakeLists.txt b/samples/drivers/mbox/CMakeLists.txt
index e4fbfb89dee..658a18ac21f 100644
--- a/samples/drivers/mbox/CMakeLists.txt
+++ b/samples/drivers/mbox/CMakeLists.txt
@@ -18,6 +18,7 @@ if(CONFIG_BOARD_NRF5340DK_NRF5340_CPUAPP OR
    CONFIG_BOARD_MIMXRT1160_EVK_MIMXRT1166_CM7 OR
    CONFIG_BOARD_LPCXPRESSO55S69_LPC55S69_CPU0 OR
    CONFIG_BOARD_NRF54H20DK_NRF54H20_CPUAPP OR
+   CONFIG_BOARD_NRF54H20DK_NRF54H20_CPURAD OR
    CONFIG_BOARD_NRF54L15PDK_NRF54L15_CPUAPP OR
    CONFIG_BOARD_STM32H747I_DISCO_STM32H747XX_M7)
   message(STATUS "${BOARD}${BOARD_QUALIFIERS} compile as Main in this sample")
diff --git a/samples/drivers/mbox/Kconfig.sysbuild b/samples/drivers/mbox/Kconfig.sysbuild
index 080bea5b665..077fb85db64 100644
--- a/samples/drivers/mbox/Kconfig.sysbuild
+++ b/samples/drivers/mbox/Kconfig.sysbuild
@@ -14,6 +14,7 @@ string
 	default "mimxrt1170_evk/mimxrt1176/cm4" if $(BOARD) = "mimxrt1170_evk"
 	default "mimxrt1160_evk/mimxrt1166/cm4" if $(BOARD) = "mimxrt1160_evk"
 	default "lpcxpresso55s69/lpc55s69/cpu1" if $(BOARD) = "lpcxpresso55s69"
-	default "nrf54h20dk/nrf54h20/cpuppr" if $(BOARD) = "nrf54h20dk"
+	default "nrf54h20dk/nrf54h20/cpuppr" if "$(BOARD)${BOARD_QUALIFIERS}" = "nrf54h20dk/nrf54h20/cpuapp"
+	default "nrf54h20dk/nrf54h20/cpuapp" if "$(BOARD)${BOARD_QUALIFIERS}" = "nrf54h20dk/nrf54h20/cpurad"
 	default "nrf54l15pdk/nrf54l15/cpuflpr" if $(BOARD) = "nrf54l15pdk"
 	default "stm32h747i_disco/stm32h747xx/m4" if $(BOARD) = "stm32h747i_disco"
diff --git a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.overlay b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
similarity index 62%
rename from samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.overlay
rename to samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 53eec7c680c..2e5aba6d2f0 100644
--- a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.overlay
+++ b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -6,11 +6,15 @@
 / {
 	mbox-consumer {
 		compatible = "vnd,mbox-consumer";
-		mboxes = <&cpuapp_bellboard 0>;
-		mbox-names = "tx";
+		mboxes = <&cpuppr_vevif 15>, <&cpuapp_bellboard 18>;
+		mbox-names = "tx", "rx";
 	};
 };
 
 &cpuapp_bellboard {
 	status = "okay";
 };
+
+&cpuppr_vevif {
+	status = "okay";
+};
diff --git a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.conf b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.conf
deleted file mode 100644
index 0b6bc73d6bc..00000000000
--- a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_TX_ENABLED=n
diff --git a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.conf b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.conf
deleted file mode 100644
index 4596bc3a757..00000000000
--- a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_RX_ENABLED=n
diff --git a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.overlay b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpurad.overlay
similarity index 54%
rename from samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.overlay
rename to samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index 365469e86bd..d2230e8ef20 100644
--- a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.overlay
+++ b/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -6,11 +6,15 @@
 / {
 	mbox-consumer {
 		compatible = "vnd,mbox-consumer";
-		mboxes = <&cpuppr_vevif 4>;
-		mbox-names = "rx";
+		mboxes = <&cpuapp_bellboard 18>, <&cpurad_bellboard 12>;
+		mbox-names = "tx", "rx";
 	};
 };
 
-&cpuppr_vevif {
+&cpuapp_bellboard {
+	status = "okay";
+};
+
+&cpurad_bellboard {
 	status = "okay";
 };
diff --git a/samples/drivers/mbox/remote/CMakeLists.txt b/samples/drivers/mbox/remote/CMakeLists.txt
index 08823f7b0fc..efaa24db0ce 100644
--- a/samples/drivers/mbox/remote/CMakeLists.txt
+++ b/samples/drivers/mbox/remote/CMakeLists.txt
@@ -16,6 +16,7 @@ if(CONFIG_BOARD_NRF5340DK_NRF5340_CPUNET OR
    CONFIG_BOARD_MIMXRT1160_EVK_MIMXRT1166_CM4 OR
    CONFIG_BOARD_LPCXPRESSO55S69_LPC55S69_CPU1 OR
    CONFIG_BOARD_NRF54H20DK_NRF54H20_CPUPPR OR
+   CONFIG_BOARD_NRF54H20DK_NRF54H20_CPUAPP OR
    CONFIG_BOARD_NRF54L15PDK_NRF54L15_CPUFLPR OR
    CONFIG_BOARD_NRF54L15PDK_NRF54L15_CPUFLPR_XIP OR
    CONFIG_BOARD_STM32H747I_DISCO_STM32H747XX_M4)
diff --git a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.overlay b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
similarity index 54%
rename from samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.overlay
rename to samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 4e01f9a79d5..899a7cb40a7 100644
--- a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_vevif.overlay
+++ b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -6,11 +6,15 @@
 / {
 	mbox-consumer {
 		compatible = "vnd,mbox-consumer";
-		mboxes = <&cpuppr_vevif 4>;
-		mbox-names = "tx";
+		mboxes = <&cpuapp_bellboard 18>, <&cpurad_bellboard 12>;
+		mbox-names = "rx", "tx";
 	};
 };
 
-&cpuppr_vevif {
+&cpuapp_bellboard {
+	status = "okay";
+};
+
+&cpurad_bellboard {
 	status = "okay";
 };
diff --git a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.overlay b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
similarity index 62%
rename from samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.overlay
rename to samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
index 3618aab1d16..049f2432695 100644
--- a/samples/drivers/mbox/boards/nrf54h20dk_nrf54h20_cpuapp_bellboard.overlay
+++ b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
@@ -6,11 +6,15 @@
 / {
 	mbox-consumer {
 		compatible = "vnd,mbox-consumer";
-		mboxes = <&cpuapp_bellboard 0>;
-		mbox-names = "rx";
+		mboxes = <&cpuppr_vevif 15>, <&cpuapp_bellboard 18>;
+		mbox-names = "rx", "tx";
 	};
 };
 
 &cpuapp_bellboard {
 	status = "okay";
 };
+
+&cpuppr_vevif {
+	status = "okay";
+};
diff --git a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.conf b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.conf
deleted file mode 100644
index 4596bc3a757..00000000000
--- a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_bellboard.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_RX_ENABLED=n
diff --git a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.conf b/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.conf
deleted file mode 100644
index 0b6bc73d6bc..00000000000
--- a/samples/drivers/mbox/remote/boards/nrf54h20dk_nrf54h20_cpuppr_vevif.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_TX_ENABLED=n
diff --git a/samples/drivers/mbox/sample.yaml b/samples/drivers/mbox/sample.yaml
index 8308e5907d8..01646f040bc 100644
--- a/samples/drivers/mbox/sample.yaml
+++ b/samples/drivers/mbox/sample.yaml
@@ -24,13 +24,12 @@ tests:
         - "Ping \\(on channel 1\\)"
         - "Pong \\(on channel 1\\)"
 
-  sample.drivers.mbox.nrf54h20_vevif:
+  sample.drivers.mbox.nrf54h20_app_ppr:
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
     integration_platforms:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
-      FILE_SUFFIX=vevif
       mbox_SNIPPET=nordic-ppr
     sysbuild: true
     harness: console
@@ -38,23 +37,22 @@ tests:
       type: multi_line
       ordered: false
       regex:
-        - "Ping \\(on channel 4\\)"
+        - "Ping \\(on channel 15\\)"
+        - "Pong \\(on channel 18\\)"
 
-  sample.drivers.mbox.nrf54h20_bellboard:
+  sample.drivers.mbox.nrf54h20_rad_app:
     platform_allow:
-      - nrf54h20dk/nrf54h20/cpuapp
+      - nrf54h20dk/nrf54h20/cpurad
     integration_platforms:
-      - nrf54h20dk/nrf54h20/cpuapp
-    extra_args:
-      FILE_SUFFIX=bellboard
-      mbox_SNIPPET=nordic-ppr
+      - nrf54h20dk/nrf54h20/cpurad
     sysbuild: true
     harness: console
     harness_config:
       type: multi_line
       ordered: false
       regex:
-        - "Pong \\(on channel 0\\)"
+        - "Ping \\(on channel 18\\)"
+        - "Pong \\(on channel 12\\)"
 
   sample.drivers.mbox.simu:
     platform_allow:
diff --git a/samples/drivers/mbox/sysbuild.cmake b/samples/drivers/mbox/sysbuild.cmake
index 769d33d3f77..e2a5a03b87e 100644
--- a/samples/drivers/mbox/sysbuild.cmake
+++ b/samples/drivers/mbox/sysbuild.cmake
@@ -4,7 +4,7 @@
 
 if("${SB_CONFIG_REMOTE_BOARD}" STREQUAL "")
 	message(FATAL_ERROR
-	"Target ${BOARD} not supported for this sample. "
+	"Target ${BOARD}${BOARD_QUALIFIERS} not supported for this sample. "
 	"There is no remote board selected in Kconfig.sysbuild")
 endif()