diff --git a/drivers/serial/uart_ns16550.c b/drivers/serial/uart_ns16550.c
index ce1b56ba04d..6b599192de5 100644
--- a/drivers/serial/uart_ns16550.c
+++ b/drivers/serial/uart_ns16550.c
@@ -40,11 +40,15 @@
 
 #define INST_HAS_PCP_HELPER(inst) DT_INST_NODE_HAS_PROP(inst, pcp) ||
 #define INST_HAS_DLF_HELPER(inst) DT_INST_NODE_HAS_PROP(inst, dlf) ||
+#define INST_HAS_REG_SHIFT_HELPER(inst) \
+	DT_INST_NODE_HAS_PROP(inst, reg_shift) ||
 
 #define UART_NS16550_PCP_ENABLED \
 	(DT_INST_FOREACH_STATUS_OKAY(INST_HAS_PCP_HELPER) 0)
 #define UART_NS16550_DLF_ENABLED \
 	(DT_INST_FOREACH_STATUS_OKAY(INST_HAS_DLF_HELPER) 0)
+#define UART_NS16550_REG_INTERVAL_ENABLED \
+	(DT_INST_FOREACH_STATUS_OKAY(INST_HAS_REG_SHIFT_HELPER) 0)
 
 #if DT_ANY_INST_ON_BUS_STATUS_OKAY(pcie)
 BUILD_ASSERT(IS_ENABLED(CONFIG_PCIE), "NS16550(s) in DT need CONFIG_PCIE");
@@ -192,44 +196,32 @@ BUILD_ASSERT(IS_ENABLED(CONFIG_PCIE), "NS16550(s) in DT need CONFIG_PCIE");
 #define DEV_DATA(dev) \
 	((struct uart_ns16550_dev_data_t *)(dev)->data)
 
-#define THR(dev) (get_port(dev) + REG_THR * UART_REG_ADDR_INTERVAL)
-#define RDR(dev) (get_port(dev) + REG_RDR * UART_REG_ADDR_INTERVAL)
-#define BRDL(dev) \
-	(get_port(dev) + REG_BRDL * UART_REG_ADDR_INTERVAL)
-#define BRDH(dev) \
-	(get_port(dev) + REG_BRDH * UART_REG_ADDR_INTERVAL)
-#define IER(dev) (get_port(dev) + REG_IER * UART_REG_ADDR_INTERVAL)
-#define IIR(dev) (get_port(dev) + REG_IIR * UART_REG_ADDR_INTERVAL)
-#define FCR(dev) (get_port(dev) + REG_FCR * UART_REG_ADDR_INTERVAL)
-#define LCR(dev) (get_port(dev) + REG_LCR * UART_REG_ADDR_INTERVAL)
-#define MDC(dev) (get_port(dev) + REG_MDC * UART_REG_ADDR_INTERVAL)
-#define LSR(dev) (get_port(dev) + REG_LSR * UART_REG_ADDR_INTERVAL)
-#define MSR(dev) (get_port(dev) + REG_MSR * UART_REG_ADDR_INTERVAL)
+#define THR(dev) (get_port(dev) + REG_THR * reg_interval(dev))
+#define RDR(dev) (get_port(dev) + REG_RDR * reg_interval(dev))
+#define BRDL(dev) (get_port(dev) + REG_BRDL * reg_interval(dev))
+#define BRDH(dev) (get_port(dev) + REG_BRDH * reg_interval(dev))
+#define IER(dev) (get_port(dev) + REG_IER * reg_interval(dev))
+#define IIR(dev) (get_port(dev) + REG_IIR * reg_interval(dev))
+#define FCR(dev) (get_port(dev) + REG_FCR * reg_interval(dev))
+#define LCR(dev) (get_port(dev) + REG_LCR * reg_interval(dev))
+#define MDC(dev) (get_port(dev) + REG_MDC * reg_interval(dev))
+#define LSR(dev) (get_port(dev) + REG_LSR * reg_interval(dev))
+#define MSR(dev) (get_port(dev) + REG_MSR * reg_interval(dev))
 #define DLF(dev) (get_port(dev) + REG_DLF)
 #define PCP(dev) (get_port(dev) + REG_PCP)
 
 #define IIRC(dev) (DEV_DATA(dev)->iir_cache)
 
-#if DT_INST_NODE_HAS_PROP(0, reg_shift)
-#define UART_REG_ADDR_INTERVAL (1<<DT_INST_PROP(0, reg_shift))
-#endif
-
 #ifdef UART_NS16550_ACCESS_IOPORT
 #define INBYTE(x) sys_in8(x)
 #define INWORD(x) sys_in32(x)
 #define OUTBYTE(x, d) sys_out8(d, x)
 #define OUTWORD(x, d) sys_out32(d, x)
-#ifndef UART_REG_ADDR_INTERVAL
-#define UART_REG_ADDR_INTERVAL 1 /* address diff of adjacent regs. */
-#endif /* UART_REG_ADDR_INTERVAL */
 #else
 #define INBYTE(x) sys_read8(x)
 #define INWORD(x) sys_read32(x)
 #define OUTBYTE(x, d) sys_write8(d, x)
 #define OUTWORD(x, d) sys_write32(d, x)
-#ifndef UART_REG_ADDR_INTERVAL
-#define UART_REG_ADDR_INTERVAL 4 /* address diff of adjacent regs. */
-#endif
 #endif /* UART_NS16550_ACCESS_IOPORT */
 
 #ifdef CONFIG_UART_NS16550_ACCESS_WORD_ONLY
@@ -253,6 +245,9 @@ struct uart_ns16550_device_config {
 #if UART_NS16550_PCP_ENABLED
 	uint32_t pcp;
 #endif
+#if UART_NS16550_REG_INTERVAL_ENABLED
+	uint8_t reg_interval;
+#endif
 #if DT_ANY_INST_ON_BUS_STATUS_OKAY(pcie)
 	bool pcie;
 	pcie_bdf_t pcie_bdf;
@@ -279,6 +274,27 @@ struct uart_ns16550_dev_data_t {
 #endif
 };
 
+#if defined(UART_REG_ADDR_INTERVAL)
+#define DEFAULT_REG_INTERVAL UART_REG_ADDR_INTERVAL
+#elif defined(UART_NS16550_ACCESS_IOPORT)
+#define DEFAULT_REG_INTERVAL 1
+#else
+#define DEFAULT_REG_INTERVAL 4
+#endif
+
+#if UART_NS16550_REG_INTERVAL_ENABLED
+static inline uint8_t reg_interval(const struct device *dev)
+{
+	if (DEV_CFG(dev)->reg_interval) {
+		return DEV_CFG(dev)->reg_interval;
+	}
+
+	return DEFAULT_REG_INTERVAL;
+}
+#else
+#define reg_interval(dev) DEFAULT_REG_INTERVAL
+#endif
+
 static const struct uart_driver_api uart_ns16550_driver_api;
 
 static inline uintptr_t get_port(const struct device *dev)
diff --git a/drivers/serial/uart_ns16550_port_x.h b/drivers/serial/uart_ns16550_port_x.h
index a9940f67644..dfc09dd168d 100644
--- a/drivers/serial/uart_ns16550_port_x.h
+++ b/drivers/serial/uart_ns16550_port_x.h
@@ -29,6 +29,10 @@ static const struct uart_ns16550_device_config uart_ns16550_dev_cfg_@NUM@ = {
 	.pcp = DT_INST_PROP(@NUM@, pcp),
 #endif
 
+#if DT_INST_NODE_HAS_PROP(@NUM@, reg_shift)
+	.reg_interval = (1 <<  DT_INST_PROP(@NUM@, reg_shift))
+#endif
+
 #if DT_INST_ON_BUS(@NUM@, pcie)
 	.pcie = true,
 	.pcie_bdf = DT_INST_REG_ADDR(@NUM@),