diff --git a/drivers/serial/uart_nrfx_uarte2.c b/drivers/serial/uart_nrfx_uarte2.c
index f052c1fb742..c76e2e05af3 100644
--- a/drivers/serial/uart_nrfx_uarte2.c
+++ b/drivers/serial/uart_nrfx_uarte2.c
@@ -385,6 +385,15 @@ static int api_tx(const struct device *dev, const uint8_t *buf, size_t len, int3
 	nrfx_err_t err;
 	bool hwfc;
 
+#if CONFIG_PM_DEVICE
+	enum pm_device_state state;
+
+	(void)pm_device_state_get(dev, &state);
+	if (state != PM_DEVICE_STATE_ACTIVE) {
+		return -ECANCELED;
+	}
+#endif
+
 #if CONFIG_UART_USE_RUNTIME_CONFIGURE
 	hwfc = data->uart_config.flow_ctrl == UART_CFG_FLOW_CTRL_RTS_CTS;
 #else
@@ -575,6 +584,15 @@ static void api_poll_out(const struct device *dev, unsigned char out_char)
 	const nrfx_uarte_t *nrfx_dev = get_nrfx_dev(dev);
 	nrfx_err_t err;
 
+#if CONFIG_PM_DEVICE
+	enum pm_device_state state;
+
+	(void)pm_device_state_get(dev, &state);
+	if (state != PM_DEVICE_STATE_ACTIVE) {
+		return;
+	}
+#endif
+
 	do {
 		/* When runtime PM is used we cannot use early return because then
 		 * we have no information when UART is actually done with the