diff --git a/samples/net/openthread/coprocessor/src/main.c b/samples/net/openthread/coprocessor/src/main.c
index 54bce0d130e..de0a7135906 100644
--- a/samples/net/openthread/coprocessor/src/main.c
+++ b/samples/net/openthread/coprocessor/src/main.c
@@ -9,42 +9,9 @@
 #include <logging/log.h>
 LOG_MODULE_REGISTER(ot_br, LOG_LEVEL_DBG);
 
-#include <zephyr.h>
-#include <usb/usb_device.h>
-#include <drivers/uart.h>
-
 #define APP_BANNER "***** OpenThread NCP on Zephyr %s *****"
 
 void main(void)
 {
-#if defined(CONFIG_OPENTHREAD_COPROCESSOR_SPINEL_ON_UART_ACM)
-	const struct device *dev;
-	uint32_t baudrate = 0U;
-	int ret;
-
-	dev = device_get_binding(
-		CONFIG_OPENTHREAD_COPROCESSOR_SPINEL_ON_UART_DEV_NAME);
-	if (!dev) {
-		LOG_ERR("UART device not found");
-		return;
-	}
-
-	ret = usb_enable(NULL);
-	if (ret != 0) {
-		LOG_ERR("Failed to enable USB");
-		return;
-	}
-
-	LOG_INF("Wait for host to settle");
-	k_sleep(K_SECONDS(1));
-
-	ret = uart_line_ctrl_get(dev, UART_LINE_CTRL_BAUD_RATE, &baudrate);
-	if (ret) {
-		LOG_WRN("Failed to get baudrate, ret code %d", ret);
-	} else {
-		LOG_INF("Baudrate detected: %d", baudrate);
-	}
-#endif /* CONFIG_OPENTHREAD_COPROCESSOR_SPINEL_ON_UART_ACM */
-
 	LOG_INF(APP_BANNER, CONFIG_NET_SAMPLE_APPLICATION_VERSION);
 }
diff --git a/subsys/net/lib/openthread/platform/uart.c b/subsys/net/lib/openthread/platform/uart.c
index a787d3832a7..85167a26e0a 100644
--- a/subsys/net/lib/openthread/platform/uart.c
+++ b/subsys/net/lib/openthread/platform/uart.c
@@ -170,6 +170,39 @@ otError otPlatUartEnable(void)
 	uart_irq_callback_user_data_set(ot_uart.dev,
 					uart_callback,
 					(void *)&ot_uart);
+
+#ifdef CONFIG_OPENTHREAD_COPROCESSOR_SPINEL_ON_UART_ACM
+	{
+		int ret;
+		uint32_t dtr = 0U;
+
+		ret = usb_enable(NULL);
+		if (ret != 0) {
+			LOG_ERR("Failed to enable USB");
+			return OT_ERROR_FAILED;
+		}
+
+		LOG_INF("Waiting for host to be ready to communicate");
+
+		/* Data Terminal Ready - check if host is ready to communicate */
+		while (!dtr) {
+			ret = uart_line_ctrl_get(ot_uart.dev,
+						 UART_LINE_CTRL_DTR, &dtr);
+			if (ret) {
+				LOG_ERR("Failed to get Data Terminal Ready line state: %d",
+					ret);
+				continue;
+			}
+			k_msleep(100);
+		}
+
+		/* Data Carrier Detect Modem - mark connection as established */
+		(void)uart_line_ctrl_set(ot_uart.dev, UART_LINE_CTRL_DCD, 1);
+		/* Data Set Ready - the NCP SoC is ready to communicate */
+		(void)uart_line_ctrl_set(ot_uart.dev, UART_LINE_CTRL_DSR, 1);
+	}
+#endif /* CONFIG_OPENTHREAD_COPROCESSOR_SPINEL_ON_UART_ACM */
+
 	uart_irq_rx_enable(ot_uart.dev);
 
 	return OT_ERROR_NONE;