diff --git a/drivers/clock_control/Kconfig.nrf b/drivers/clock_control/Kconfig.nrf
index 23670ccd5dd..ce9edc100cb 100644
--- a/drivers/clock_control/Kconfig.nrf
+++ b/drivers/clock_control/Kconfig.nrf
@@ -15,7 +15,6 @@ menuconfig CLOCK_CONTROL_NRF
 	depends on SOC_COMPATIBLE_NRF
 	depends on !CLOCK_CONTROL_NRF_FORCE_ALT
 	select NRFX_CLOCK
-	select NRFX_POWER
 	default y
 	help
 	  Enable support for the Nordic Semiconductor nRFxx series SoC clock
diff --git a/drivers/usb/device/Kconfig b/drivers/usb/device/Kconfig
index ac96409892c..22ba24fd8a8 100644
--- a/drivers/usb/device/Kconfig
+++ b/drivers/usb/device/Kconfig
@@ -53,8 +53,8 @@ menuconfig USB_NRFX
 	depends on HAS_HW_NRF_USBD
 	select USB_DEVICE_DRIVER
 	select NRFX_USBD
+	select NRFX_POWER
 	select USB_DEVICE_DISABLE_ZLP_EPIN_HANDLING
-	select NRFX_USBREG if SOC_SERIES_NRF53X
 	help
 	  nRF USB Device Controller Driver
 
diff --git a/drivers/usb/device/usb_dc_nrfx.c b/drivers/usb/device/usb_dc_nrfx.c
index 5a53d38c8be..638f875c4b7 100644
--- a/drivers/usb/device/usb_dc_nrfx.c
+++ b/drivers/usb/device/usb_dc_nrfx.c
@@ -1927,24 +1927,28 @@ int usb_dc_wakeup_request(void)
 
 static int usb_init(const struct device *arg)
 {
-
-#ifdef CONFIG_SOC_SERIES_NRF53X
-	#undef DT_DRV_COMPAT
-	#define DT_DRV_COMPAT nordic_nrf_clock
-
+#ifdef CONFIG_HAS_HW_NRF_USBREG
 	/* Use CLOCK/POWER priority for compatibility with other series where
 	 * USB events are handled by CLOCK interrupt handler.
 	 */
-	IRQ_CONNECT(USBREGULATOR_IRQn, DT_INST_IRQ(0, priority),
-		    nrfx_usbreg_irq_handler, 0, 0);
+	IRQ_CONNECT(USBREGULATOR_IRQn,
+		    DT_IRQ(DT_INST(0, nordic_nrf_clock), priority),
+		    nrfx_isr, nrfx_usbreg_irq_handler, 0);
 	irq_enable(USBREGULATOR_IRQn);
 #endif
 
-	static const nrfx_power_usbevt_config_t config = {
+	/* Use default configuration of the nrfx_power driver. */
+	static const nrfx_power_config_t power_config = { 0 };
+
+	static const nrfx_power_usbevt_config_t usbevt_config = {
 		.handler = usb_dc_power_event_handler
 	};
 
-	nrfx_power_usbevt_init(&config);
+	/* Ignore the return value, as NRFX_ERROR_ALREADY_INITIALIZED is not
+	 * a problem here.
+	 */
+	(void)nrfx_power_init(&power_config);
+	nrfx_power_usbevt_init(&usbevt_config);
 
 	return 0;
 }