diff --git a/subsys/ipc/rpmsg_multi_instance/rpmsg_multi_instance.c b/subsys/ipc/rpmsg_multi_instance/rpmsg_multi_instance.c
index f21f93d0971..82d00916a6b 100644
--- a/subsys/ipc/rpmsg_multi_instance/rpmsg_multi_instance.c
+++ b/subsys/ipc/rpmsg_multi_instance/rpmsg_multi_instance.c
@@ -267,6 +267,12 @@ int rpmsg_mi_ctx_init(struct rpmsg_mi_ctx *ctx, const struct rpmsg_mi_ctx_cfg *c
 	/* Register IPM callback. This cb executes when msg has come. */
 	ipm_register_callback(ctx->ipm_rx_handle, ipm_callback, ctx);
 
+	err = ipm_set_enabled(ctx->ipm_rx_handle, 1);
+	if (err != 0) {
+		LOG_ERR("Could not enable IPM interrupts and callbacks for RX");
+		return err;
+	}
+
 	ctx->vq[RPMSG_VQ_0] = virtqueue_allocate(vring_size);
 	if (!ctx->vq[RPMSG_VQ_0]) {
 		LOG_ERR("virtqueue_allocate failed to alloc vq[RPMSG_VQ_0]");
diff --git a/subsys/ipc/rpmsg_service/rpmsg_backend.c b/subsys/ipc/rpmsg_service/rpmsg_backend.c
index 07902811f80..3f1a7ed98cc 100644
--- a/subsys/ipc/rpmsg_service/rpmsg_backend.c
+++ b/subsys/ipc/rpmsg_service/rpmsg_backend.c
@@ -229,6 +229,13 @@ int rpmsg_backend_init(struct metal_io_region **io, struct virtio_device *vdev)
 	}
 
 	ipm_register_callback(ipm_rx_handle, ipm_callback, NULL);
+
+	err = ipm_set_enabled(ipm_rx_handle, 1);
+	if (err != 0) {
+		LOG_ERR("Could not enable IPM interrupts and callbacks for RX");
+		return err;
+	}
+
 #elif defined(CONFIG_RPMSG_SERVICE_SINGLE_IPM_SUPPORT)
 	ipm_handle = device_get_binding(CONFIG_RPMSG_SERVICE_IPM_NAME);