diff --git a/samples/subsys/ipc/openamp/CMakeLists.txt b/samples/subsys/ipc/openamp/CMakeLists.txt
index 804fd423001..e6d6a723d87 100644
--- a/samples/subsys/ipc/openamp/CMakeLists.txt
+++ b/samples/subsys/ipc/openamp/CMakeLists.txt
@@ -5,8 +5,13 @@ cmake_minimum_required(VERSION 3.13.1)
 # SPDX-License-Identifier: Apache-2.0
 #
 
+set(REMOTE_ZEPHYR_DIR ${CMAKE_CURRENT_BINARY_DIR}/openamp_remote-prefix/src/openamp_remote-build/zephyr)
+
 if("${BOARD}" STREQUAL "lpcxpresso54114_m4")
   set(BOARD_REMOTE "lpcxpresso54114_m0")
+elseif("${BOARD}" STREQUAL "mps2_an521")
+  set(QEMU_EXTRA_FLAGS "-device;loader,file=${REMOTE_ZEPHYR_DIR}/zephyr.elf")
+  set(BOARD_REMOTE "mps2_an521_nonsecure")
 else()
   message(FATAL_ERROR "${BOARD} was not supported for this sample")
 endif()
@@ -28,7 +33,7 @@ ExternalProject_Add(
   INSTALL_COMMAND ""      # This particular build system has no install command
   CMAKE_CACHE_ARGS -DBOARD:string=${BOARD_REMOTE}
   CMAKE_CACHE_ARGS -DDTC_OVERLAY_FILE:string=${DTC_OVERLAY_FILE}
-  BUILD_BYPRODUCTS "${CMAKE_CURRENT_BINARY_DIR}/openamp_remote-prefix/src/openamp_remote-build/zephyr/zephyr.bin"
+  BUILD_BYPRODUCTS "${REMOTE_ZEPHYR_DIR}/zephyr.bin"
   # NB: Do we need to pass on more CMake variables?
   BUILD_ALWAYS True
 )
diff --git a/samples/subsys/ipc/openamp/README.rst b/samples/subsys/ipc/openamp/README.rst
index 71a3bebb8b5..757c2d0b8e3 100644
--- a/samples/subsys/ipc/openamp/README.rst
+++ b/samples/subsys/ipc/openamp/README.rst
@@ -18,6 +18,14 @@ Building the application for lpcxpresso54114_m4
    :board: lpcxpresso54114_m4
    :goals: debug
 
+Building the application for mps2_an521
+***************************************
+
+.. zephyr-app-commands::
+   :zephyr-app: samples/subsys/ipc/openamp
+   :board: mps2_an521
+   :goals: debug
+
 Open a serial terminal (minicom, putty, etc.) and connect the board with the
 following settings:
 
diff --git a/samples/subsys/ipc/openamp/mps2_an521.overlay b/samples/subsys/ipc/openamp/mps2_an521.overlay
new file mode 100644
index 00000000000..aff3c460cbc
--- /dev/null
+++ b/samples/subsys/ipc/openamp/mps2_an521.overlay
@@ -0,0 +1,20 @@
+/*
+ * Copyright (c) 2019 Linaro Limited
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/ {
+	chosen {
+		/*
+		 * shared memory reserved for the inter-processor communication
+		 */
+		zephyr,ipc_shm = &sramx;
+		zephyr,ipc = &mhu0;
+	};
+
+	sramx: memory@28180000 {
+		compatible = "mmio-sram";
+		reg = <0x28180000 0x8000>;
+	};
+};
diff --git a/samples/subsys/ipc/openamp/remote/CMakeLists.txt b/samples/subsys/ipc/openamp/remote/CMakeLists.txt
index 884de45722a..971085e2ac3 100644
--- a/samples/subsys/ipc/openamp/remote/CMakeLists.txt
+++ b/samples/subsys/ipc/openamp/remote/CMakeLists.txt
@@ -4,7 +4,9 @@ cmake_minimum_required(VERSION 3.13.1)
 #
 # SPDX-License-Identifier: Apache-2.0
 #
-if(("${BOARD}" STREQUAL "lpcxpresso54114_m0"))
+
+if(("${BOARD}" STREQUAL "lpcxpresso54114_m0")
+	OR "${BOARD}" STREQUAL "mps2_an521_nonsecure")
 	message(INFO " ${BOARD} compile as slave in this sample")
 else()
 	message(FATAL_ERROR "${BOARD} was not supported for this sample")
diff --git a/samples/subsys/ipc/openamp/remote/src/main.c b/samples/subsys/ipc/openamp/remote/src/main.c
index ac9c04bac82..c3e99453a20 100644
--- a/samples/subsys/ipc/openamp/remote/src/main.c
+++ b/samples/subsys/ipc/openamp/remote/src/main.c
@@ -73,9 +73,15 @@ static u32_t virtio_get_features(struct virtio_device *vdev)
 
 static void virtio_notify(struct virtqueue *vq)
 {
+#if defined(CONFIG_SOC_MPS2_AN521)
+	u32_t current_core = sse_200_platform_get_cpu_id();
+
+	ipm_send(ipm_handle, 0, current_core ? 0 : 1, 0, 1);
+#else
 	u32_t dummy_data = 0x00110011; /* Some data must be provided */
 
 	ipm_send(ipm_handle, 0, 0, &dummy_data, sizeof(dummy_data));
+#endif /* #if defined(CONFIG_SOC_MPS2_AN521) */
 }
 
 struct virtio_dispatch dispatch = {
diff --git a/samples/subsys/ipc/openamp/sample.yaml b/samples/subsys/ipc/openamp/sample.yaml
index 4f6d5b97f57..7d04f96407e 100644
--- a/samples/subsys/ipc/openamp/sample.yaml
+++ b/samples/subsys/ipc/openamp/sample.yaml
@@ -4,7 +4,7 @@ sample:
     name: OpenAMP example integration
 tests:
     sample.ipc.openamp:
-        platform_whitelist: lpcxpresso54114_m4
+        platform_whitelist: lpcxpresso54114_m4 mps2_an521
         tags: ipm
         harness: console
         harness_config:
diff --git a/samples/subsys/ipc/openamp/src/main.c b/samples/subsys/ipc/openamp/src/main.c
index b8c86b40ced..09adbf2c601 100644
--- a/samples/subsys/ipc/openamp/src/main.c
+++ b/samples/subsys/ipc/openamp/src/main.c
@@ -84,9 +84,15 @@ static void virtio_set_features(struct virtio_device *vdev,
 
 static void virtio_notify(struct virtqueue *vq)
 {
+#if defined(CONFIG_SOC_MPS2_AN521)
+	u32_t current_core = sse_200_platform_get_cpu_id();
+
+	ipm_send(ipm_handle, 0, current_core ? 0 : 1, 0, 1);
+#else
 	u32_t dummy_data = 0x55005500; /* Some data must be provided */
 
 	ipm_send(ipm_handle, 0, 0, &dummy_data, sizeof(dummy_data));
+#endif /* #if defined(CONFIG_SOC_MPS2_AN521) */
 }
 
 struct virtio_dispatch dispatch = {
@@ -279,6 +285,11 @@ void main(void)
 	k_thread_create(&thread_data, thread_stack, APP_TASK_STACK_SIZE,
 			(k_thread_entry_t)app_task,
 			NULL, NULL, NULL, K_PRIO_COOP(7), 0, K_NO_WAIT);
+
+#if defined(CONFIG_SOC_MPS2_AN521)
+	wakeup_cpu1();
+	k_sleep(500);
+#endif /* #if defined(CONFIG_SOC_MPS2_AN521) */
 }
 
 /* Make sure we clear out the status flag very early (before we bringup the