diff --git a/samples/drivers/uart/echo_bot/src/main.c b/samples/drivers/uart/echo_bot/src/main.c
index 55623a32487..4d66abaa6f2 100644
--- a/samples/drivers/uart/echo_bot/src/main.c
+++ b/samples/drivers/uart/echo_bot/src/main.c
@@ -78,7 +78,18 @@ void main(void)
 	}
 
 	/* configure interrupt and callback to receive data */
-	uart_irq_callback_user_data_set(uart_dev, serial_cb, NULL);
+	int ret = uart_irq_callback_user_data_set(uart_dev, serial_cb, NULL);
+
+	if (ret < 0) {
+		if (ret == -ENOTSUP) {
+			printk("Interrupt-driven UART API support not enabled\n");
+		} else if (ret == -ENOSYS) {
+			printk("UART device does not support interrupt-driven API\n");
+		} else {
+			printk("Error setting UART callback: %d\n", ret);
+		}
+		return;
+	}
 	uart_irq_rx_enable(uart_dev);
 
 	print_uart("Hello! I'm your echo bot.\r\n");