diff --git a/drivers/serial/uart_mcux_lpuart.c b/drivers/serial/uart_mcux_lpuart.c
index c4bb661d324..e79cc1ff214 100644
--- a/drivers/serial/uart_mcux_lpuart.c
+++ b/drivers/serial/uart_mcux_lpuart.c
@@ -310,11 +310,19 @@ DEVICE_AND_API_INIT(uart_0, DT_UART_MCUX_LPUART_0_NAME,
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
 static void mcux_lpuart_config_func_0(struct device *dev)
 {
-	IRQ_CONNECT(DT_UART_MCUX_LPUART_0_IRQ,
-		    DT_UART_MCUX_LPUART_0_IRQ_PRI,
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_0_IRQ_0,
+		    DT_UART_MCUX_LPUART_0_IRQ_0_PRI,
 		    mcux_lpuart_isr, DEVICE_GET(uart_0), 0);
 
-	irq_enable(DT_UART_MCUX_LPUART_0_IRQ);
+	irq_enable(DT_UART_MCUX_LPUART_0_IRQ_0);
+
+#ifdef DT_UART_MCUX_LPUART_0_IRQ_1
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_0_IRQ_1,
+		    DT_UART_MCUX_LPUART_0_IRQ_1_PRI,
+		    mcux_lpuart_isr, DEVICE_GET(uart_0), 0);
+
+	irq_enable(DT_UART_MCUX_LPUART_0_IRQ_1);
+#endif /* DT_UART_MCUX_LPUART_0_IRQ_1 */
 }
 #endif
 
@@ -348,11 +356,19 @@ DEVICE_AND_API_INIT(uart_1, DT_UART_MCUX_LPUART_1_NAME,
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
 static void mcux_lpuart_config_func_1(struct device *dev)
 {
-	IRQ_CONNECT(DT_UART_MCUX_LPUART_1_IRQ,
-		    DT_UART_MCUX_LPUART_1_IRQ_PRI,
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_1_IRQ_0,
+		    DT_UART_MCUX_LPUART_1_IRQ_0_PRI,
 		    mcux_lpuart_isr, DEVICE_GET(uart_1), 0);
 
-	irq_enable(DT_UART_MCUX_LPUART_1_IRQ);
+	irq_enable(DT_UART_MCUX_LPUART_1_IRQ_0);
+
+#ifdef DT_UART_MCUX_LPUART_1_IRQ_1
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_1_IRQ_1,
+		    DT_UART_MCUX_LPUART_1_IRQ_1_PRI,
+		    mcux_lpuart_isr, DEVICE_GET(uart_1), 0);
+
+	irq_enable(DT_UART_MCUX_LPUART_1_IRQ_1);
+#endif /* DT_UART_MCUX_LPUART_1_IRQ_1 */
 }
 #endif
 
@@ -386,11 +402,19 @@ DEVICE_AND_API_INIT(uart_2, DT_UART_MCUX_LPUART_2_NAME,
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
 static void mcux_lpuart_config_func_2(struct device *dev)
 {
-	IRQ_CONNECT(DT_UART_MCUX_LPUART_2_IRQ,
-		    DT_UART_MCUX_LPUART_2_IRQ_PRI,
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_2_IRQ_0,
+		    DT_UART_MCUX_LPUART_2_IRQ_0_PRI,
 		    mcux_lpuart_isr, DEVICE_GET(uart_2), 0);
 
-	irq_enable(DT_UART_MCUX_LPUART_2_IRQ);
+	irq_enable(DT_UART_MCUX_LPUART_2_IRQ_0);
+
+#ifdef DT_UART_MCUX_LPUART_2_IRQ_1
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_2_IRQ_1,
+		    DT_UART_MCUX_LPUART_2_IRQ_1_PRI,
+		    mcux_lpuart_isr, DEVICE_GET(uart_2), 0);
+
+	irq_enable(DT_UART_MCUX_LPUART_2_IRQ_1);
+#endif /* DT_UART_MCUX_LPUART_2_IRQ_1 */
 }
 #endif
 
@@ -424,11 +448,19 @@ DEVICE_AND_API_INIT(uart_3, DT_UART_MCUX_LPUART_3_NAME,
 #ifdef CONFIG_UART_INTERRUPT_DRIVEN
 static void mcux_lpuart_config_func_3(struct device *dev)
 {
-	IRQ_CONNECT(DT_UART_MCUX_LPUART_3_IRQ,
-		    DT_UART_MCUX_LPUART_3_IRQ_PRI,
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_3_IRQ_0,
+		    DT_UART_MCUX_LPUART_3_IRQ_0_PRI,
 		    mcux_lpuart_isr, DEVICE_GET(uart_3), 0);
 
-	irq_enable(DT_UART_MCUX_LPUART_3_IRQ);
+	irq_enable(DT_UART_MCUX_LPUART_3_IRQ_0);
+
+#ifdef DT_UART_MCUX_LPUART_3_IRQ_1
+	IRQ_CONNECT(DT_UART_MCUX_LPUART_3_IRQ_1,
+		    DT_UART_MCUX_LPUART_3_IRQ_1_PRI,
+		    mcux_lpuart_isr, DEVICE_GET(uart_3), 0);
+
+	irq_enable(DT_UART_MCUX_LPUART_3_IRQ_1);
+#endif /* DT_UART_MCUX_LPUART_3_IRQ_1 */
 }
 #endif
 
diff --git a/soc/arm/nxp_imx/rt/dts_fixup.h b/soc/arm/nxp_imx/rt/dts_fixup.h
index 500f6648e5f..855e8ded0af 100644
--- a/soc/arm/nxp_imx/rt/dts_fixup.h
+++ b/soc/arm/nxp_imx/rt/dts_fixup.h
@@ -80,24 +80,24 @@
 
 #define DT_UART_MCUX_LPUART_1_BASE_ADDRESS	DT_NXP_KINETIS_LPUART_40184000_BASE_ADDRESS
 #define DT_UART_MCUX_LPUART_1_NAME		DT_NXP_KINETIS_LPUART_40184000_LABEL
-#define DT_UART_MCUX_LPUART_1_IRQ		DT_NXP_KINETIS_LPUART_40184000_IRQ_0
-#define DT_UART_MCUX_LPUART_1_IRQ_PRI		DT_NXP_KINETIS_LPUART_40184000_IRQ_0_PRIORITY
+#define DT_UART_MCUX_LPUART_1_IRQ_0		DT_NXP_KINETIS_LPUART_40184000_IRQ_0
+#define DT_UART_MCUX_LPUART_1_IRQ_0_PRI		DT_NXP_KINETIS_LPUART_40184000_IRQ_0_PRIORITY
 #define DT_UART_MCUX_LPUART_1_BAUD_RATE		DT_NXP_KINETIS_LPUART_40184000_CURRENT_SPEED
 #define DT_UART_MCUX_LPUART_1_CLOCK_NAME	DT_NXP_KINETIS_LPUART_40184000_CLOCK_CONTROLLER
 #define DT_UART_MCUX_LPUART_1_CLOCK_SUBSYS	DT_NXP_KINETIS_LPUART_40184000_CLOCK_NAME
 
 #define DT_UART_MCUX_LPUART_2_BASE_ADDRESS	DT_NXP_KINETIS_LPUART_40188000_BASE_ADDRESS
 #define DT_UART_MCUX_LPUART_2_NAME		DT_NXP_KINETIS_LPUART_40188000_LABEL
-#define DT_UART_MCUX_LPUART_2_IRQ		DT_NXP_KINETIS_LPUART_40188000_IRQ_0
-#define DT_UART_MCUX_LPUART_2_IRQ_PRI		DT_NXP_KINETIS_LPUART_40188000_IRQ_0_PRIORITY
+#define DT_UART_MCUX_LPUART_2_IRQ_0		DT_NXP_KINETIS_LPUART_40188000_IRQ_0
+#define DT_UART_MCUX_LPUART_2_IRQ_0_PRI		DT_NXP_KINETIS_LPUART_40188000_IRQ_0_PRIORITY
 #define DT_UART_MCUX_LPUART_2_BAUD_RATE		DT_NXP_KINETIS_LPUART_40188000_CURRENT_SPEED
 #define DT_UART_MCUX_LPUART_2_CLOCK_NAME	DT_NXP_KINETIS_LPUART_40188000_CLOCK_CONTROLLER
 #define DT_UART_MCUX_LPUART_2_CLOCK_SUBSYS	DT_NXP_KINETIS_LPUART_40188000_CLOCK_NAME
 
 #define DT_UART_MCUX_LPUART_3_BASE_ADDRESS	DT_NXP_KINETIS_LPUART_4018C000_BASE_ADDRESS
 #define DT_UART_MCUX_LPUART_3_NAME		DT_NXP_KINETIS_LPUART_4018C000_LABEL
-#define DT_UART_MCUX_LPUART_3_IRQ		DT_NXP_KINETIS_LPUART_4018C000_IRQ_0
-#define DT_UART_MCUX_LPUART_3_IRQ_PRI		DT_NXP_KINETIS_LPUART_4018C000_IRQ_0_PRIORITY
+#define DT_UART_MCUX_LPUART_3_IRQ_0		DT_NXP_KINETIS_LPUART_4018C000_IRQ_0
+#define DT_UART_MCUX_LPUART_3_IRQ_0_PRI		DT_NXP_KINETIS_LPUART_4018C000_IRQ_0_PRIORITY
 #define DT_UART_MCUX_LPUART_3_BAUD_RATE		DT_NXP_KINETIS_LPUART_4018C000_CURRENT_SPEED
 #define DT_UART_MCUX_LPUART_3_CLOCK_NAME	DT_NXP_KINETIS_LPUART_4018C000_CLOCK_CONTROLLER
 #define DT_UART_MCUX_LPUART_3_CLOCK_SUBSYS	DT_NXP_KINETIS_LPUART_4018C000_CLOCK_NAME
diff --git a/soc/arm/nxp_kinetis/kwx/dts_fixup.h b/soc/arm/nxp_kinetis/kwx/dts_fixup.h
index ccdfab35be9..208190a451a 100644
--- a/soc/arm/nxp_kinetis/kwx/dts_fixup.h
+++ b/soc/arm/nxp_kinetis/kwx/dts_fixup.h
@@ -118,8 +118,8 @@
 #define DT_NUM_IRQ_PRIO_BITS		DT_ARM_V6M_NVIC_E000E100_ARM_NUM_IRQ_PRIORITY_BITS
 
 #define DT_UART_MCUX_LPUART_0_BAUD_RATE	DT_NXP_KINETIS_LPUART_40054000_CURRENT_SPEED
-#define DT_UART_MCUX_LPUART_0_IRQ		DT_NXP_KINETIS_LPUART_40054000_IRQ_0
-#define DT_UART_MCUX_LPUART_0_IRQ_PRI	DT_NXP_KINETIS_LPUART_40054000_IRQ_0_PRIORITY
+#define DT_UART_MCUX_LPUART_0_IRQ_0		DT_NXP_KINETIS_LPUART_40054000_IRQ_0
+#define DT_UART_MCUX_LPUART_0_IRQ_0_PRI	DT_NXP_KINETIS_LPUART_40054000_IRQ_0_PRIORITY
 #define DT_UART_MCUX_LPUART_0_NAME		DT_NXP_KINETIS_LPUART_40054000_LABEL
 #define DT_UART_MCUX_LPUART_0_CLOCK_NAME	DT_NXP_KINETIS_LPUART_40054000_CLOCK_CONTROLLER
 #define DT_UART_MCUX_LPUART_0_CLOCK_SUBSYS	DT_NXP_KINETIS_LPUART_40054000_CLOCK_NAME