diff --git a/drivers/bluetooth/hci/cyw43xxx.c b/drivers/bluetooth/hci/cyw43xxx.c
index be3299e9218..f1ee9ad81b1 100644
--- a/drivers/bluetooth/hci/cyw43xxx.c
+++ b/drivers/bluetooth/hci/cyw43xxx.c
@@ -26,6 +26,9 @@ LOG_MODULE_REGISTER(cyw43xxx_driver);
 
 #include <stdint.h>
 
+BUILD_ASSERT(DT_PROP(DT_CHOSEN(zephyr_bt_uart), hw_flow_control) == 1,
+		"hw_flow_control must be enabled for HCI H4 UART");
+
 #define DT_DRV_COMPAT infineon_cyw43xxx_bt_hci
 
 /* BT settling time after power on */