diff --git a/drivers/i2s/Kconfig.nrfx b/drivers/i2s/Kconfig.nrfx
index 00747b84108..404f78a15bf 100644
--- a/drivers/i2s/Kconfig.nrfx
+++ b/drivers/i2s/Kconfig.nrfx
@@ -5,7 +5,7 @@ menuconfig I2S_NRFX
 	bool "nRF I2S nrfx driver"
 	default y
 	depends on DT_HAS_NORDIC_NRF_I2S_ENABLED
-	select NRFX_I2S
+	select NRFX_I2S0 if HAS_HW_NRF_I2S0
 	help
 	  Enable support for nrfx I2S driver for nRF MCU series.
 
diff --git a/modules/hal_nordic/nrfx/Kconfig b/modules/hal_nordic/nrfx/Kconfig
index 0372aeb1045..e8f39cd3db3 100644
--- a/modules/hal_nordic/nrfx/Kconfig
+++ b/modules/hal_nordic/nrfx/Kconfig
@@ -73,8 +73,12 @@ config NRFX_GPIOTE_NUM_OF_EVT_HANDLERS
 	  by the user.
 
 config NRFX_I2S
-	bool "I2S driver"
-	depends on $(dt_has_compat,$(DT_COMPAT_NORDIC_NRF_I2S))
+	bool
+
+config NRFX_I2S0
+	bool "I2S0 driver instance"
+	depends on $(dt_nodelabel_has_compat,i2s0,$(DT_COMPAT_NORDIC_NRF_I2S))
+	select NRFX_I2S
 
 config NRFX_IPC
 	bool "IPC driver"
diff --git a/modules/hal_nordic/nrfx/nrfx_config.h b/modules/hal_nordic/nrfx/nrfx_config.h
index 7c9d39cd8d0..daf73e9fdd0 100644
--- a/modules/hal_nordic/nrfx/nrfx_config.h
+++ b/modules/hal_nordic/nrfx/nrfx_config.h
@@ -111,6 +111,9 @@
 #ifdef CONFIG_NRFX_I2S
 #define NRFX_I2S_ENABLED 1
 #endif
+#ifdef CONFIG_NRFX_I2S0
+#define NRFX_I2S0_ENABLED 1
+#endif
 
 #ifdef CONFIG_NRFX_IPC
 #define NRFX_IPC_ENABLED 1
diff --git a/soc/arm/nordic_nrf/Kconfig.peripherals b/soc/arm/nordic_nrf/Kconfig.peripherals
index de3da1f9b7d..e81d195b2a0 100644
--- a/soc/arm/nordic_nrf/Kconfig.peripherals
+++ b/soc/arm/nordic_nrf/Kconfig.peripherals
@@ -69,8 +69,8 @@ config HAS_HW_NRF_GPIO1
 config HAS_HW_NRF_GPIOTE
 	def_bool $(dt_compat_enabled,$(DT_COMPAT_NORDIC_NRF_GPIOTE))
 
-config HAS_HW_NRF_I2S
-	def_bool $(dt_compat_enabled,$(DT_COMPAT_NORDIC_NRF_I2S))
+config HAS_HW_NRF_I2S0
+	def_bool $(dt_nodelabel_enabled_with_compat,i2s0,$(DT_COMPAT_NORDIC_NRF_I2S))
 
 config HAS_HW_NRF_IPC
 	def_bool $(dt_compat_enabled,$(DT_COMPAT_NORDIC_NRF_IPC))