diff --git a/Kconfig.zephyr b/Kconfig.zephyr
index 1a4182d2d89..97d24c82958 100644
--- a/Kconfig.zephyr
+++ b/Kconfig.zephyr
@@ -436,13 +436,6 @@ config MAKEFILE_EXPORTS
 	  Generates a file with build information that can be read by
 	  third party Makefile-based build systems.
 
-config DEPRECATED_ZEPHYR_INT_TYPES
-	bool "Allow the use of the deprecated zephyr integer types"
-	help
-	  Allows the use of the deprecated Zephyr integer typedefs defined in
-	  Zephyr 2.3 and previous versions.  These types are:
-	  u8_t, u16_t, u32_t, u64_t, s8_t, s16_t, s32_t, and s64_t.
-
 endmenu
 endmenu
 
diff --git a/doc/releases/release-notes-2.6.rst b/doc/releases/release-notes-2.6.rst
index f7e1fbc56d5..1885fe4280c 100644
--- a/doc/releases/release-notes-2.6.rst
+++ b/doc/releases/release-notes-2.6.rst
@@ -57,6 +57,9 @@ Deprecated in this release
 ==========================
 
 Removed APIs in this release
+
+* Removed support for the old zephyr integer typedefs (u8_t, u16_t, etc...).
+
 ============================
 
 Stable API changes in this release
diff --git a/include/zephyr/types.h b/include/zephyr/types.h
index ada0cb84da0..c90eedd8136 100644
--- a/include/zephyr/types.h
+++ b/include/zephyr/types.h
@@ -14,20 +14,6 @@
 extern "C" {
 #endif
 
-#ifdef CONFIG_DEPRECATED_ZEPHYR_INT_TYPES
-
-typedef signed char         s8_t;
-typedef signed short        s16_t;
-typedef signed int          s32_t;
-typedef signed long long    s64_t;
-
-typedef unsigned char       u8_t;
-typedef unsigned short      u16_t;
-typedef unsigned int        u32_t;
-typedef unsigned long long  u64_t;
-
-#endif
-
 /* 32 bits on ILP32 builds, 64 bits on LP64 builts */
 typedef unsigned long       ulong_t;
 
diff --git a/tests/deprecated/inttype/CMakeLists.txt b/tests/deprecated/inttype/CMakeLists.txt
deleted file mode 100644
index 30b8735806e..00000000000
--- a/tests/deprecated/inttype/CMakeLists.txt
+++ /dev/null
@@ -1,8 +0,0 @@
-# SPDX-License-Identifier: Apache-2.0
-
-cmake_minimum_required(VERSION 3.13.1)
-
-find_package(Zephyr HINTS $ENV{ZEPHYR_BASE})
-project(test_inttypes)
-
-target_sources(app PRIVATE src/main.c)
diff --git a/tests/deprecated/inttype/prj.conf b/tests/deprecated/inttype/prj.conf
deleted file mode 100644
index a7bfcafe58d..00000000000
--- a/tests/deprecated/inttype/prj.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_DEPRECATED_ZEPHYR_INT_TYPES=y
diff --git a/tests/deprecated/inttype/src/main.c b/tests/deprecated/inttype/src/main.c
deleted file mode 100644
index 74bc769ede6..00000000000
--- a/tests/deprecated/inttype/src/main.c
+++ /dev/null
@@ -1,20 +0,0 @@
-/*
- * Copyright (c) 2020 Linaro
- *
- * SPDX-License-Identifier: Apache-2.0
- */
-
-#include <zephyr.h>
-
-void main(void)
-{
-	BUILD_ASSERT(sizeof(u8_t) == 1, "sizeof u8_t mismatch");
-	BUILD_ASSERT(sizeof(u16_t) == 2, "sizeof u16_t mismatch");
-	BUILD_ASSERT(sizeof(u32_t) == 4, "sizeof u32_t mismatch");
-	BUILD_ASSERT(sizeof(u64_t) == 8, "sizeof u64_t mismatch");
-
-	BUILD_ASSERT(sizeof(s8_t) == 1, "sizeof s8_t mismatch");
-	BUILD_ASSERT(sizeof(s16_t) == 2, "sizeof s16_t mismatch");
-	BUILD_ASSERT(sizeof(s32_t) == 4, "sizeof s32_t mismatch");
-	BUILD_ASSERT(sizeof(s64_t) == 8, "sizeof s64_t mismatch");
-}
diff --git a/tests/deprecated/inttype/testcase.yaml b/tests/deprecated/inttype/testcase.yaml
deleted file mode 100644
index 707f79127b3..00000000000
--- a/tests/deprecated/inttype/testcase.yaml
+++ /dev/null
@@ -1,4 +0,0 @@
-tests:
-  deprecated.inttypes:
-    build_only: true
-    tags: deprecated