diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-ipc_conf.dtsi b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-ipc_conf.dtsi
index 9c3d971b9bc..abe93b34ba9 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-ipc_conf.dtsi
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20-ipc_conf.dtsi
@@ -26,11 +26,25 @@
 				 <&cpurad_bellboard 12>;
 		};
 
+		cpuapp_cpusys_ipc: ipc-2-12 {
+			compatible = "zephyr,ipc-icmsg";
+			status = "disabled";
+			mboxes = <&cpuapp_bellboard 6>,
+				 <&cpusys_vevif 12>;
+		};
+
 		cpuapp_cpuppr_ipc: ipc-2-13 {
 			compatible = "zephyr,ipc-icmsg";
 			status = "disabled";
 			mboxes = <&cpuapp_bellboard 13>,
 				 <&cpuppr_vevif 12>;
 		};
+
+		cpurad_cpusys_ipc: ipc-3-12 {
+			compatible = "zephyr,ipc-icmsg";
+			status = "disabled";
+			mboxes = <&cpurad_bellboard 6>,
+				 <&cpusys_vevif 18>;
+		};
 	};
 };
diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
index 21a7b9ca7e2..60e872141ba 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuapp.dts
@@ -11,6 +11,7 @@
 #include "nrf54h20dk_nrf54h20-ipc_conf.dtsi"
 #include "nrf54h20dk_nrf54h20-pinctrl.dtsi"
 
+/delete-node/ &cpurad_cpusys_ipc;
 /delete-node/ &cpusec_cpurad_ipc;
 
 / {
@@ -100,8 +101,8 @@
 &cpuapp_bellboard {
 	interrupts = <96 NRF_DEFAULT_IRQ_PRIORITY>;
 	interrupt-names = "irq0";
-	/* irq0: 0: cpuapp-cpusec, 13: cpuapp-cpuppr, 18: cpuapp-cpurad */
-	nordic,interrupt-mapping = <0x00042001 0>;
+	/* irq0: 0: cpuapp-cpusec, 6: cpuapp-cpusys, 13: cpuapp-cpuppr, 18: cpuapp-cpurad */
+	nordic,interrupt-mapping = <0x00042041 0>;
 };
 
 &cpusec_cpuapp_ipc {
@@ -117,6 +118,12 @@
 	rx-region = <&cpurad_cpuapp_ipc_shm>;
 };
 
+&cpuapp_cpusys_ipc {
+	mbox-names = "rx", "tx";
+	tx-region = <&cpuapp_cpusys_ipc_shm>;
+	rx-region = <&cpusys_cpuapp_ipc_shm>;
+};
+
 &cpuapp_cpuppr_ipc {
 	mbox-names = "rx", "tx";
 	tx-region = <&cpuapp_cpuppr_ipc_shm>;
diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuppr.dts b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuppr.dts
index 4cfad97323e..80b690839d7 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuppr.dts
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpuppr.dts
@@ -12,6 +12,8 @@
 #include "nrf54h20dk_nrf54h20-pinctrl.dtsi"
 
 /delete-node/ &cpuapp_cpurad_ipc;
+/delete-node/ &cpuapp_cpusys_ipc;
+/delete-node/ &cpurad_cpusys_ipc;
 /delete-node/ &cpusec_cpuapp_ipc;
 /delete-node/ &cpusec_cpurad_ipc;
 
diff --git a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpurad.dts b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpurad.dts
index a3d3736fde2..4cfeb3dbe9b 100644
--- a/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpurad.dts
+++ b/boards/nordic/nrf54h20dk/nrf54h20dk_nrf54h20_cpurad.dts
@@ -12,6 +12,7 @@
 #include "nrf54h20dk_nrf54h20-pinctrl.dtsi"
 
 /delete-node/ &cpuapp_cpuppr_ipc;
+/delete-node/ &cpuapp_cpusys_ipc;
 /delete-node/ &cpusec_cpuapp_ipc;
 
 / {
@@ -34,8 +35,8 @@
 &cpurad_bellboard {
 	interrupts = <96 NRF_DEFAULT_IRQ_PRIORITY>;
 	interrupt-names = "irq0";
-	/* irq0: 0: cpurad-cpusec, 12: cpurad-cpuapp */
-	nordic,interrupt-mapping = <0x00001001 0>;
+	/* irq0: 0: cpurad-cpusec, 6: cpurad-cpusys, 12: cpurad-cpuapp */
+	nordic,interrupt-mapping = <0x00001041 0>;
 };
 
 &cpusec_cpurad_ipc {
@@ -51,6 +52,12 @@
 	rx-region = <&cpuapp_cpurad_ipc_shm>;
 };
 
+&cpurad_cpusys_ipc {
+	mbox-names = "rx", "tx";
+	tx-region = <&cpurad_cpusys_ipc_shm>;
+	rx-region = <&cpusys_cpurad_ipc_shm>;
+};
+
 &cpurad_dma_region {
 	status = "okay";
 };