diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-memory_map.dtsi b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-memory_map.dtsi
index 7e4f859753c..834448f33e4 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-memory_map.dtsi
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-memory_map.dtsi
@@ -3,6 +3,7 @@
  *
  * SPDX-License-Identifier: Apache-2.0
  */
+#include <zephyr/dt-bindings/memory-attr/memory-attr.h>
 
 / {
 	reserved-memory {
@@ -92,6 +93,27 @@
 			};
 		};
 
+		ram21_region: memory@2f890000 {
+			compatible = "nordic,owned-memory";
+			status = "disabled";
+			reg = <0x2f890000 DT_SIZE_K(64)>;
+			perm-read;
+			perm-write;
+			perm-secure;
+			#address-cells = <1>;
+			#size-cells = <1>;
+			ranges = <0x0 0x2f890000 0x10000>;
+
+			dma_fast_region: memory@8000 {
+				compatible = "zephyr,memory-region";
+				reg = <0x8000 DT_SIZE_K(16)>;
+				status = "disabled";
+				#memory-region-cells = <0>;
+				zephyr,memory-region = "DMA_RAM21";
+				zephyr,memory-attr = <( DT_MEM_CACHEABLE )>;
+			};
+		};
+
 		cpuppr_ram3x_region: memory@2fc00000 {
 			compatible = "nordic,owned-memory";
 			reg = <0x2fc00000 DT_SIZE_K(64)>;
diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
index 2c5d61a27e8..2b071c87038 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
@@ -108,6 +108,10 @@
 	status = "okay";
 };
 
+&ram21_region {
+	status = "okay";
+};
+
 &cpuapp_bellboard {
 	status = "okay";
 	interrupts = <96 NRF_DEFAULT_IRQ_PRIORITY>;
@@ -156,6 +160,10 @@ ipc0: &cpuapp_cpurad_ipc {
 	status = "okay";
 };
 
+&dma_fast_region {
+	status = "okay";
+};
+
 &cpuapp_rx_partitions {
 	status = "okay";
 };