diff --git a/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c b/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
index a86161f3cbe..66659588411 100644
--- a/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
+++ b/soc/nordic/common/nrf54hx_nrf92x_mpu_regions.c
@@ -14,6 +14,10 @@
 #define CAN120_SIZE	DT_REG_SIZE_BY_NAME(DT_NODELABEL(can120), message_ram) + \
 			DT_REG_SIZE_BY_NAME(DT_NODELABEL(can120), m_can)
 
+#define CAN121_BASE	DT_REG_ADDR_BY_NAME(DT_NODELABEL(can121), message_ram)
+#define CAN121_SIZE	DT_REG_SIZE_BY_NAME(DT_NODELABEL(can121), message_ram) + \
+			DT_REG_SIZE_BY_NAME(DT_NODELABEL(can121), m_can)
+
 static struct arm_mpu_region mpu_regions[] = {
 	MPU_REGION_ENTRY("FLASH_0",
 			 CONFIG_FLASH_BASE_ADDRESS,
@@ -32,6 +36,10 @@ static struct arm_mpu_region mpu_regions[] = {
 	MPU_REGION_ENTRY("CAN120_MCAN", CAN120_BASE,
 			 REGION_RAM_NOCACHE_ATTR(CAN120_BASE, CAN120_SIZE)),
 #endif
+#if DT_NODE_HAS_STATUS(DT_NODELABEL(can121), okay)
+	MPU_REGION_ENTRY("CAN121_MCAN", CAN121_BASE,
+			 REGION_RAM_NOCACHE_ATTR(CAN121_BASE, CAN121_SIZE)),
+#endif
 };
 
 const struct arm_mpu_config mpu_config = {