diff --git a/drivers/serial/uart_stm32.c b/drivers/serial/uart_stm32.c
index 344f7d74161..87c5b049036 100644
--- a/drivers/serial/uart_stm32.c
+++ b/drivers/serial/uart_stm32.c
@@ -1694,6 +1694,10 @@ static int uart_stm32_init(const struct device *dev)
 		 * CONFIG_PM_DEVICE=y : Controlled by pm_device_wakeup_enable()
 		 */
 		LL_USART_EnableInStopMode(config->usart);
+		if (config->wakeup_line != STM32_EXTI_LINE_NONE) {
+			/* Prepare the WAKEUP with the expected EXTI line */
+			LL_EXTI_EnableIT_0_31(BIT(config->wakeup_line));
+		}
 	}
 #endif /* CONFIG_PM */
 
@@ -1843,8 +1847,11 @@ static void uart_stm32_irq_config_func_##index(const struct device *dev)	\
 #endif
 
 #ifdef CONFIG_PM
-#define STM32_UART_PM_WAKEUP(index)					\
-	.wakeup_source = DT_INST_PROP(index, wakeup_source),
+#define STM32_UART_PM_WAKEUP(index)						\
+	.wakeup_source = DT_INST_PROP(index, wakeup_source),			\
+	.wakeup_line = COND_CODE_1(DT_INST_NODE_HAS_PROP(index, wakeup_line),	\
+			(DT_INST_PROP(index, wakeup_line)),			\
+			(STM32_EXTI_LINE_NONE)),
 #else
 #define STM32_UART_PM_WAKEUP(index) /* Not used */
 #endif
diff --git a/drivers/serial/uart_stm32.h b/drivers/serial/uart_stm32.h
index cfa16204822..1d1f40b1d73 100644
--- a/drivers/serial/uart_stm32.h
+++ b/drivers/serial/uart_stm32.h
@@ -16,6 +16,8 @@
 
 #include <stm32_ll_usart.h>
 
+#define STM32_EXTI_LINE_NONE	0xFFFFFFFFU
+
 /* device config */
 struct uart_stm32_config {
 	/* USART instance */
@@ -44,6 +46,7 @@ struct uart_stm32_config {
 #if defined(CONFIG_PM)
 	/* Device defined as wake-up source */
 	bool wakeup_source;
+	uint32_t wakeup_line;
 #endif /* CONFIG_PM */
 };