diff --git a/drivers/serial/uart_nrfx_uarte.c b/drivers/serial/uart_nrfx_uarte.c
index bdafe6c7d4c..017efa6a2e5 100644
--- a/drivers/serial/uart_nrfx_uarte.c
+++ b/drivers/serial/uart_nrfx_uarte.c
@@ -937,11 +937,6 @@ static int uarte_nrfx_callback_set(const struct device *dev,
 	data->async->user_callback = callback;
 	data->async->user_data = user_data;
 
-#if defined(CONFIG_UART_EXCLUSIVE_API_CALLBACKS) && defined(UARTE_INTERRUPT_DRIVEN)
-	data->int_driven->cb = NULL;
-	data->int_driven->cb_data = NULL;
-#endif
-
 	return 0;
 }
 
@@ -1680,11 +1675,6 @@ static void uarte_nrfx_irq_callback_set(const struct device *dev,
 
 	data->int_driven->cb = cb;
 	data->int_driven->cb_data = cb_data;
-
-#if defined(UARTE_ANY_ASYNC) && defined(CONFIG_UART_EXCLUSIVE_API_CALLBACKS)
-	data->async->user_callback = NULL;
-	data->async->user_data = NULL;
-#endif
 }
 #endif /* UARTE_INTERRUPT_DRIVEN */