diff --git a/drivers/spi/Kconfig.nrfx b/drivers/spi/Kconfig.nrfx
index 044e3ae09c2..56df44355d3 100644
--- a/drivers/spi/Kconfig.nrfx
+++ b/drivers/spi/Kconfig.nrfx
@@ -5,6 +5,7 @@ menuconfig SPI_NRFX
 	bool "nRF SPI nrfx drivers"
 	default y
 	depends on SOC_FAMILY_NRF
+	depends on MULTITHREADING
 	help
 	  Enable support for nrfx SPI drivers for nRF MCU series.