diff --git a/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c b/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
index b76fac86bcd..a9e8b3de7a9 100644
--- a/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
+++ b/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
@@ -18,6 +18,9 @@
 #define CAN121_SIZE	DT_REG_SIZE_BY_NAME(DT_NODELABEL(can121), message_ram) + \
 			DT_REG_SIZE_BY_NAME(DT_NODELABEL(can121), m_can)
 
+#define SOFTPERIPH_BASE	DT_REG_ADDR(DT_NODELABEL(softperiph_ram))
+#define SOFTPERIPH_SIZE	DT_REG_SIZE(DT_NODELABEL(softperiph_ram))
+
 static struct arm_mpu_region mpu_regions[] = {
 	MPU_REGION_ENTRY("FLASH_0",
 			 CONFIG_FLASH_BASE_ADDRESS,
@@ -40,6 +43,10 @@ static struct arm_mpu_region mpu_regions[] = {
 	MPU_REGION_ENTRY("CAN121_MCAN", CAN121_BASE,
 			 REGION_RAM_NOCACHE_ATTR(CAN121_BASE, CAN121_SIZE)),
 #endif
+#if DT_NODE_EXISTS(DT_NODELABEL(softperiph_ram))
+	MPU_REGION_ENTRY("SOFTPERIPH_RAM", SOFTPERIPH_BASE,
+			 REGION_RAM_NOCACHE_ATTR(SOFTPERIPH_BASE, SOFTPERIPH_SIZE)),
+#endif
 };
 
 const struct arm_mpu_config mpu_config = {