diff --git a/subsys/bluetooth/controller/ll_sw/ull_conn.c b/subsys/bluetooth/controller/ll_sw/ull_conn.c
index 92d209d902a..28f39c8fe55 100644
--- a/subsys/bluetooth/controller/ll_sw/ull_conn.c
+++ b/subsys/bluetooth/controller/ll_sw/ull_conn.c
@@ -63,6 +63,7 @@ static void ticker_start_conn_op_cb(uint32_t status, void *param);
 
 static inline void disable(uint16_t handle);
 static void conn_cleanup(struct ll_conn *conn, uint8_t reason);
+static void tx_demux(void *param);
 static struct node_tx *tx_ull_dequeue(struct ll_conn *conn, struct node_tx *tx);
 static void tx_ull_flush(struct ll_conn *conn);
 static void tx_lll_flush(void *param);
@@ -236,6 +237,16 @@ int ll_tx_mem_enqueue(uint16_t handle, void *tx)
 
 	MFIFO_ENQUEUE(conn_tx, idx);
 
+	if (ull_ref_get(&conn->ull)) {
+		static memq_link_t link;
+		static struct mayfly mfy = {0, 0, &link, NULL, tx_demux};
+
+		mfy.param = conn;
+
+		mayfly_enqueue(TICKER_USER_ID_THREAD, TICKER_USER_ID_ULL_HIGH,
+			       0, &mfy);
+	}
+
 #if defined(CONFIG_BT_PERIPHERAL)
 	/* break slave latency */
 	if (conn->lll.role && conn->lll.latency_event &&
@@ -1694,6 +1705,13 @@ static void conn_cleanup(struct ll_conn *conn, uint8_t reason)
 	ull_conn_tx_demux(UINT8_MAX);
 }
 
+static void tx_demux(void *param)
+{
+	ull_conn_tx_demux(1);
+
+	ull_conn_tx_lll_enqueue(param, 1);
+}
+
 static struct node_tx *tx_ull_dequeue(struct ll_conn *conn, struct node_tx *tx)
 {
 	if (!conn->tx_ctrl && (conn->tx_head != conn->tx_data)) {
diff --git a/subsys/bluetooth/controller/ll_sw/ull_master.c b/subsys/bluetooth/controller/ll_sw/ull_master.c
index 38a487da5e2..937c04f16e2 100644
--- a/subsys/bluetooth/controller/ll_sw/ull_master.c
+++ b/subsys/bluetooth/controller/ll_sw/ull_master.c
@@ -752,11 +752,11 @@ void ull_master_ticker_cb(uint32_t ticks_at_expire, uint32_t remainder, uint16_t
 	ref = ull_ref_inc(&conn->ull);
 	LL_ASSERT(ref);
 
-	/* De-mux 1 tx node from FIFO */
-	ull_conn_tx_demux(1);
+	/* De-mux 2 tx node from FIFO, sufficient to be able to set MD bit */
+	ull_conn_tx_demux(2);
 
 	/* Enqueue towards LLL */
-	ull_conn_tx_lll_enqueue(conn, 1);
+	ull_conn_tx_lll_enqueue(conn, 2);
 
 	/* Append timing parameters */
 	p.ticks_at_expire = ticks_at_expire;