diff --git a/drivers/bluetooth/hci/hci_silabs_efr32.c b/drivers/bluetooth/hci/hci_silabs_efr32.c
index b4eadcab9e2..7b7f880a016 100644
--- a/drivers/bluetooth/hci/hci_silabs_efr32.c
+++ b/drivers/bluetooth/hci/hci_silabs_efr32.c
@@ -55,20 +55,34 @@ void BTLE_LL_Process(uint32_t events);
 int16_t BTLE_LL_SetMaxPower(int16_t power);
 bool sli_pending_btctrl_events(void);
 
+#define RADIO_IRQN(name)     DT_IRQ_BY_NAME(DT_NODELABEL(radio), name, irq)
+#define RADIO_IRQ_PRIO(name) DT_IRQ_BY_NAME(DT_NODELABEL(radio), name, priority)
+
 void rail_isr_installer(void)
 {
-#ifdef CONFIG_SOC_SERIES_EFR32MG24
-	IRQ_CONNECT(SYNTH_IRQn, 0, SYNTH_IRQHandler, NULL, 0);
-#else
-	IRQ_CONNECT(RDMAILBOX_IRQn, 0, RDMAILBOX_IRQHandler, NULL, 0);
-#endif
-	IRQ_CONNECT(RAC_SEQ_IRQn, 0, RAC_SEQ_IRQHandler, NULL, 0);
-	IRQ_CONNECT(RAC_RSM_IRQn, 0, RAC_RSM_IRQHandler, NULL, 0);
-	IRQ_CONNECT(PROTIMER_IRQn, 0, PROTIMER_IRQHandler, NULL, 0);
-	IRQ_CONNECT(MODEM_IRQn, 0, MODEM_IRQHandler, NULL, 0);
-	IRQ_CONNECT(FRC_IRQn, 0, FRC_IRQHandler, NULL, 0);
-	IRQ_CONNECT(BUFC_IRQn, 0, BUFC_IRQHandler, NULL, 0);
-	IRQ_CONNECT(AGC_IRQn, 0, AGC_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(agc), RADIO_IRQ_PRIO(agc), AGC_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(bufc), RADIO_IRQ_PRIO(bufc), BUFC_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(frc_pri), RADIO_IRQ_PRIO(frc_pri), FRC_PRI_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(frc), RADIO_IRQ_PRIO(frc), FRC_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(modem), RADIO_IRQ_PRIO(modem), MODEM_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(protimer), RADIO_IRQ_PRIO(protimer), PROTIMER_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(rac_rsm), RADIO_IRQ_PRIO(rac_rsm), RAC_RSM_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(rac_seq), RADIO_IRQ_PRIO(rac_seq), RAC_SEQ_IRQHandler, NULL, 0);
+	IRQ_CONNECT(RADIO_IRQN(synth), RADIO_IRQ_PRIO(synth), SYNTH_IRQHandler, NULL, 0);
+
+	/* Depending on the chip family, either HOSTMAILBOX, RDMAILBOX or neither is present */
+	IF_ENABLED(DT_IRQ_HAS_NAME(DT_NODELABEL(radio), hostmailbox), ({
+		IRQ_CONNECT(RADIO_IRQN(hostmailbox),
+			    RADIO_IRQ_PRIO(hostmailbox),
+			    HOSTMAILBOX_IRQHandler,
+			    NULL, 0);
+	}));
+	IF_ENABLED(DT_IRQ_HAS_NAME(DT_NODELABEL(radio), rdmailbox), ({
+		IRQ_CONNECT(RADIO_IRQN(rdmailbox),
+			    RADIO_IRQ_PRIO(rdmailbox),
+			    RDMAILBOX_IRQHandler,
+			    NULL, 0);
+	}));
 }
 
 static bool slz_is_evt_discardable(const struct bt_hci_evt_hdr *hdr, const uint8_t *params,
@@ -275,7 +289,6 @@ static int slz_bt_open(const struct device *dev, bt_hci_recv_t recv)
 			K_PRIO_COOP(CONFIG_BT_DRIVER_RX_HIGH_PRIO), 0, K_NO_WAIT);
 	k_thread_name_set(&slz_rx_thread, "EFR32 HCI RX");
 
-	rail_isr_installer();
 	sl_rail_util_pa_init();
 
 	/* Initialize Controller features based on Kconfig values */
@@ -301,6 +314,9 @@ static int slz_bt_open(const struct device *dev, bt_hci_recv_t recv)
 		}
 	}
 
+	/* Set up interrupts after Controller init, because it will overwrite them. */
+	rail_isr_installer();
+
 	hci->recv = recv;
 
 	LOG_DBG("SiLabs BT HCI started");