diff --git a/subsys/bluetooth/controller/hci/hci.c b/subsys/bluetooth/controller/hci/hci.c
index 1453a62317d..ac7ccc7ea61 100644
--- a/subsys/bluetooth/controller/hci/hci.c
+++ b/subsys/bluetooth/controller/hci/hci.c
@@ -3728,16 +3728,23 @@ static void le_cis_request(struct pdu_data *pdu_data,
 {
 	struct bt_hci_evt_le_cis_req *sep;
 	struct node_rx_conn_iso_req *req;
+	void *node;
 
 	if (!(event_mask & BT_EVT_MASK_LE_META_EVENT) ||
 	    !(le_event_mask & BT_EVT_MASK_LE_CIS_REQ)) {
 		return;
 	}
 
-	req = (void *)pdu_data;
-
 	sep = meta_evt(buf, BT_HCI_EVT_LE_CIS_REQ, sizeof(*sep));
 	sep->acl_handle = sys_cpu_to_le16(node_rx->hdr.handle);
+
+	/* Check for pdu field being aligned before accessing CIS established
+	 * event.
+	 */
+	node = pdu_data;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_conn_iso_estab));
+
+	req = node;
 	sep->cis_handle = sys_cpu_to_le16(req->cis_handle);
 	sep->cig_id = req->cig_id;
 	sep->cis_id = req->cis_id;
@@ -3757,6 +3764,7 @@ static void le_cis_established(struct pdu_data *pdu_data,
 	struct ll_conn_iso_stream *cis;
 	struct ll_conn_iso_group *cig;
 	bool is_central;
+	void *node;
 
 	if (!(event_mask & BT_EVT_MASK_LE_META_EVENT) ||
 	    !(le_event_mask & BT_EVT_MASK_LE_CIS_ESTABLISHED)) {
@@ -3769,10 +3777,16 @@ static void le_cis_established(struct pdu_data *pdu_data,
 	is_central = cig->lll.role == BT_CONN_ROLE_CENTRAL;
 	lll_cis_c = is_central ? &lll_cis->tx : &lll_cis->rx;
 	lll_cis_p = is_central ? &lll_cis->rx : &lll_cis->tx;
-	est = (void *)pdu_data;
 
 	sep = meta_evt(buf, BT_HCI_EVT_LE_CIS_ESTABLISHED, sizeof(*sep));
 
+	/* Check for pdu field being aligned before accessing CIS established
+	 * event.
+	 */
+	node = pdu_data;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_conn_iso_estab));
+
+	est = node;
 	sep->status = est->status;
 	sep->conn_handle = sys_cpu_to_le16(est->cis_handle);
 	sys_put_le24(cig->sync_delay, sep->cig_sync_delay);
@@ -6063,6 +6077,7 @@ static void le_per_adv_sync_established(struct pdu_data *pdu_data,
 	struct bt_hci_evt_le_per_adv_sync_established *sep;
 	struct ll_scan_set *scan;
 	struct node_rx_sync *se;
+	void *node;
 
 	if (!(event_mask & BT_EVT_MASK_LE_META_EVENT) ||
 	    !(le_event_mask & BT_EVT_MASK_LE_PER_ADV_SYNC_ESTABLISHED)) {
@@ -6072,7 +6087,13 @@ static void le_per_adv_sync_established(struct pdu_data *pdu_data,
 	sep = meta_evt(buf, BT_HCI_EVT_LE_PER_ADV_SYNC_ESTABLISHED,
 		       sizeof(*sep));
 
-	se = (void *)pdu_data;
+	/* Check for pdu field being aligned before accessing sync established
+	 * event.
+	 */
+	node = pdu_data;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_sync));
+
+	se = node;
 	sep->status = se->status;
 
 	if (se->status == BT_HCI_ERR_OP_CANCELLED_BY_HOST) {
@@ -6403,6 +6424,7 @@ static void le_big_sync_established(struct pdu_data *pdu,
 	struct node_rx_sync_iso *se;
 	struct lll_sync_iso *lll;
 	size_t evt_size;
+	void *node;
 
 	if (!(event_mask & BT_EVT_MASK_LE_META_EVENT) ||
 	    !(le_event_mask & BT_EVT_MASK_LE_BIG_SYNC_ESTABLISHED)) {
@@ -6417,7 +6439,13 @@ static void le_big_sync_established(struct pdu_data *pdu,
 	sep = meta_evt(buf, BT_HCI_EVT_LE_BIG_SYNC_ESTABLISHED, evt_size);
 	sep->big_handle = sys_cpu_to_le16(node_rx->hdr.handle);
 
-	se = (void *)pdu;
+	/* Check for pdu field being aligned before accessing ISO sync
+	 * established event.
+	 */
+	node = pdu;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_sync_iso));
+
+	se = node;
 	sep->status = se->status;
 	if (sep->status) {
 		return;
@@ -6612,9 +6640,19 @@ static void le_scan_req_received(struct pdu_data *pdu_data,
 static void le_conn_complete(struct pdu_data *pdu_data, uint16_t handle,
 			     struct net_buf *buf)
 {
-	struct node_rx_cc *cc = (void *)pdu_data;
 	struct bt_hci_evt_le_conn_complete *lecc;
-	uint8_t status = cc->status;
+	struct node_rx_cc *cc;
+	uint8_t status;
+	void *node;
+
+	/* Check for pdu field being aligned before accessing connection
+	 * complete event.
+	 */
+	node = pdu_data;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cc));
+
+	cc = node;
+	status = cc->status;
 
 #if defined(CONFIG_BT_CTLR_PRIVACY)
 	if (!status) {
@@ -6731,6 +6769,7 @@ static void le_conn_update_complete(struct pdu_data *pdu_data, uint16_t handle,
 {
 	struct bt_hci_evt_le_conn_update_complete *sep;
 	struct node_rx_cu *cu;
+	void *node;
 
 	if (!(event_mask & BT_EVT_MASK_LE_META_EVENT) ||
 	    !(le_event_mask & BT_EVT_MASK_LE_CONN_UPDATE_COMPLETE)) {
@@ -6739,7 +6778,13 @@ static void le_conn_update_complete(struct pdu_data *pdu_data, uint16_t handle,
 
 	sep = meta_evt(buf, BT_HCI_EVT_LE_CONN_UPDATE_COMPLETE, sizeof(*sep));
 
-	cu = (void *)pdu_data;
+	/* Check for pdu field being aligned before accessing connection
+	 * update complete event.
+	 */
+	node = pdu_data;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cu));
+
+	cu = node;
 	sep->status = cu->status;
 	sep->handle = sys_cpu_to_le16(handle);
 	sep->interval = sys_cpu_to_le16(cu->interval);
diff --git a/subsys/bluetooth/controller/ll_sw/ull_central.c b/subsys/bluetooth/controller/ll_sw/ull_central.c
index 15d0e81c510..dd34919395b 100644
--- a/subsys/bluetooth/controller/ll_sw/ull_central.c
+++ b/subsys/bluetooth/controller/ll_sw/ull_central.c
@@ -807,6 +807,7 @@ void ull_central_setup(struct node_rx_hdr *rx, struct node_rx_ftr *ftr,
 	struct ll_conn *conn;
 	memq_link_t *link;
 	uint8_t chan_sel;
+	void *node;
 
 	/* Get reference to Tx-ed CONNECT_IND PDU */
 	pdu_tx = (void *)((struct node_rx_pdu *)rx)->pdu;
@@ -820,8 +821,14 @@ void ull_central_setup(struct node_rx_hdr *rx, struct node_rx_ftr *ftr,
 	/* This is the chan sel bit from the received adv pdu */
 	chan_sel = pdu_tx->chan_sel;
 
+	/* Check for pdu field being aligned before populating connection
+	 * complete event.
+	 */
+	node = pdu_tx;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cc));
+
 	/* Populate the fields required for connection complete event */
-	cc = (void *)pdu_tx;
+	cc = node;
 	cc->status = 0U;
 	cc->role = 0U;
 
diff --git a/subsys/bluetooth/controller/ll_sw/ull_conn.c b/subsys/bluetooth/controller/ll_sw/ull_conn.c
index 8f91ad8d658..050fcd4fc4d 100644
--- a/subsys/bluetooth/controller/ll_sw/ull_conn.c
+++ b/subsys/bluetooth/controller/ll_sw/ull_conn.c
@@ -2852,6 +2852,7 @@ static inline void event_conn_upd_init(struct ll_conn *conn,
 
 	{
 		uint32_t retval;
+		void *win_offs;
 
 		/* calculate window offset that places the connection in the
 		 * next available slot after existing centrals.
@@ -2870,8 +2871,12 @@ static inline void event_conn_upd_init(struct ll_conn *conn,
 		}
 #endif /* CONFIG_BT_CTLR_XTAL_ADVANCED */
 
-		conn->llcp.conn_upd.pdu_win_offset = (uint16_t *)
-			&pdu_ctrl_tx->llctrl.conn_update_ind.win_offset;
+		win_offs = &pdu_ctrl_tx->llctrl.conn_update_ind.win_offset;
+		/* No need to check alignment here since the pointer that gets
+		 * stored is never derreferenced directly, only passed
+		 * to memcpy().
+		 */
+		conn->llcp.conn_upd.pdu_win_offset = win_offs;
 
 		mfy_sched_offset->fp = fp_mfy_select_or_use;
 		mfy_sched_offset->param = (void *)conn;
@@ -3737,6 +3742,7 @@ static inline void event_conn_param_req(struct ll_conn *conn,
 		static struct mayfly s_mfy_sched_offset = {0, 0, &s_link, NULL,
 			ull_sched_mfy_free_win_offset_calc};
 		uint32_t retval;
+		void *win_offs;
 
 		conn->llcp_conn_param.ticks_ref = ticks_at_expire;
 
@@ -3752,7 +3758,12 @@ static inline void event_conn_param_req(struct ll_conn *conn,
 		}
 #endif /* CONFIG_BT_CTLR_XTAL_ADVANCED */
 
-		conn->llcp_conn_param.pdu_win_offset0 = (uint16_t *)&p->offset0;
+		win_offs = &p->offset0;
+		/* No need to check alignment here since the pointer that gets
+		 * stored is never derreferenced directly, only passed
+		 * to memcpy().
+		 */
+		conn->llcp_conn_param.pdu_win_offset0 = win_offs;
 
 		s_mfy_sched_offset.param = (void *)conn;
 
@@ -5177,6 +5188,7 @@ static inline int reject_ind_conn_upd_recv(struct ll_conn *conn,
 	struct pdu_data_llctrl_reject_ext_ind *rej_ext_ind;
 	struct node_rx_cu *cu;
 	struct lll_conn *lll;
+	void *node;
 
 	/* Unsupported remote feature */
 	lll = &conn->lll;
@@ -5228,8 +5240,14 @@ static inline int reject_ind_conn_upd_recv(struct ll_conn *conn,
 	/* generate conn update complete event with error code */
 	rx->hdr.type = NODE_RX_TYPE_CONN_UPDATE;
 
+	/* check for pdu field being aligned before populating
+	 * connection update complete event.
+	 */
+	node = pdu_rx;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cu));
+
 	/* prepare connection update complete structure */
-	cu = (void *)pdu_rx;
+	cu = node;
 	cu->status = rej_ext_ind->error_code;
 	cu->interval = lll->interval;
 	cu->latency = lll->latency;
@@ -6006,6 +6024,7 @@ static uint8_t cis_req_recv(struct ll_conn *conn, memq_link_t *link,
 	struct node_rx_conn_iso_req *conn_iso_req;
 	uint16_t cis_handle;
 	uint8_t err;
+	void *node;
 
 	conn->llcp_cis.cig_id = req->cig_id;
 	conn->llcp_cis.framed = req->framed;
@@ -6028,7 +6047,13 @@ static uint8_t cis_req_recv(struct ll_conn *conn, memq_link_t *link,
 
 	(*rx)->hdr.type = NODE_RX_TYPE_CIS_REQUEST;
 
-	conn_iso_req = (void *)pdu;
+	/* check for pdu field being aligned before populating ISO
+	 * connection request event.
+	 */
+	node = pdu;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_conn_iso_req));
+
+	conn_iso_req = node;
 	conn_iso_req->cig_id = req->cig_id;
 	conn_iso_req->cis_id = req->cis_id;
 	conn_iso_req->cis_handle = sys_le16_to_cpu(cis_handle);
@@ -7014,6 +7039,7 @@ static inline int ctrl_rx(memq_link_t *link, struct node_rx_pdu **rx,
 			    PDU_DATA_LLCTRL_TYPE_CONN_PARAM_REQ)) {
 			struct lll_conn *lll = &conn->lll;
 			struct node_rx_cu *cu;
+			void *node;
 
 			/* Mark CPR as unsupported */
 			conn->llcp_conn_param.disabled = 1U;
@@ -7061,8 +7087,14 @@ static inline int ctrl_rx(memq_link_t *link, struct node_rx_pdu **rx,
 			/* generate conn upd complete event with error code */
 			(*rx)->hdr.type = NODE_RX_TYPE_CONN_UPDATE;
 
+			/* check for pdu field being aligned before populating
+			 * connection update complete event.
+			 */
+			node = pdu_rx;
+			LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cu));
+
 			/* prepare connection update complete structure */
-			cu = (void *)pdu_rx;
+			cu = node;
 			cu->status = BT_HCI_ERR_UNSUPP_REMOTE_FEATURE;
 			cu->interval = lll->interval;
 			cu->latency = lll->latency;
diff --git a/subsys/bluetooth/controller/ll_sw/ull_peripheral.c b/subsys/bluetooth/controller/ll_sw/ull_peripheral.c
index 9c3e84a5be0..33daeb74430 100644
--- a/subsys/bluetooth/controller/ll_sw/ull_peripheral.c
+++ b/subsys/bluetooth/controller/ll_sw/ull_peripheral.c
@@ -89,6 +89,7 @@ void ull_periph_setup(struct node_rx_hdr *rx, struct node_rx_ftr *ftr,
 	memq_link_t *link;
 	uint16_t timeout;
 	uint8_t chan_sel;
+	void *node;
 
 	adv = ((struct lll_adv *)ftr->param)->hdr.parent;
 	conn = lll->hdr.parent;
@@ -232,7 +233,14 @@ void ull_periph_setup(struct node_rx_hdr *rx, struct node_rx_ftr *ftr,
 		chan_sel = pdu_adv->chan_sel;
 	}
 
-	cc = (void *)pdu_adv;
+	/* Check for pdu field being aligned before populating connection
+	 * complete event.
+	 */
+	node = pdu_adv;
+	LL_ASSERT(IS_PTR_ALIGNED(node, struct node_rx_cc));
+
+	/* Populate the fields required for connection complete event */
+	cc = node;
 	cc->status = 0U;
 	cc->role = 1U;