diff --git a/drivers/usb/device/usb_dc_nrfx.c b/drivers/usb/device/usb_dc_nrfx.c
index 4e15149ff4f..85cea536905 100644
--- a/drivers/usb/device/usb_dc_nrfx.c
+++ b/drivers/usb/device/usb_dc_nrfx.c
@@ -1235,6 +1235,45 @@ static inline void usbd_reinit(void)
 	}
 }
 
+/**
+ * @brief funciton to generate fake receive request for
+ * ISO OUT EP.
+ *
+ * ISO OUT endpoint does not generate irq by itself and reading
+ * from ISO OUT ep is sunchronized with SOF frame. For more details
+ * refer to Nordic usbd specification.
+ */
+static void usbd_sof_trigger_iso_read(void)
+{
+	struct usbd_event *ev;
+	struct nrf_usbd_ep_ctx *ep_ctx;
+
+	ep_ctx = endpoint_ctx(NRFX_USBD_EPOUT8);
+	if (!ep_ctx) {
+		LOG_ERR("There is no ISO ep");
+		return;
+	}
+
+	if (ep_ctx->cfg.en) {
+		/* Dissect receive request
+		 * if the iso OUT ep is enabled
+		 */
+		ep_ctx->read_pending = true;
+		ep_ctx->read_complete = true;
+		ev = usbd_evt_alloc();
+		if (!ev) {
+			LOG_ERR("Failed to alloc evt");
+			return;
+		}
+		ev->evt_type = USBD_EVT_EP;
+		ev->evt.ep_evt.evt_type = EP_EVT_RECV_REQ;
+		ev->evt.ep_evt.ep = ep_ctx;
+		usbd_evt_put(ev);
+		usbd_work_schedule();
+	} else {
+		LOG_DBG("Endpoint is not enabled");
+	}
+}
 
 /* Work handler */
 static void usbd_work_handler(struct k_work *item)
@@ -1273,6 +1312,8 @@ static void usbd_work_handler(struct k_work *item)
 			}
 			break;
 		case USBD_EVT_SOF:
+			usbd_sof_trigger_iso_read();
+
 			if (ctx->status_cb) {
 				ctx->status_cb(USB_DC_SOF, NULL);
 			}
diff --git a/subsys/usb/Kconfig b/subsys/usb/Kconfig
index 60a7d997191..1dc879b726c 100644
--- a/subsys/usb/Kconfig
+++ b/subsys/usb/Kconfig
@@ -72,6 +72,7 @@ config USB_NUMOF_EP_WRITE_RETRIES
 
 config USB_DEVICE_SOF
 	bool "Enable Start of Frame processing in events"
+	default y if (USB_DEVICE_AUDIO && NRFX_USBD)
 
 config USB_DEVICE_REMOTE_WAKEUP
 	bool "Enable support for remote wakeup"