diff --git a/arch/arm/soc/nxp_kinetis/kwx/soc.h b/arch/arm/soc/nxp_kinetis/kwx/soc.h
index 37b34122034..ce6d492c3ce 100644
--- a/arch/arm/soc/nxp_kinetis/kwx/soc.h
+++ b/arch/arm/soc/nxp_kinetis/kwx/soc.h
@@ -29,7 +29,6 @@ extern "C" {
 #define IRQ_I2C1 9
 #define IRQ_SPI0 10
 #define IRQ_TSI0 11
-#define IRQ_LPUART0 12
 #define IRQ_TRNG0 13
 #define IRQ_CMT 14
 #define IRQ_ADC0 15
diff --git a/drivers/serial/uart_mcux_lpuart.c b/drivers/serial/uart_mcux_lpuart.c
index 02cbd0c941d..59b868fbd8e 100644
--- a/drivers/serial/uart_mcux_lpuart.c
+++ b/drivers/serial/uart_mcux_lpuart.c
@@ -297,10 +297,11 @@ DEVICE_AND_API_INIT(uart_0, CONFIG_UART_MCUX_LPUART_0_NAME,
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
 static void mcux_lpuart_config_func_0(struct device *dev)
 {
-	IRQ_CONNECT(IRQ_LPUART0, CONFIG_UART_MCUX_LPUART_0_IRQ_PRI,
+	IRQ_CONNECT(CONFIG_UART_MCUX_LPUART_0_IRQ,
+		    CONFIG_UART_MCUX_LPUART_0_IRQ_PRI,
 		    mcux_lpuart_isr, DEVICE_GET(uart_0), 0);
 
-	irq_enable(IRQ_LPUART0);
+	irq_enable(CONFIG_UART_MCUX_LPUART_0_IRQ);
 }
 #endif
 
diff --git a/dts/arm/frdm_kw41z.fixup b/dts/arm/frdm_kw41z.fixup
index ba21cc533f0..fcc541ce15d 100644
--- a/dts/arm/frdm_kw41z.fixup
+++ b/dts/arm/frdm_kw41z.fixup
@@ -1,6 +1,7 @@
 #define CONFIG_NUM_IRQ_PRIO_BITS		ARM_V6M_NVIC_E000E100_ARM_NUM_IRQ_PRIORITY_BITS
 
 #define CONFIG_UART_MCUX_LPUART_0_BAUD_RATE	NXP_KINETIS_LPUART_40054000_CURRENT_SPEED
+#define CONFIG_UART_MCUX_LPUART_0_IRQ		NXP_KINETIS_LPUART_40054000_IRQ_0
 #define CONFIG_UART_MCUX_LPUART_0_IRQ_PRI	NXP_KINETIS_LPUART_40054000_IRQ_0_PRIORITY
 #define CONFIG_UART_MCUX_LPUART_0_NAME		NXP_KINETIS_LPUART_40054000_LABEL
 
diff --git a/dts/arm/hexiwear_kw40z.fixup b/dts/arm/hexiwear_kw40z.fixup
index d8dd8c363f6..10e5121aba0 100644
--- a/dts/arm/hexiwear_kw40z.fixup
+++ b/dts/arm/hexiwear_kw40z.fixup
@@ -1,6 +1,7 @@
 #define CONFIG_NUM_IRQ_PRIO_BITS		ARM_V6M_NVIC_E000E100_ARM_NUM_IRQ_PRIORITY_BITS
 
 #define CONFIG_UART_MCUX_LPUART_0_BAUD_RATE	NXP_KINETIS_LPUART_40054000_CURRENT_SPEED
+#define CONFIG_UART_MCUX_LPUART_0_IRQ		NXP_KINETIS_LPUART_40054000_IRQ_0
 #define CONFIG_UART_MCUX_LPUART_0_IRQ_PRI	NXP_KINETIS_LPUART_40054000_IRQ_0_PRIORITY
 #define CONFIG_UART_MCUX_LPUART_0_NAME		NXP_KINETIS_LPUART_40054000_LABEL