diff --git a/boards/arm/nucleo_l552ze_q/CMakeLists.txt b/boards/arm/nucleo_l552ze_q/CMakeLists.txt
index 84009733da8..d170d283e99 100644
--- a/boards/arm/nucleo_l552ze_q/CMakeLists.txt
+++ b/boards/arm/nucleo_l552ze_q/CMakeLists.txt
@@ -1,5 +1,6 @@
 # SPDX-License-Identifier: Apache-2.0
 
+# Define the toolchain to be used (by eg CI)
 if(${ZEPHYR_TOOLCHAIN_VARIANT} STREQUAL "zephyr")
 	set(COMPILER_FULL_PATH ${ZEPHYR_SDK_INSTALL_DIR}/arm-zephyr-eabi/bin/arm-zephyr-eabi-gcc)
 elseif(${ZEPHYR_TOOLCHAIN_VARIANT} STREQUAL "gnuarmemb")
diff --git a/boards/arm/nucleo_l552ze_q/board.cmake b/boards/arm/nucleo_l552ze_q/board.cmake
index c1f04ce1bc6..fb1f2e43eaf 100644
--- a/boards/arm/nucleo_l552ze_q/board.cmake
+++ b/boards/arm/nucleo_l552ze_q/board.cmake
@@ -1,6 +1,10 @@
+# SPDX-License-Identifier: Apache-2.0
 if(CONFIG_BUILD_WITH_TFM)
   set(FLASH_BASE_ADDRESS_S 0x0C000000)
 
+  # Flash merged TF-M + Zephyr binary
+  set_property(TARGET runners_yaml_props_target PROPERTY hex_file "${CMAKE_BINARY_DIR}/tfm_merged.hex")
+
   if (CONFIG_HAS_FLASH_LOAD_OFFSET)
     MATH(EXPR TFM_HEX_BASE_ADDRESS_NS "${FLASH_BASE_ADDRESS_S}+${CONFIG_FLASH_LOAD_OFFSET}")
   else()
diff --git a/boards/arm/nucleo_l552ze_q/doc/nucleol552ze_q.rst b/boards/arm/nucleo_l552ze_q/doc/nucleol552ze_q.rst
index 13692195b0e..3a31ecfcf46 100644
--- a/boards/arm/nucleo_l552ze_q/doc/nucleol552ze_q.rst
+++ b/boards/arm/nucleo_l552ze_q/doc/nucleol552ze_q.rst
@@ -180,6 +180,44 @@ The default configuration can be found in the defconfig and dts files:
   - :zephyr_file:`boards/arm/nucleo_l552ze_q/nucleo_l552ze_q_ns_defconfig`
   - :zephyr_file:`boards/arm/nucleo_l552ze_q/nucleo_l552ze_q_ns.dts`
 
+Zephyr board options
+====================
+
+The STM32L552e is an SoC with Cortex-M33 architecture. Zephyr provides support
+for building for both Secure and Non-Secure firmware.
+
+The BOARD options are summarized below:
+
++----------------------+-----------------------------------------------+
+|   BOARD              | Description                                   |
++======================+===============================================+
+| nucleo_l552ze_q      | For building Secure (or Secure-only) firmware |
++----------------------+-----------------------------------------------+
+| nucleo_l552ze_q_ns   | For building Non-Secure firmware              |
++----------------------+-----------------------------------------------+
+
+Here are the instructions to build Zephyr with a non-secure configuration,
+using `tfm_ipc_` sample:
+
+   .. code-block:: bash
+
+      $ west build -b nucleo_l552ze_q_ns samples/tfm_integration/tfm_ipc/
+
+Once done, before flashing, you need to first run a generated script that
+will set platform option bytes config and erase platform (among others,
+option bit TZEN will be set).
+
+   .. code-block:: bash
+
+      $ ./build/tfm/regression.sh
+      $ west flash
+
+Please note that, after having run a TFM sample on the board, you will need to
+run `./build/tfm/regression.sh` once more to clean up the board from secure
+options and get back the platform back to a "normal" state and be able to run
+usual, non-TFM, binaries.
+Also note that, even then, TZEN will remain set, and you will need to use
+STM32CubeProgrammer_ to disable it fully, if required.
 
 Connections and IOs
 ===================
@@ -346,3 +384,6 @@ You can debug an application in the usual way.  Here is an example for the
 
 .. _STM32L552 reference manual:
    http://www.st.com/resource/en/reference_manual/DM00346336.pdf
+
+.. _STM32CubeProgrammer:
+   https://www.st.com/en/development-tools/stm32cubeprog.html
diff --git a/boards/arm/stm32l562e_dk/CMakeLists.txt b/boards/arm/stm32l562e_dk/CMakeLists.txt
index 4d67c648584..dde73804665 100644
--- a/boards/arm/stm32l562e_dk/CMakeLists.txt
+++ b/boards/arm/stm32l562e_dk/CMakeLists.txt
@@ -1,5 +1,6 @@
 # SPDX-License-Identifier: Apache-2.0
 
+# Define the toolchain to be used (by eg CI)
 if(${ZEPHYR_TOOLCHAIN_VARIANT} STREQUAL "zephyr")
   set(COMPILER_FULL_PATH ${ZEPHYR_SDK_INSTALL_DIR}/arm-zephyr-eabi/bin/arm-zephyr-eabi-gcc)
 elseif(${ZEPHYR_TOOLCHAIN_VARIANT} STREQUAL "gnuarmemb")
diff --git a/boards/arm/stm32l562e_dk/board.cmake b/boards/arm/stm32l562e_dk/board.cmake
index ddc46d4622c..08e5d44bdb8 100644
--- a/boards/arm/stm32l562e_dk/board.cmake
+++ b/boards/arm/stm32l562e_dk/board.cmake
@@ -1,6 +1,10 @@
+# SPDX-License-Identifier: Apache-2.0
 if(CONFIG_BUILD_WITH_TFM)
   set(TFM_FLASH_BASE_ADDRESS 0x0C000000)
 
+  # Flash merged TF-M + Zephyr binary
+  set_property(TARGET runners_yaml_props_target PROPERTY hex_file "${CMAKE_BINARY_DIR}/tfm_merged.hex")
+
   if (CONFIG_HAS_FLASH_LOAD_OFFSET)
     MATH(EXPR TFM_HEX_BASE_ADDRESS_NS "${TFM_FLASH_BASE_ADDRESS}+${CONFIG_FLASH_LOAD_OFFSET}")
   else()
diff --git a/boards/arm/stm32l562e_dk/doc/index.rst b/boards/arm/stm32l562e_dk/doc/index.rst
index 863f3be0627..7c4050f230b 100644
--- a/boards/arm/stm32l562e_dk/doc/index.rst
+++ b/boards/arm/stm32l562e_dk/doc/index.rst
@@ -206,6 +206,44 @@ The default configuration can be found in the defconfig and dts files:
   - :zephyr_file:`boards/arm/stm32l562e_dk/stm32l562e_dk_ns_defconfig`
   - :zephyr_file:`boards/arm/stm32l562e_dk/stm32l562e_dk_ns.dts`
 
+Zephyr board options
+====================
+
+The STM32L562e is an SoC with Cortex-M33 architecture. Zephyr provides support
+for building for both Secure and Non-Secure firmware.
+
+The BOARD options are summarized below:
+
++----------------------+-----------------------------------------------+
+|   BOARD              | Description                                   |
++======================+===============================================+
+| stm32l562e_dk        | For building Secure (or Secure-only) firmware |
++----------------------+-----------------------------------------------+
+| stm32l562e_dk_ns     | For building Non-Secure firmware              |
++----------------------+-----------------------------------------------+
+
+Here are the instructions to build Zephyr with a non-secure configuration,
+using `tfm_ipc_` sample:
+
+   .. code-block:: bash
+
+      $ west build -b stm32l562e_dk_ns samples/tfm_integration/tfm_ipc/
+
+Once done, before flashing, you need to first run a generated script that
+will set platform option bytes config and erase platform (among others,
+option bit TZEN will be set).
+
+   .. code-block:: bash
+
+      $ ./build/tfm/regression.sh
+      $ west flash
+
+Please note that, after having run a TFM sample on the board, you will need to
+run `./build/tfm/regression.sh` once more to clean up the board from secure
+options and get back the platform back to a "normal" state and be able to run
+usual, non-TFM, binaries.
+Also note that, even then, TZEN will remain set, and you will need to use
+STM32CubeProgrammer_ to disable it fully, if required.
 
 Connections and IOs
 ===================
@@ -344,3 +382,6 @@ You can debug an application in the usual way.  Here is an example for the
 
 .. _STM32L562 reference manual:
    http://www.st.com/resource/en/reference_manual/DM00346336.pdf
+
+.. _STM32CubeProgrammer:
+   https://www.st.com/en/development-tools/stm32cubeprog.html
diff --git a/samples/tfm_integration/tfm_ipc/README.rst b/samples/tfm_integration/tfm_ipc/README.rst
index c7f7f34ef0d..3f519b372e8 100644
--- a/samples/tfm_integration/tfm_ipc/README.rst
+++ b/samples/tfm_integration/tfm_ipc/README.rst
@@ -135,7 +135,7 @@ Run them in the following order to flash the board:
    .. code-block:: bash
 
       $ ./build/tfm/regression.sh
-      $ west flash --hex-file build/tfm_merged.hex
+      $ west flash
 
  .. note::
       Note that ``arm-none-eabi-gcc`` should be available in the PATH variable and that ``STM32_Programmer_CLI`` is required to run ``regression.sh`` (see https://www.st.com/en/development-tools/stm32cubeprog.html). If you are still having trouble running these scripts, check the Programming and Debugging section of the :ref:`nucleo_l552ze_q_board` or :ref:`stm32l562e_dk_board` documentation.