diff --git a/boards/arm/npcx7m6fb_evb/npcx7m6fb_evb.dts b/boards/arm/npcx7m6fb_evb/npcx7m6fb_evb.dts
index debcc367de5..ca2eb8c3fa7 100644
--- a/boards/arm/npcx7m6fb_evb/npcx7m6fb_evb.dts
+++ b/boards/arm/npcx7m6fb_evb/npcx7m6fb_evb.dts
@@ -70,7 +70,9 @@
 &uart1 {
 	status = "okay";
 	current-speed = <115200>;
-	pinctrl-0 = <&altc_uart1_sl2>; /* Use UART1_SL2 ie. PIN64.65 */
+	/* Use UART1_SL2 ie. PIN64.65 */
+	pinctrl-0 = <&uart1_2_sin_sout_gp64_65>;
+	pinctrl-names = "default";
 };
 
 &pwm6 {
diff --git a/boards/arm/npcx9m6f_evb/npcx9m6f_evb.dts b/boards/arm/npcx9m6f_evb/npcx9m6f_evb.dts
index 5911bfae827..871eee84fa9 100644
--- a/boards/arm/npcx9m6f_evb/npcx9m6f_evb.dts
+++ b/boards/arm/npcx9m6f_evb/npcx9m6f_evb.dts
@@ -83,7 +83,9 @@
 	status = "okay";
 	current-speed = <115200>;
 	/* Use UART1_SL2 ie. PIN64.65 */
-	pinctrl-0 = <&altj_cr_sin1_sl2 &altj_cr_sout1_sl2>;
+	pinctrl-0 = <&uart1_2_sin_gp64
+		     &uart1_2_sout_gp65>;
+	pinctrl-names = "default";
 };
 
 &pwm6 {
diff --git a/drivers/serial/uart_npcx.c b/drivers/serial/uart_npcx.c
index 722a15b6bd4..2247912ac55 100644
--- a/drivers/serial/uart_npcx.c
+++ b/drivers/serial/uart_npcx.c
@@ -8,6 +8,7 @@
 
 #include <zephyr/sys/__assert.h>
 #include <zephyr/drivers/gpio.h>
+#include <zephyr/drivers/pinctrl.h>
 #include <zephyr/drivers/uart.h>
 #include <zephyr/drivers/clock_control.h>
 #include <zephyr/kernel.h>
@@ -31,8 +32,7 @@ struct uart_npcx_config {
 	/* int-mux configuration */
 	const struct npcx_wui uart_rx_wui;
 	/* pinmux configuration */
-	const uint8_t alts_size;
-	const struct npcx_alt *alts_list;
+	const struct pinctrl_dev_config *pcfg;
 };
 
 enum uart_pm_policy_state_flag {
@@ -499,7 +499,11 @@ static int uart_npcx_init(const struct device *dev)
 	}
 
 	/* Configure pin-mux for uart device */
-	npcx_pinctrl_mux_configure(config->alts_list, config->alts_size, 1);
+	ret = pinctrl_apply_state(config->pcfg, PINCTRL_STATE_DEFAULT);
+	if (ret < 0) {
+		LOG_ERR("UART pinctrl setup failed (%d)", ret);
+		return ret;
+	}
 
 	return 0;
 }
@@ -524,14 +528,13 @@ static int uart_npcx_init(const struct device *dev)
 #define NPCX_UART_INIT(i)                                                                       \
 	NPCX_UART_IRQ_CONFIG_FUNC_DECL(i);                                                      \
 												\
-	static const struct npcx_alt uart_alts##i[] = NPCX_DT_ALT_ITEMS_LIST(i);                \
+	PINCTRL_DT_INST_DEFINE(i);                                                              \
 												\
 	static const struct uart_npcx_config uart_npcx_cfg_##i = {                              \
 		.inst = (struct uart_reg *)DT_INST_REG_ADDR(i),                                 \
 		.clk_cfg = NPCX_DT_CLK_CFG_ITEM(i),                                             \
 		.uart_rx_wui = NPCX_DT_WUI_ITEM_BY_NAME(0, uart_rx),                            \
-		.alts_size = ARRAY_SIZE(uart_alts##i),                                          \
-		.alts_list = uart_alts##i,                                                      \
+		.pcfg = PINCTRL_DT_INST_DEV_CONFIG_GET(i),                                      \
 		NPCX_UART_IRQ_CONFIG_FUNC_INIT(i)                                               \
 	};                                                                                      \
 												\
diff --git a/dts/arm/nuvoton/npcx7.dtsi b/dts/arm/nuvoton/npcx7.dtsi
index 0a48e7040cc..80c2bf3fd60 100644
--- a/dts/arm/nuvoton/npcx7.dtsi
+++ b/dts/arm/nuvoton/npcx7.dtsi
@@ -76,7 +76,6 @@
 			reg = <0x400C4000 0x2000>;
 			interrupts = <33 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB2 NPCX_PWDWN_CTL1 4>;
-			pinctrl-0 = <&alta_uart1_sl1>; /* PIN10.11 */
 			uart-rx = <&wui_cr_sin1>;
 			status = "disabled";
 			label = "UART_1";
@@ -87,7 +86,6 @@
 			reg = <0x400C6000 0x2000>;
 			interrupts = <32 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB2 NPCX_PWDWN_CTL7 6>;
-			pinctrl-0 = <&alta_uart2_sl>; /* PIN75.86 */
 			uart-rx = <&wui_cr_sin2>;
 			status = "disabled";
 			label = "UART_2";
diff --git a/dts/arm/nuvoton/npcx9.dtsi b/dts/arm/nuvoton/npcx9.dtsi
index 49d7dac2e31..0c3a9f6c59d 100644
--- a/dts/arm/nuvoton/npcx9.dtsi
+++ b/dts/arm/nuvoton/npcx9.dtsi
@@ -77,7 +77,6 @@
 			reg = <0x400E0000 0x2000>;
 			interrupts = <33 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB4 NPCX_PWDWN_CTL1 4>;
-			pinctrl-0 = <&altj_cr_sin1_sl1 &altj_cr_sout1_sl1>; /* PIN10.11 */
 			uart-rx = <&wui_cr_sin1>;
 			status = "disabled";
 			label = "UART_1";
@@ -88,7 +87,6 @@
 			reg = <0x400E2000 0x2000>;
 			interrupts = <32 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB4 NPCX_PWDWN_CTL7 6>;
-			pinctrl-0 = <&altj_cr_sin2_sl &altj_cr_sout2_sl>; /* PIN75.86 */
 			uart-rx = <&wui_cr_sin2>;
 			status = "disabled";
 			label = "UART_2";
@@ -99,7 +97,6 @@
 			reg = <0x400E4000 0x2000>;
 			interrupts = <38 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB4 NPCX_PWDWN_CTL7 4>;
-			pinctrl-0 = <&altj_cr_sin3_sl &altj_cr_sout3_sl>; /* PIND3.D6 */
 			uart-rx = <&wui_cr_sin3>;
 			status = "disabled";
 			label = "UART_3";
@@ -110,7 +107,6 @@
 			reg = <0x400E6000 0x2000>;
 			interrupts = <39 3>;
 			clocks = <&pcc NPCX_CLOCK_BUS_APB4 NPCX_PWDWN_CTL7 3>;
-			pinctrl-0 = <&alte_cr_sin4_sl &alte_cr_sout4_sl>; /* PIN17.35 */
 			uart-rx = <&wui_cr_sin4>;
 			status = "disabled";
 			label = "UART_4";
diff --git a/dts/bindings/serial/nuvoton,npcx-uart.yaml b/dts/bindings/serial/nuvoton,npcx-uart.yaml
index d0e0e86d149..8b309a90d77 100644
--- a/dts/bindings/serial/nuvoton,npcx-uart.yaml
+++ b/dts/bindings/serial/nuvoton,npcx-uart.yaml
@@ -5,7 +5,7 @@ description: Nuvoton, NPCX-UART node
 
 compatible: "nuvoton,npcx-uart"
 
-include: uart-controller.yaml
+include: [uart-controller.yaml, pinctrl-device.yaml]
 
 properties:
     reg:
@@ -13,9 +13,9 @@ properties:
     clocks:
         required: true
     pinctrl-0:
-        type: phandles
         required: true
-        description: configurations of pinmux controllers
+    pinctrl-names:
+        required: true
     uart-rx:
         type: phandle
         required: true