diff --git a/drivers/espi/host_subs_npcx.c b/drivers/espi/host_subs_npcx.c
index 54140c31b39..b1bea00f7b8 100644
--- a/drivers/espi/host_subs_npcx.c
+++ b/drivers/espi/host_subs_npcx.c
@@ -962,6 +962,16 @@ void npcx_host_init_subs_host_domain(void)
 	LOG_DBG("Hos sub-modules configurations are done!");
 }
 
+void npcx_host_enable_access_interrupt(void)
+{
+	npcx_miwu_irq_enable(&host_sub_cfg.host_acc_wui);
+}
+
+void npcx_host_disable_access_interrupt(void)
+{
+	npcx_miwu_irq_disable(&host_sub_cfg.host_acc_wui);
+}
+
 int npcx_host_init_subs_core_domain(const struct device *host_bus_dev,
 							sys_slist_t *callbacks)
 {
@@ -1057,13 +1067,11 @@ int npcx_host_init_subs_core_domain(const struct device *host_bus_dev,
 	if (IS_ENABLED(CONFIG_PM)) {
 		/*
 		 * Configure the host access wake-up event triggered from a host
-		 * transaction on eSPI/LPC bus. No need for callback function.
+		 * transaction on eSPI/LPC bus. Do not enable it here. Or plenty
+		 * of interrupts will jam the system in S0.
 		 */
 		npcx_miwu_interrupt_configure(&host_sub_cfg.host_acc_wui,
 				NPCX_MIWU_MODE_EDGE, NPCX_MIWU_TRIG_HIGH);
-
-		/* Enable irq of interrupt-input module */
-		npcx_miwu_irq_enable(&host_sub_cfg.host_acc_wui);
 	}
 
 	return 0;
diff --git a/soc/arm/nuvoton_npcx/common/soc_host.h b/soc/arm/nuvoton_npcx/common/soc_host.h
index 719bb46641c..b7f5e94f718 100644
--- a/soc/arm/nuvoton_npcx/common/soc_host.h
+++ b/soc/arm/nuvoton_npcx/common/soc_host.h
@@ -68,6 +68,17 @@ int npcx_host_periph_read_request(enum lpc_peripheral_opcode op,
 int npcx_host_periph_write_request(enum lpc_peripheral_opcode op,
 							const uint32_t *data);
 
+/**
+ * @brief Enable host access wake-up interrupt. Usually, it is used to wake up
+ * ec during system is in Modern standby power mode.
+ */
+void npcx_host_enable_access_interrupt(void);
+
+/**
+ * @brief Disable host access wake-up interrupt.
+ */
+void npcx_host_disable_access_interrupt(void);
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/soc/arm/nuvoton_npcx/npcx7/power.c b/soc/arm/nuvoton_npcx/npcx7/power.c
index 328b6768aeb..19637edc6fa 100644
--- a/soc/arm/nuvoton_npcx/npcx7/power.c
+++ b/soc/arm/nuvoton_npcx/npcx7/power.c
@@ -46,9 +46,12 @@
  */
 
 #include <zephyr.h>
+#include <drivers/espi.h>
 #include <power/power.h>
 #include <soc.h>
 
+#include "soc_host.h"
+
 #include <logging/log.h>
 LOG_MODULE_DECLARE(soc, CONFIG_SOC_LOG_LEVEL);
 
@@ -94,6 +97,9 @@ static void npcx_power_enter_system_sleep(int slp_mode, int wk_mode)
 	npcx_clock_control_turn_on_system_sleep(slp_mode == NPCX_DEEP_SLEEP,
 					wk_mode == NPCX_INSTANT_WAKE_UP);
 
+	/* Turn on host access wake-up interrupt. */
+	npcx_host_enable_access_interrupt();
+
 	/*
 	 * Capture the reading of low-freq timer for compensation before ec
 	 * enters system sleep mode.
@@ -109,6 +115,9 @@ static void npcx_power_enter_system_sleep(int slp_mode, int wk_mode)
 	 */
 	npcx_clock_compensate_system_timer();
 
+	/* Turn off host access wake-up interrupt. */
+	npcx_host_disable_access_interrupt();
+
 	/* Turn off system sleep mode. */
 	npcx_clock_control_turn_off_system_sleep();
 }