diff --git a/drivers/i2c/Kconfig.nrfx b/drivers/i2c/Kconfig.nrfx
index 8fc88aad54e..987389c9992 100644
--- a/drivers/i2c/Kconfig.nrfx
+++ b/drivers/i2c/Kconfig.nrfx
@@ -9,8 +9,6 @@ menuconfig I2C_NRFX
 	depends on SOC_FAMILY_NRF
 	help
 	  Enable support for nrfx TWI drivers for nRF MCU series.
-	  Peripherals with the same instance ID cannot be used together,
-	  e.g. I2C_0 and SPI_0. You may need to disable SPI_0 or SPI_1.
 
 if I2C_NRFX
 
@@ -18,96 +16,48 @@ if I2C_NRFX
 DT_COMPAT_NORDIC_NRF_TWI  := nordic,nrf-twi
 DT_COMPAT_NORDIC_NRF_TWIM := nordic,nrf-twim
 
-# In most Nordic SoCs, SPI and TWI peripherals with the same instance
-# number share certain resources and therefore cannot be used at the
-# same time (in nRF91 and nRF53 Series this limitation concerns UART
-# peripherals as well). In nRF52810 though, there are only single
-# instances of these peripherals and they are arranged in a different
-# way, so this limitation does not apply.
-if I2C_0 && (SOC_NRF52810 || \
-	(!SPI_0 && !(SOC_SERIES_NRF91X && UART_0_NRF_UARTE)) || \
-	(!SPI_0 && !(SOC_SERIES_NRF53X && UART_0_NRF_UARTE)))
-
 config I2C_0_NRF_TWI
 	def_bool $(dt_nodelabel_has_compat,i2c0,$(DT_COMPAT_NORDIC_NRF_TWI))
-	depends on HAS_HW_NRF_TWI0
 	select NRFX_TWI0
 	help
 	  Enable nRF TWI Master without EasyDMA on port 0.
 
 config I2C_0_NRF_TWIM
 	def_bool $(dt_nodelabel_has_compat,i2c0,$(DT_COMPAT_NORDIC_NRF_TWIM))
-	depends on HAS_HW_NRF_TWIM0
 	select NRFX_TWIM0
 	help
 	  Enable nRF TWI Master with EasyDMA on port 0.
 	  This peripheral accepts transfers from RAM only,
 	  if provided buffer is placed in flash, transfer will fail.
 
-endif # I2C_0 && (SOC_NRF52810 || ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals
-# as well).
-if I2C_1 && !SPI_1 && \
-	!(SOC_SERIES_NRF91X && UART_1_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_1_NRF_UARTE)
-
 config I2C_1_NRF_TWI
 	def_bool $(dt_nodelabel_has_compat,i2c1,$(DT_COMPAT_NORDIC_NRF_TWI))
-	depends on HAS_HW_NRF_TWI1
 	select NRFX_TWI1
 	help
 	  Enable nRF TWI Master without EasyDMA on port 1.
 
 config I2C_1_NRF_TWIM
 	def_bool $(dt_nodelabel_has_compat,i2c1,$(DT_COMPAT_NORDIC_NRF_TWIM))
-	depends on HAS_HW_NRF_TWIM1
 	select NRFX_TWIM1
 	help
 	  Enable nRF TWI Master with EasyDMA on port 1.
 	  This peripheral accepts transfers from RAM only,
 	  if provided buffer is placed in flash, transfer will fail.
 
-endif # I2C_1 && !SPI_1 && ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals
-# as well).
-if I2C_2 && !SPI_2 && \
-	!(SOC_SERIES_NRF91X && UART_2_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_2_NRF_UARTE)
-
 config I2C_2_NRF_TWIM
 	def_bool $(dt_nodelabel_has_compat,i2c2,$(DT_COMPAT_NORDIC_NRF_TWIM))
-	depends on HAS_HW_NRF_TWIM2
 	select NRFX_TWIM2
 	help
 	  Enable nRF TWI Master with EasyDMA on port 2.
 	  This peripheral accepts transfers from RAM only,
 	  if provided buffer is placed in flash, transfer will fail.
 
-endif # I2C_2 && !SPI_2 && ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals
-# as well).
-if I2C_3 && !SPI_3 && \
-	!(SOC_SERIES_NRF91X && UART_3_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_3_NRF_UARTE)
-
 config I2C_3_NRF_TWIM
 	def_bool $(dt_nodelabel_has_compat,i2c3,$(DT_COMPAT_NORDIC_NRF_TWIM))
-	depends on HAS_HW_NRF_TWIM3
 	select NRFX_TWIM3
 	help
 	  Enable nRF TWI Master with EasyDMA on port 3.
 	  This peripheral accepts transfers from RAM only,
 	  if provided buffer is placed in flash, transfer will fail.
 
-endif # I2C_3 && !SPI_3 && ...
-
 endif # I2C_NRFX
diff --git a/drivers/serial/Kconfig.nrfx b/drivers/serial/Kconfig.nrfx
index f5e0e51e716..6b95e944d2f 100644
--- a/drivers/serial/Kconfig.nrfx
+++ b/drivers/serial/Kconfig.nrfx
@@ -24,17 +24,12 @@ DT_COMPAT_NORDIC_NRF_UARTE := nordic,nrf-uarte
 # ----------------- port 0 -----------------
 config UART_0_NRF_UART
 	def_bool $(dt_nodelabel_has_compat,uart0,$(DT_COMPAT_NORDIC_NRF_UART))
-	depends on HAS_HW_NRF_UART0
 	select NRF_UART_PERIPHERAL
 	help
 	  Enable nRF UART without EasyDMA on port 0.
 
 config UART_0_NRF_UARTE
 	def_bool $(dt_nodelabel_has_compat,uart0,$(DT_COMPAT_NORDIC_NRF_UARTE))
-	# In nRF91 and nRF53 Series SoCs, UART peripherals share certain resources with
-	# SPI and TWI peripherals having the same instance number, and therefore
-	# these cannot be used simultaneously.
-	depends on HAS_HW_NRF_UARTE0 && !((SOC_SERIES_NRF91X || SOC_SERIES_NRF53X) && (SPI_0 || I2C_0))
 	select NRF_UARTE_PERIPHERAL
 	help
 	  Enable nRF UART with EasyDMA on port 0.
@@ -104,10 +99,6 @@ endif # UART_0_NRF_UART || UART_0_NRF_UARTE
 # ----------------- port 1 -----------------
 config UART_1_NRF_UARTE
 	def_bool $(dt_nodelabel_has_compat,uart1,$(DT_COMPAT_NORDIC_NRF_UARTE))
-	# In nRF91 and nRF53 Series SoCs, UART peripherals share certain resources with
-	# SPI and TWI peripherals having the same instance number, and therefore
-	# these cannot be used simultaneously.
-	depends on HAS_HW_NRF_UARTE1 && !((SOC_SERIES_NRF91X || SOC_SERIES_NRF53X) && (SPI_1 || I2C_1))
 	select NRF_UARTE_PERIPHERAL
 	help
 	  Enable nRF UART with EasyDMA on port 1.
@@ -176,10 +167,6 @@ endif # UART_1_NRF_UARTE
 # ----------------- port 2 -----------------
 config UART_2_NRF_UARTE
 	def_bool $(dt_nodelabel_has_compat,uart2,$(DT_COMPAT_NORDIC_NRF_UARTE))
-	# In nRF91 and nRF53 Series SoCs, UART peripherals share certain resources with
-	# SPI and TWI peripherals having the same instance number, and therefore
-	# these cannot be used simultaneously.
-	depends on HAS_HW_NRF_UARTE2 && !((SOC_SERIES_NRF91X || SOC_SERIES_NRF53X) && (SPI_2 || I2C_2))
 	select NRF_UARTE_PERIPHERAL
 	help
 	  Enable nRF UART with EasyDMA on port 2.
@@ -247,10 +234,6 @@ endif # UART_2_NRF_UARTE
 # ----------------- port 3 -----------------
 config UART_3_NRF_UARTE
 	def_bool $(dt_nodelabel_has_compat,uart3,$(DT_COMPAT_NORDIC_NRF_UARTE))
-	# In nRF91 and nRF53 Series SoCs, UART peripherals share certain resources with
-	# SPI and TWI peripherals having the same instance number, and therefore
-	# these cannot be used simultaneously.
-	depends on HAS_HW_NRF_UARTE3 && !((SOC_SERIES_NRF91X || SOC_SERIES_NRF53X) && (SPI_3 || I2C_3))
 	select NRF_UARTE_PERIPHERAL
 	help
 	  Enable nRF UART with EasyDMA on port 3.
diff --git a/drivers/spi/Kconfig.nrfx b/drivers/spi/Kconfig.nrfx
index 93c22ecdb71..3f73b1d9fb2 100644
--- a/drivers/spi/Kconfig.nrfx
+++ b/drivers/spi/Kconfig.nrfx
@@ -7,8 +7,6 @@ menuconfig SPI_NRFX
 	depends on SOC_FAMILY_NRF
 	help
 	  Enable support for nrfx SPI drivers for nRF MCU series.
-	  Peripherals with the same instance ID cannot be used together,
-	  e.g. SPI_0 and I2C_0. You may need to disable I2C_0 or I2C_1.
 
 if SPI_NRFX
 
@@ -30,18 +28,8 @@ DT_COMPAT_NORDIC_NRF_SPI  := nordic,nrf-spi
 DT_COMPAT_NORDIC_NRF_SPIM := nordic,nrf-spim
 DT_COMPAT_NORDIC_NRF_SPIS := nordic,nrf-spis
 
-# In most Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals as well).
-# In nRF52810 though, there are only single instances of these peripherals
-# and they are arranged in a different way, so this limitation does not apply.
-if SPI_0 && (SOC_NRF52810 || \
-	(!I2C_0 && !(SOC_SERIES_NRF91X && UART_0_NRF_UARTE)) ||\
-	(!I2C_0 && !(SOC_SERIES_NRF53X && UART_0_NRF_UARTE)))
-
 config SPI_0_NRF_SPI
 	def_bool $(dt_nodelabel_has_compat,spi0,$(DT_COMPAT_NORDIC_NRF_SPI))
-	depends on HAS_HW_NRF_SPI0
 	select NRFX_SPI0
 	help
 	  Enable nRF SPI Master without EasyDMA on port 0.
@@ -51,14 +39,13 @@ config SPI_0_NRF_SPIM
 	# This driver is not available for nRF52832 because of Product Anomaly 58
 	# (SPIM: An additional byte is clocked out when RXD.MAXCNT == 1 and TXD.MAXCNT <= 1)
 	# Allow the 'EasyDMA' driver only if this automatic safety-disable is overridden
-	depends on HAS_HW_NRF_SPIM0 && (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
+	depends on (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
 	select NRFX_SPIM0
 	help
 	  Enable nRF SPI Master with EasyDMA on port 0.
 
 config SPI_0_NRF_SPIS
 	def_bool $(dt_nodelabel_has_compat,spi0,$(DT_COMPAT_NORDIC_NRF_SPIS))
-	depends on HAS_HW_NRF_SPIS0
 	depends on SPI_SLAVE
 	select NRFX_SPIS0
 	help
@@ -75,18 +62,8 @@ config SPI_0_NRF_ORC
 	  Over-read character. Character clocked out after an over-read
 	  of the transmit buffer.
 
-endif # SPI_0 && (SOC_NRF52810 || ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals as well).
-if SPI_1 && !I2C_1 && \
-	!(SOC_SERIES_NRF91X && UART_1_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_1_NRF_UARTE)
-
 config SPI_1_NRF_SPI
 	def_bool $(dt_nodelabel_has_compat,spi1,$(DT_COMPAT_NORDIC_NRF_SPI))
-	depends on HAS_HW_NRF_SPI1
 	select NRFX_SPI1
 	help
 	  Enable nRF SPI Master without EasyDMA on port 1.
@@ -96,14 +73,13 @@ config SPI_1_NRF_SPIM
 	# This driver is not available for nRF52832 because of Product Anomaly 58
 	# (SPIM: An additional byte is clocked out when RXD.MAXCNT == 1 and TXD.MAXCNT <= 1)
 	# Allow the 'EasyDMA' driver only if this automatic safety-disable is overridden
-	depends on HAS_HW_NRF_SPIM1 && (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
+	depends on (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
 	select NRFX_SPIM1
 	help
 	  Enable nRF SPI Master with EasyDMA on port 1.
 
 config SPI_1_NRF_SPIS
 	def_bool $(dt_nodelabel_has_compat,spi1,$(DT_COMPAT_NORDIC_NRF_SPIS))
-	depends on HAS_HW_NRF_SPIS1
 	depends on SPI_SLAVE
 	select NRFX_SPIS1
 	help
@@ -120,18 +96,8 @@ config SPI_1_NRF_ORC
 	  Over-read character. Character clocked out after an over-read
 	  of the transmit buffer.
 
-endif # SPI_1 && !I2C_1 && !(SOC_SERIES_NRF91X && UART_1_NRF_UARTE) && ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals as well).
-if SPI_2 && !I2C_2 && \
-	!(SOC_SERIES_NRF91X && UART_2_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_2_NRF_UARTE)
-
 config SPI_2_NRF_SPI
 	def_bool $(dt_nodelabel_has_compat,spi2,$(DT_COMPAT_NORDIC_NRF_SPI))
-	depends on HAS_HW_NRF_SPI2
 	select NRFX_SPI2
 	help
 	  Enable nRF SPI Master without EasyDMA on port 2.
@@ -141,14 +107,13 @@ config SPI_2_NRF_SPIM
 	# This driver is not available for nRF52832 because of Product Anomaly 58
 	# (SPIM: An additional byte is clocked out when RXD.MAXCNT == 1 and TXD.MAXCNT <= 1)
 	# Allow the 'EasyDMA' driver only if this automatic safety-disable is overridden
-	depends on HAS_HW_NRF_SPIM2 && (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
+	depends on (!SOC_NRF52832 || SOC_NRF52832_ALLOW_SPIM_DESPITE_PAN_58)
 	select NRFX_SPIM2
 	help
 	  Enable nRF SPI Master with EasyDMA on port 2.
 
 config SPI_2_NRF_SPIS
 	def_bool $(dt_nodelabel_has_compat,spi2,$(DT_COMPAT_NORDIC_NRF_SPIS))
-	depends on HAS_HW_NRF_SPIS2
 	depends on SPI_SLAVE
 	select NRFX_SPIS2
 	help
@@ -165,25 +130,14 @@ config SPI_2_NRF_ORC
 	  Over-read character. Character clocked out after an over-read
 	  of the transmit buffer.
 
-endif # SPI_2 && !I2C_2 && !(SOC_SERIES_NRF91X && UART_2_NRF_UARTE) && ...
-
-# In Nordic SoCs, SPI and TWI peripherals with the same instance number
-# share certain resources and therefore cannot be used at the same time
-# (in nRF91 and nRF53 Series this limitation concerns UART peripherals as well).
-if SPI_3 && !I2C_3 && \
-	!(SOC_SERIES_NRF91X && UART_3_NRF_UARTE) && \
-	!(SOC_SERIES_NRF53X && UART_3_NRF_UARTE)
-
 config SPI_3_NRF_SPIM
 	def_bool $(dt_nodelabel_has_compat,spi3,$(DT_COMPAT_NORDIC_NRF_SPIM))
-	depends on HAS_HW_NRF_SPIM3
 	select NRFX_SPIM3
 	help
 	  Enable nRF SPI Master with EasyDMA on port 3.
 
 config SPI_3_NRF_SPIS
 	def_bool $(dt_nodelabel_has_compat,spi3,$(DT_COMPAT_NORDIC_NRF_SPIS))
-	depends on HAS_HW_NRF_SPIS3
 	depends on SPI_SLAVE
 	select NRFX_SPIS3
 	help
@@ -210,13 +164,8 @@ config SPI_3_NRF_RX_DELAY
 	  edge of SCK (leading or trailing, depending on the CPHA setting used)
 	  until the input serial data on MISO is actually sampled.
 
-endif # SPI_3 && !I2C_3 && !(SOC_SERIES_NRF91X && UART_3_NRF_UARTE) && ...
-
-if SPI_4
-
 config SPI_4_NRF_SPIM
 	def_bool $(dt_nodelabel_has_compat,spi4,$(DT_COMPAT_NORDIC_NRF_SPIM))
-	depends on HAS_HW_NRF_SPIM4
 	select NRFX_SPIM4
 	help
 	  Enable nRF SPI Master with EasyDMA on port 4.
@@ -240,8 +189,6 @@ config SPI_4_NRF_RX_DELAY
 	  edge of SCK (leading or trailing, depending on the CPHA setting used)
 	  until the input serial data on MISO is actually sampled.
 
-endif # SPI_4
-
 config SPI_NRFX_RAM_BUFFER_SIZE
 	int "Size of RAM buffers for SPIM peripherals"
 	default 0
diff --git a/soc/arm/nordic_nrf/CMakeLists.txt b/soc/arm/nordic_nrf/CMakeLists.txt
index 3d2d9485ce2..44888db0160 100644
--- a/soc/arm/nordic_nrf/CMakeLists.txt
+++ b/soc/arm/nordic_nrf/CMakeLists.txt
@@ -4,4 +4,5 @@ add_subdirectory(${SOC_SERIES})
 
 zephyr_sources(
   validate_base_addresses.c
+  validate_enabled_instances.c
   )
diff --git a/soc/arm/nordic_nrf/validate_enabled_instances.c b/soc/arm/nordic_nrf/validate_enabled_instances.c
new file mode 100644
index 00000000000..87dacca5244
--- /dev/null
+++ b/soc/arm/nordic_nrf/validate_enabled_instances.c
@@ -0,0 +1,48 @@
+/*
+ * Copyright (c) 2020 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <kernel.h>
+
+#define I2C_ENABLED(idx)  (IS_ENABLED(CONFIG_I2C) && \
+			   DT_HAS_NODE(DT_NODELABEL(i2c##idx)))
+
+#define SPI_ENABLED(idx)  (IS_ENABLED(CONFIG_SPI) && \
+			   DT_HAS_NODE(DT_NODELABEL(spi##idx)))
+
+#define UART_ENABLED(idx) (IS_ENABLED(CONFIG_SERIAL) && \
+			   (IS_ENABLED(CONFIG_SOC_SERIES_NRF53X) || \
+			    IS_ENABLED(CONFIG_SOC_SERIES_NRF91X)) && \
+			   DT_HAS_NODE(DT_NODELABEL(uart##idx)))
+
+/*
+ * In most Nordic SoCs, SPI and TWI peripherals with the same instance number
+ * share certain resources and therefore cannot be used at the same time (in
+ * nRF53 and nRF91 Series this limitation concerns UART peripherals as well).
+ * In nRF52810 though, there are only single instances of these peripherals
+ * and they are arranged in a different way, so this limitation does not apply.
+ *
+ * The build assertions below check if conflicting peripheral instances are not
+ * enabled simultaneously.
+ */
+
+#define CHECK(idx) \
+	!(I2C_ENABLED(idx) && SPI_ENABLED(idx)) && \
+	!(I2C_ENABLED(idx) && UART_ENABLED(idx)) && \
+	!(SPI_ENABLED(idx) && UART_ENABLED(idx))
+
+#define MSG(idx) \
+	"Only one of the following peripherals can be enabled: " \
+	"SPI"#idx", SPIM"#idx", SPIS"#idx", TWI"#idx", TWIM"#idx", TWIS"#idx \
+	IF_ENABLED(CONFIG_SOC_SERIES_NRF53X, (", UARTE"#idx)) \
+	IF_ENABLED(CONFIG_SOC_SERIES_NRF91X, (", UARTE"#idx)) \
+	". Check nodes with status \"okay\" in zephyr.dts."
+
+#if !IS_ENABLED(CONFIG_SOC_NRF52810)
+BUILD_ASSERT(CHECK(0), MSG(0));
+#endif
+BUILD_ASSERT(CHECK(1), MSG(1));
+BUILD_ASSERT(CHECK(2), MSG(2));
+BUILD_ASSERT(CHECK(3), MSG(3));